We prove a variant of Serre's weight conjecture for ρ : Gal(F /F ) −→ GSp 4 (Fp) for any totally real field F and any rational prime p > 2 by using automorphic lifting techniques developed by Barnet-Lamb, Gee, Geraghty, and Taylor. The formulation of our Serre conjecture is done by following Toby Gee's philosophy. Applying these results to the case when F = Q with a detailed study of potentially diagonalizable, crystalline lifts with some prescribed properties, we also define classical (naive) Serre's weights. This weight would be the minimal weight among possible classical weights in some sense which occur in candidates of holomorphic Siegel Hecke eigen cusp forms of degree 2 with levels prime to p. The main task is to construct a potentially diagonalizable automorphic lift for ρ by assuming only the adequacy condition. The main theorems in this paper also extend many results obtained by Gee and Geraghty [6] for potentially ordinary lifts and Gee and Geraghty for companion forms [36].