Adequate vitamin D level associated with reduced risk of sporadic colorectal cancer

Abstract

PurposeThe effect of vitamin D level pertinent to colorectal cancer incidence, progression, or mortality risk is complicated, and study findings are mixed. Therefore, we evaluated whether serum vitamin D [25-hydroxyvitamin D, 25(OH)D] is associated with the incidence of sporadic colorectal cancer (CRC).MethodsThis study is a retrospective analysis of the relationship between serum 25(OH)D level and the risk of CRC. Age, sex, body mass index, history of polyp, disease conditions (i.e., diabetes), medications, and other eight vitamins were used as confounding factors. A total of 389 participants were enrolled in this study, including comprising 83 CRC patients without a family history and 306 healthy controls, between January 2020 and March 2021 at the Department of Colorectal Surgery and Endoscope Center at the Xinhua Hospital, Shanghai Jiao Tong University School of Medicine. Adjusted smoothing spline plots, subgroup analysis, and multivariate logistic regression analysis were conducted to estimate the relative risk between serum 25(OH)D and sporadic CRC risk.ResultsAfter fully adjusting the confounding factors, it was found that circulating 25(OH)D played a protective role in patients with CRC (OR = 0.76 [0.63, 0.92], p = 0.004) and that an adequate vitamin D level was significantly associated with a reduced CRC risk compared to vitamin D deficiency or sufficiency (OR = 0.31 [0.11, 0.9], p = 0.03). According to this study, statins did not affect the potential protective effects of vitamin D (OR = 1.02 [0.97, 1.08], p = 0.44) and may account for the inverse association between serum 25(OH)D and colorectal cancer.ConclusionAn adequate level of serum 25(OH)D was associated with a reduced CRC risk, especially for the elderly. The finding on the absence of protective effect of vitamin D in the statin use subgroup, suggests it may be one of the substantial contributing confounders, and warrants further investigation.

Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

“…VDR signaling pathway has a crucial role in several physiological activities, such as bone development, anti-inflammatory response, and anti-tumor activities ( Shang and Sun, 2017 ). Notably, a decrease in both the serum vitamin D levels and the expression of VDR in the colon has been observed in patients with colitis or colorectal cancer ( Chen and Jin, 2022 ; Ma et al, 2023 ). In a study using a mouse model of colitis-associated cancer, treatment with asperuloside was found to significantly enhance the expression of VDR in the colon, leading to marked reductions in colitis symptoms and a decrease in both the quantity and size of tumors ( Lu et al, 2022 ).…”

Organic Synthesis of New Secosteroids from Fucosterol, Its Intestinal Absorption by Caco-2 Cells, and Simulation of the Biological Activities of Vitamin D

“…As depicted in Figure 2, the final high-performance liquid chromatography (HPLC) analysis isolated two pure compounds-compounds 3 and 4. We used various nuclear magnetic resonance (NMR) techniques to examine their structures, including 1 H-NMR, 13 C-NMR, COSY-NMR, HSQC-NMR, HMBC-NMR, and NOESY-NMR. The peak (b) at 75.4 min (Figure 2B) was identified as the desired compound 3 (Figure 3).…”

“…[α] 2H, H-4a, H-4b), 4.60 (m, 1H, H-3), 5.18 (q, 1H, J = 6.7 Hz, H-24 1 ), 5.37 (d, 1H, J = 4.9 Hz, H-6); 13 N-Bromosuccinimide (NBS) (176 mg, 0.989 mmol) was added, and the reaction mixture was stirred under reflux conditions (100 • C) for 1.5 h. The reaction temperature was lowered to room temperature, and 15 mL of water was added. The mixture was stirred at room temperature for an additional 1 h. The reactants were extracted with normal hexane and washed with water, and the solvent was removed under vacuum.…”

“…Vitamin D plays a multi-faceted role in human health. Specifically, its blood levels are associated with a range of health conditions and risks, including maternal and child health [3,4], reproductive functions [5][6][7], physical performance [8], renal function [9], and sleep quality [10], as well as diseases like cancer [11][12][13][14], lung disease [15][16][17][18][19], vascular disease [20][21][22], metabolic syndrome [23,24], dementia [25,26], psychiatric disorders [27][28][29][30], viral diseases [31][32][33][34][35] including COVID-19, and intractable diseases like myofibromyalgia [36]. Furthermore, adequate vitamin D levels can reduce chronic inflammation, a known trigger for various serious diseases [37,38].…”

Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL

“…Vitamin D has been discovered to exert anti-tumor effects and be a predictor of prognosis in cancers (Santos and Hussain 2019 ; Urashima et al 2019 ). Sufficient vitamin D levels were related with a decreased risk of sporadic colorectal cancer (Ma et al 2023 ). Low vitamin D levels had correlation with poorer prognosis in primary melanomas (Timerman et al 2017 ).…”