Adherence properties of : Impact on pathogenesis and adaptation to the host

Odenbreit, Stefan

doi:10.1016/j.ijmm.2005.06.003

Cited by 83 publications

(69 citation statements)

References 62 publications

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“…During this process, some adhesive proteins from the H. pylori membrane are affected and form a strong attachment to gastric epithelial cells (8). Outer membrane proteins, including blood group antigen-binding adhesion (BabA), adherence-associated lipoprotein A (AlpA), and adherence-associated lipoprotein B (AlpB), reportedly contribute to this process (9). Therefore, H. pylori could be eradicated by suppressing its motility or adhesion.…”

mentioning

confidence: 99%

In VitroandIn VivoAntibacterial Activities of Patchouli Alcohol, a Naturally Occurring Tricyclic Sesquiterpene, against Helicobacter pylori Infection

Lian

Chen

et al. 2017

Antimicrob Agents Chemother

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This study further evaluated the in vitro and in vivo anti-Helicobacter pylori activities and potential underlying mechanism of patchouli alcohol (PA), a tricyclic sesquiterpene. In the in vitro assay, the capacities of PA to inhibit and kill H. pylori were tested on three standard strains at different pH values and on 12 clinical isolates. The effects of PA on H. pylori adhesion (and its alpA, alpB, and babA genes), motility (and its flaA and flaB genes), ultrastructure, and flagellation were investigated. Moreover, the H. pylori resistance to and postantibiotic effect (PAE) of PA were determined. Furthermore, the in vivo effects of PA on H. pylori eradication and gastritis were examined. Results showed that MICs of PA against three standard strains (pH 5.3 to 9) and 12 clinical isolates were 25 to 75 and 12.5 to 50 g/ml, respectively. The killing kinetics of PA were time and concentration dependent, and its minimal bactericidal concentrations (MBCs) were 25 to 75 g/ml. In addition, H. pylori adhesion, motility, ultrastructure, and flagellation were significantly suppressed. PA also remarkably inhibited the expression of adhesion genes (alpA and alpB) and motility genes (flaA and flaB). Furthermore, PA treatment caused a longer PAE and less bacterial resistance than clarithromycin and metronidazole. The in vivo study showed that PA can effectively eradicate H. pylori, inhibit gastritis, and suppress the expression of inflammatory mediators (COX-2, interleukin 1␤, tumor necrosis factor alpha, and inducible nitric oxide synthase [iNOS]). In conclusion, PA can efficiently kill H. pylori, interfere with its infection process, and attenuate gastritis with less bacterial resistance, making it a potential candidate for new drug development.

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mentioning

confidence: 99%

In VitroandIn VivoAntibacterial Activities of Patchouli Alcohol, a Naturally Occurring Tricyclic Sesquiterpene, against Helicobacter pylori Infection

Lian

Chen

et al. 2017

Antimicrob Agents Chemother

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“…Attachment of Helicobacter pylori to host gastric epithelial cells is believed to play an important role in bacterial colonization and in cellular and humoral immune responses to infection (1,2). For example, direct contact between the bacteria and the epithelium is required for the release of inflammatory mediators, such as IL-8, 2 which results in the mucosal accumulation of neutrophils (3).…”

mentioning

confidence: 99%

“…For example, direct contact between the bacteria and the epithelium is required for the release of inflammatory mediators, such as IL-8, 2 which results in the mucosal accumulation of neutrophils (3).…”

mentioning

confidence: 99%

Functional and Intracellular Signaling Differences Associated with the Helicobacter pylori AlpAB Adhesin from Western and East Asian Strains

Lü

Beswick³

et al. 2007

Journal of Biological Chemistry

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“…H. pylori that have survived the acid in the stomach are then able to negotiate the thick gastric mucous layer, courtesy of their spiral shape and multiple polar flagella (108,150). After traversing the mucous layer and reaching the gastric epithelium, H. pylori is believed to avoid being flushed away during the continual replenishment of the gastric mucosa by using a range of adhesins to tightly attach to the cells of the gastric epithelium (109). This allows H. pylori to escape the acidic conditions in the lumen of the stomach and gain access to gastric epithelial cells, which may act as a source of essential nutrients following vacuolating cytotoxin A (VacA)-dependent cell permeabilization (139).…”

Section: Colonization Of the Gastric Nichementioning

confidence: 99%

A role for altered phagosome maturation in the long-term persistence ofHelicobacter pyloriinfection

Borlace

Keep

Prodoehl

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

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The vigorous host immune response that is mounted against Helicobacter pylori is unable to eliminate this pathogenic bacterium from its niche in the human gastric mucosa. This results in chronic inflammation, which can develop into gastric or duodenal ulcers in 10% of infected individuals and gastric cancer in 1% of infections. The determinants for these more severe pathologies include host (e.g., high IL-1β expression polymorphisms), bacterial [e.g., cytotoxicity-associated gene ( cag) pathogenicity island], and environmental (e.g., dietary nitrites) factors. However, it is the failure of host immune effector cells to eliminate H. pylori that underlies its persistence and the subsequent H. pylori-associated disease. Here we discuss the mechanisms used by H. pylori to survive the host immune response and, in particular, the role played by altered phagosome maturation.

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Adherence properties of : Impact on pathogenesis and adaptation to the host

Cited by 83 publications

References 62 publications

In VitroandIn VivoAntibacterial Activities of Patchouli Alcohol, a Naturally Occurring Tricyclic Sesquiterpene, against Helicobacter pylori Infection

In VitroandIn VivoAntibacterial Activities of Patchouli Alcohol, a Naturally Occurring Tricyclic Sesquiterpene, against Helicobacter pylori Infection

Functional and Intracellular Signaling Differences Associated with the Helicobacter pylori AlpAB Adhesin from Western and East Asian Strains

A role for altered phagosome maturation in the long-term persistence ofHelicobacter pyloriinfection

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