Adherence and treatment satisfaction in liver transplant recipients

Abstract

Background/Aims:Liver transplantation (LT) is a life-saving intervention for patients with liver failure. LT recipients' adherence to their therapeutic regimen is an essential element for graft survival. According to WHO, the impact of medication non-adherence in solid organ transplantation has shown to cost $15–100 million annually. The aim of the present study was to identify the factors that best predict medication adherence and to explore the relationship between treatment satisfaction and medication adherence in liver transplant recipients.Patients and Methods:Adult liver transplant patients at King Abdulaziz Medical City were included in the study. Patients completed the 8-item Morisky Medication Adherence Scale (MMAS-8) and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4) in addition to several socio-demographic and transplant-related data.Results:A total of 154 patients were included in the study and of these 59.7% were adherent. Older age was a significant predictor of adherence (P < 0.05). The mean treatment satisfaction score was 91.9 ± 12.7 in Effectiveness, 80.0 ± 25.9 in Side Effects, 83.5 ± 15.7 in Convenience, and 94.6 ± 8.6 in Global Satisfaction. Further analysis indicated that patients in the adherent group had reported significantly higher satisfaction scores than those in the non-adherent group (P < 0.05) in all treatment satisfaction domains: Effectiveness (94.4 ± 10.4 vs. 88.6 ± 14.8), Side Effects (83.9 ± 22.0 vs. 74.2 ± 30.1), Convenience (87.0 ± 13.9 vs. 77.2 ± 16.1), and Global Satisfaction (96.9 ± 6.6 vs. 91.2 ± 8.6).Conclusion:Older patients and those who were more satisfied with their treatment tend to have better adherence to the prescribed medications. Therefore, increasing patients' satisfaction with their treatment should be an integral element of future care plans designed to improve treatment outcomes in liver transplant recipients.

Factors predicting self-reported medication low adherence in a large sample of adults in the US general population: a cross-sectional study

“…This has been validated against other adherence sources such as pharmacy dispensing database fill data13 and is accredited/endorsed by the American Medical Association and American Pharmaceutical Association. It has been widely used in adherence research for multiple disease states and medications across numerous countries 14–17. In this study, the MMAS-8 was used to assess for self-reported low adherence in general and was not grounded in any specific conditions or medications.…”

“…It has been widely used in adherence research for multiple disease states and medications across numerous countries. [14][15][16][17] In this study, the MMAS-8 was used to assess for self-reported low adherence in general and was not grounded in any specific conditions or medications. MMAS-8 scores can range from 0 to 8 with low adherence defined as a score <6, medium adherence as scores of 6 or 7 and high adherence with a score of 8.…”

Adesão Ao Tratamento No Transplante De Fígado: Revisão Integrativa

“…Outra categoria foi a relacionada à "adoção de um plano terapêutico individualpresença de não adesão relacionada ao não atendimento das necessidades específicas do paciente", composta por três artigos (21,(26)(27) .…”

“…3. Adherence and treatment satisfaction in liver transplant recipients (21) 2016 Albekairy AM, Alkatheri AM Jarab A, Khalidi N, Althiab K, Alshaya A, et al…”

“…2 Implementar uma abordagem educacional farmacêutica para a melhoria da adesão à terapia de drogas imunossupressoras no hospital Siriraj (20) . 3 Identificar os fatores que melhores predizem a adesão à medicação e explorar a relação entre a satisfação com o tratamento e a adesão à medicação em paciente submetidos ao transplante hepático (21) . 4 Avaliar a segurança, eficácia e adesão à imunossupressão através da conversão da dose de Tacrolimus de duas vezes ao dia para uma vez ao dia, em adultos transplantados hepáticos estáveis (por doador vivo) (22) .…”