Adherence, Side Effects and Efficacy of Stavudine plus Lamivudine plus Nelfinavir in Treatment-experienced HIV-infected Patients

Roca, Bernardino; Gómez, Cayetano J.; Arnedo, Alberto

doi:10.1053/jinf.2000.0678

Cited by 43 publications

(23 citation statements)

References 25 publications

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“…For the fortunate 20% of those in need worldwide for whom it is available [2], HAART has dramatically reduced viral load; improved immunologic status, physical health, and quality of life; and contributed to substantial declines in HIV-related morbidity and mortality (eg, [3][4][5][6][7][8]). …”

Section: Introductionmentioning

confidence: 99%

“…HAART is less tolerant of nonadherence than most other medications, and even brief or intermittent nonadherence may cause serious negative outcomes. In addition, HAART's multiple acute (eg, nausea, vomiting) and chronic (eg, anemia, peripheral neuropathy) side effects challenge patients, and some HAART side effects may markedly impair physical health and quality of life [6,32,33].…”

Section: Introductionmentioning

confidence: 99%

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The Information-Motivation-Behavioral Skills model of antiretroviral adherence and its applications

Fisher

Amico²,

Fisher³

et al. 2008

Curr HIV/AIDS Rep

164

151

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Suboptimal adherence to highly active antiretroviral therapy (HAART) may have serious consequences for HIV patients, and for public health overall. The Information-Motivation-Behavioral Skills (IMB) model of HAART adherence can be used to understand the dynamics of HAART adherence and to intervene with patients to promote more optimal levels of adherence. This article reviews the core hypotheses of the IMB model of HAART adherence and describes available correlational and experimental evaluations of the model, outcomes of adherence intervention trials that applied the model, and IMB model-based interventions that are currently under evaluation. It then explores one potential promising application of the model that uses a protocol originally developed and demonstrated as a structured patient-centered, provider-delivered risk reduction intervention to deliver information, motivation, and behavioral skills-based adherence-promotion strategies. This protocol could be incorporated into clinical practice as a valuable tool in working with patients individually.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Information-Motivation-Behavioral Skills model of antiretroviral adherence and its applications

Fisher

Amico²,

Fisher³

et al. 2008

Curr HIV/AIDS Rep

164

151

View full text Add to dashboard Cite

show abstract

“…[3][4][5] Studies on adherence to antiretroviral medications among individuals with HIV disease have focused on different HIV populations groups (e.g., men who have sex with men, women, injecting drug users, adolescents) 6-9 across various settings (clinics, hospitals, clinical trial groups). 7,10,11 Among HIV-infected children and adolescents, adherence has ranged from 50%-61%. 9,12,13 For postpartum HIV-infected patients attending a major urban hospital in New York, only 28% were adherent during the previous 2 months.…”

Section: Introductionmentioning

confidence: 99%

Attitudes Toward HIV Protease Inhibitors and Medication Adherence in an Inner City HIV Population

Demmer

2003

AIDS Patient Care and STDs

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The objective of this pilot study was to examine attitudes toward protease inhibitors (PIs) among HIV-infected individuals and to assess the relationship between PI attitudes and adherence to PIs. Respondents were recruited from four AIDS service organizations in New York City; the total sample consisted of 97 HIV-infected individuals who were taking a PI. The sample consisted largely of African Americans and Latinos from inner city areas, and most had a low level of education. Adherence was suboptimal, with more than 50% of respondents failing to take their PI medications exactly as prescribed within the previous month. Individuals who had recently used illegal drugs within the past 6 months were more likely to be nonadherent to PIs. Those who were not adherent to PI medications reported greater concern about the side effects of PIs and were more likely to believe that it was acceptable to skip doses of PIs.

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“…Some studies and reviews reported that side effects may be an important cause of noncompliance (Davies & Lilleyman, 1995;Partridge et al, 2002;Roca, Gomez, & Arnedo, 2000). However, how frequent and severe chemotherapy-related side-effects in childhood ALL are and how it influences protocol compliance and daily activities is unknown.…”

mentioning

confidence: 99%

Chemotherapy-Related Side Effects in Childhood Acute Lymphoblastic Leukemia in Indonesia: Parental Perceptions

Sitaresmi

Mostert

Purwanto

et al. 2009

J Pediatr Oncol Nurs

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Noncompliance with prescribed medication has been associated with increased chance of relapse and poor outcome. Side effects may be an important cause of noncompliance. Fifty-one parents of children with acute lymphoblastic leukemia in a tertiary care hospital in Indonesia were interviewed about their perception of side effects and their impact on treatment noncompliance and daily activities. A symptom checklist assessing 13 common symptoms was used to examine side effects. During chemotherapy, childhood acute lymphoblastic leukemia patients suffered from psychological as well as physical side effects. The most frequent side effect reported by parents was behavior alteration (92%). Second and third in frequency were increased appetite and infections, reported by 88% and 83% of parents, respectively. The most severe side effects were leg weakness, increased appetite, and behavior alteration. The overall frequency of side effects was weakly correlated to noncompliance. Reducing the impact of side effects may increase compliance with the treatment.

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Adherence, Side Effects and Efficacy of Stavudine plus Lamivudine plus Nelfinavir in Treatment-experienced HIV-infected Patients

Cited by 43 publications

References 25 publications

The Information-Motivation-Behavioral Skills model of antiretroviral adherence and its applications

The Information-Motivation-Behavioral Skills model of antiretroviral adherence and its applications

Attitudes Toward HIV Protease Inhibitors and Medication Adherence in an Inner City HIV Population

Chemotherapy-Related Side Effects in Childhood Acute Lymphoblastic Leukemia in Indonesia: Parental Perceptions

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