“…This study will be the first trial dedicated to ACS patients, testing whether a DOAC-based dual approach is superior to a VKA-based triple approach in high-risk ACS patients with AF in terms of bleeding. In the context of combined APT and anticoagulant therapy however, Fiocca et al [22] raise the important issue of adherence to therapy. The Italian group assessed cessation patterns and causes of ticagrelor discontinuation in the AD-HOC (ADHerence of ticagrelOr in real-world patients with aCute coronary syndrome) cohort, and identified OAC as an independent predictor of premature ticagrelor cessation.…”