Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

Hsiao, Hua Tsen; Lee, Jun Jun; Chen, Hsiu‐Hui; Wu, Ming; Huang, Chi Wei; Chang, Ya Ting; Lien, Chia Yi; Wang, Jing Jy; Chang, Hsin Hsin; Chang, Chiung Chih

doi:10.1016/j.clnu.2018.09.017

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…The demographic data included gender, years of education, ApoE4 status, body mass index (BMI) [49], marital status, self-care ability, comorbidity and major caregiver status (spouse or others). For education, we considered it as a non-modifiable factor as our patients with AD may not obtain further educational years at the time of survey.…”

Section: Demographic Datamentioning

confidence: 99%

“…The interaction between diagnostic groups (all patients, RCD, stable group) and disease duration (months) was modeled. The interactions in BMI groups (overweight-normal or underweight-normal) and disease duration (months) were performed to assess the slope changes compared with normal BMI group [49]. For the effects of blood chemistry profiles, we performed correlation analysis with HbA1c, total cholesterol, HDL, LDL, B12 and folate as independent variables.…”

Section: Mri Acquisition Salient Regions Of Interest and Composite Co...mentioning

confidence: 99%

“…Based on our study results, underweight BMI was related to faster cortical atrophy in AD. Previously, Hsiao et al [49] reported the nutrition status and adequacy of BMI ranges in patients with AD. Considering the balance of comorbidities and nutritional status, a BMI of 22-23 kg/m 2 was suggested in AD.…”

Section: Dp-related Factors and Cortical Atrophymentioning

confidence: 99%

“…Age, gender, educational level, other profiles and living status were not related to RCD in our analysis. In a literature review, the presence of comorbidities [68], physical dependence [68], nutritional status [49,[69][70][71], nutritional knowledge [72] and social engagement [68] were all reported to affect cognitive decline in the elderly.…”

Section: Factors Associated With Rapid Declinementioning

confidence: 99%

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Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry

et al. 2022

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Dietary pattern (DP) results in nutrition adequacy and may influence cognitive decline and cortical atrophy in Alzheimer’s disease (AD). The study explored DP in 248 patients with AD. Two neurobehavioral assessments (intervals 13.4 months) and two cortical thickness measurements derived from magnetic resonance images (intervals 26.5 months) were collected as outcome measures. Reduced rank regression was used to assess the groups of DPs and a linear mixed-effect model to explore the cortical neurodegenerative patterns. At screening, underweight body mass index (BMI) was related to significant higher lipid profile, impaired cognitive function, smaller cortical thickness, lower protein DP factor loading scores and the non-spouse caregiver status. Higher mini-mental state examination (MMSE) scores were related to the DP of coffee/tea, compared to the lipid/sugar or protein DP group. The underweighted-BMI group had faster cortical thickness atrophy in the pregenual and lateral temporal cortex, while the correlations between cortical thickness degeneration and high HbA1C or low B12 and folate levels were localized in the medial and lateral prefrontal cortex. The predictive model suggested that factors related to MMSE score were related to the caregiver status. In conclusion, normal or overweight BMI, coffee/tea DP group and living with a spouse were considered as protective factors for better cognitive outcomes in patients with AD. The influence of glucose, B12 and folate on the cortical degeneration was spatially distinct from the pattern of AD degeneration.

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Section: Demographic Datamentioning

confidence: 99%

Section: Mri Acquisition Salient Regions Of Interest and Composite Co...mentioning

confidence: 99%

Section: Dp-related Factors and Cortical Atrophymentioning

confidence: 99%

Section: Factors Associated With Rapid Declinementioning

confidence: 99%

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Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry

et al. 2022

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“…After enrollment, the demographic data of each patient were recorded, including symptom onset age (year-old), years of education, gender, and body mass index (BMI) [ 17 ]. The major blood chemistry profiles included homocysteine, vitamin B12, and folate levels.…”

Section: Methodsmentioning

confidence: 99%

Diet Pattern Analysis in Alzheimer’s Disease Implicates Gender Differences in Folate–B12–Homocysteine Axis on Cognitive Outcomes

Ting,

Ma,

Chang

et al. 2024

Nutrients

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Background & Aims: Low plasma B12 and folate levels or hyperhomocysteinemia are related to cognitive impairment. This study explores the relationships among diet pattern, blood folate–B12–homocysteine levels, and cognition measurement in Alzheimer’s disease (AD) while exploring whether a gender effect may exist. Methods: This cross-sectional study enrolled 592 AD patients (246 males, 346 females) and the demographic data, blood biochemical profiles, Mini-Mental State Examination (MMSE), and a Food Frequency Questionnaire (FFQ) for quantitative assessment of dietary frequency were collected. Structural Equation Modeling (SEM) was employed to explore the associations among dietary patterns, blood profiles, and cognition. A least absolute shrinkage and selection operator regression model, stratified by gender, was constructed to analyze the weighting of possible confounders. Results: Higher MMSE scores were related to higher frequencies of coffee/tea and higher educational levels, body mass index, and younger age. The SEM model revealed a direct influence of dietary frequencies (skimmed milk, thin pork, coffee/tea) and blood profiles (homocysteine, B12, and folate) on cognitive outcomes. At the same time, the influence of dietary pattern on cognition was not mediated by folate–B12–homocysteine levels. In males, a direct influence on the MMSE is attributed to B12, while in females, homocysteine is considered a more critical factor. Conclusions: Dietary patterns and blood profiles are both associated with cognitive domains in AD, and there are gender differences in the associations of dietary patterns and the levels of B12 and homocysteine. To enhance the quality of dietary care and nutritional status for individuals with dementia, our study results still require future validations with multi-center and longitudinal studies.

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Dietary Recommendations for Managing Dementia

Mashhadi,

Roudi,

Aminalroaya

et al. 2024

Nutritional Neurosciences

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Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

Cited by 10 publications

References 32 publications

Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry

Cognitive Decline Related to Diet Pattern and Nutritional Adequacy in Alzheimer’s Disease Using Surface-Based Morphometry

Diet Pattern Analysis in Alzheimer’s Disease Implicates Gender Differences in Folate–B12–Homocysteine Axis on Cognitive Outcomes

Dietary Recommendations for Managing Dementia

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