Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions

Maldonado-Gómez, María X.; Lee, Hyeyoung; Lü, Mei; Hutkins, Robert W.

doi:10.1016/j.idairyj.2014.08.014

Cited by 22 publications

(11 citation statements)

References 77 publications

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“…BMOs and bovine milk glycoconjugates can inhibit adhesion of pathogens to intestinal cells and tissues (Douellou et al 2017, Maldonado-Gomez et al 2015). Associations between sialylated BMOs and microbiota-dependent growth promotion have been described (Charbonneau et al 2016b).…”

Section: Structure-function Associations Of Milk Glycansmentioning

confidence: 99%

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Kirmiz

Robinson

Shah

et al. 2018

Annu. Rev. Food Sci. Technol.

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108

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Human milk is a unique and complex fluid that provides infant nutrition and delivers an array of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found as free oligosaccharides or as glycoconjugates. Milk glycans are increasingly linked to beneficial outcomes in neonates through protection from pathogens and modulation of the immune system. Indeed, these glycans influence the development of the infant and the infant-gut microbiota. Bifidobacterium species commonly are enriched in breastfed infants and are among a limited group of bacteria that readily consume human milk oligosaccharides (HMOs) and milk glycoconjugates. Given the importance of bifidobacteria in infant health, numerous studies have examined the molecular mechanisms they employ to consume HMOs and milk glycans, thus providing insight into this unique enrichment and shedding light on a range of translational opportunities to benefit at-risk infants.

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Section: Structure-function Associations Of Milk Glycansmentioning

confidence: 99%

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Kirmiz

Robinson

Shah

et al. 2018

Annu. Rev. Food Sci. Technol.

Self Cite

108

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“…Recent in vitro studies have demonstrated that BMO also possess antibacterial properties as observed for HMO. BMO from colostrum permeate proved to be effective in protecting HEp-2 cells from enteropathogenic E. coli , Cronobacter sakazakii , and Salmonella enterica serovar typhimurium [ 149 ]. It has also been demonstrated that BMO can inhibit the pili-mediated adhesion of Neisseria meningitidis in vitro [ 150 ].…”

Section: Impact Of Milk Oligosaccharides On Human Healthmentioning

confidence: 99%

Milk Proteins, Peptides, and Oligosaccharides: Effects against the 21st Century Disorders

Hsieh

Hernández-Ledesma

Fernández-Tomé

et al. 2015

BioMed Research International

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Milk is the most complete food for mammals, as it supplies all the energy and nutrients needed for the proper growth and development of the neonate. Milk is a source of many bioactive components, which not only help meeting the nutritional requirements of the consumers, but also play a relevant role in preventing various disorders. Milk-derived proteins and peptides have the potential to act as coadjuvants in conventional therapies, addressing cardiovascular diseases, metabolic disorders, intestinal health, and chemopreventive properties. In addition to being a source of proteins and peptides, milk contains complex oligosaccharides that possess important functions related to the newborn's development and health. Some of the health benefits attributed to milk oligosaccharides include prebiotic probifidogenic effects, antiadherence of pathogenic bacteria, and immunomodulation. This review focuses on recent findings demonstrating the biological activities of milk peptides, proteins, and oligosaccharides towards the prevention of diseases of the 21st century. Processing challenges hindering large-scale production and commercialization of those bioactive compounds have been also addressed.

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“…Thus, the bacterial composition of colostrum can be highly important for microbial colonization of the gut. In addition, colostrum contains certain oligosaccharides that are of importance of gut health, for example, by inhibiting the adherence of pathogens to the intestinal epithelial cells (Maldonado-Gomez et al 2015 ) or by serving as growth substances for the establishing bacterial community (Yu et al 2013 ; E Hernandez-Castellano et al 2014 ; Fischer et al 2018 ). Besides the effects of colostrum, exposure to antimicrobials early in life can also influence establishment of the gut microbiota (Oultram et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the developing gut microbiota in young dairy calves—impact of colostrum microbiota and gut disturbances

Hang

Wredle

Dicksved

2020

Trop Anim Health Prod

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The aim of this study was to characterize the colostrum and fecal microbiota in calves and to investigate whether fecal microbiota composition was related to colostrum microbiota or factors associated with calf health. Colostrum samples were collected in buckets after hand milking of 76 calving cows from 38 smallholder dairy farms. Fecal samples were taken directly from the rectum of 76 calves at birth and at 14 days age. The bacterial community structure in colostrum and feces was analyzed by terminal restriction fragment length polymorphism for all samples, and the microbial composition was determined by 16S rRNA gene amplicon sequencing for a subset of the samples (8 colostrum, 40 fecal samples). There was a significant difference in fecal microbiota composition between day 0 and day 14 samples, but no associations between the microbiota and average daily gain, birth weight, or transfer of passive immunity. At 14 days of age, Faecalibacterium and Butyricicoccus were prevalent in higher relative abundances in the gut of healthy calves compared to calves with diarrhea that had been treated with antimicrobials. Colostrum showed great variation in composition of microbiota but no association to fecal microbiota. This study provides the first insights into the composition of colostrum and fecal microbiota of young dairy calves in southern Vietnam and can form the basis for future more detailed studies.

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Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions

Cited by 22 publications

References 77 publications

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Milk Glycans and Their Interaction with the Infant-Gut Microbiota

Milk Proteins, Peptides, and Oligosaccharides: Effects against the 21st Century Disorders

Analysis of the developing gut microbiota in young dairy calves—impact of colostrum microbiota and gut disturbances

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