In many cities, sectorization projects of the drinking water distribution network have been implemented. This study provides a methodology to evaluate the efficiency of the sectors of a water distribution network by applying a data envelopment analysis weighted Russell directional distance (DEA-WRDD) model. This non-radial DEA model gives the overall efficiency of each unit of analysis, as well as each input, output, and undesirable output considered in the evaluation. The variables used in the analysis provide a multidisciplinary view: economic factors (covering costs), water quality parameters, and technical aspects. The empirical analysis was performed for the sectors of the water distribution network of the city of Valencia (Spain) for the year 2016. In this particular case, the results showed that approximately half of the sectors were efficient. The efficiency values of each variable indicate that the main challenges (faced by the water distribution company) were the optimization of maintenance costs and the reduction of leaks, both of which have an impact on the quality of the distributed water. So, the purpose of this article is to highlight the usefulness of efficiency analysis to help the decision making of managers of sectorized water distribution networks so that they can optimize the management.