“…Among these strategies, nutraceutical supplements, which are compounds of vitamins, minerals, and essential amino- and fatty acids, as well as plant extract isolates [ 21 , 282 ], may have further advantages ( Figure 1 ): they (i) are widely available and commonly used; (ii) they affect a highly evolutionarily conserved nutrient-sensing pathway ( this pathway regulates several key homeostatic processes, including autophagy, mRNA translation, and metabolism, each of which affects the hallmarks of aging [ 13 , 34 ] and, consequently, the lifespan [ 285 , 286 ] ) linked to aging [ 287 , 288 ]; (iii) could prevent or slow the progression of a wide variety of illnesses [ 90 , 283 , 284 ], including neurodegeneration [ 289 , 290 , 291 ]; (iv) can affect the central circadian clock in the brain via sirtuins [ 134 , 292 ], which are linked to the regulation of aging [ 9 , 177 , 293 , 294 ]; and (v) do not require as much effort to comply with recommendations, for example, committing to regular physical exercise [ 295 , 296 , 297 ] or maintaining a rigorous diet [ 298 , 299 , 300 , 301 ]. Moreover, considering that many nutraceutical compounds are mimetics of calorie restriction [ 302 ] or physical exercise [ 303 ], manipulating the dosage of such compounds could achieve stronger and faster results.…”