Adherence to a healthy plant diet may reduce inflammatory factors in obese and overweight women-a cross-sectional study

Bolori, Parvin; Setaysh, Leila; Rasaei, Niloufar; Jarrahi, Farshad; Yekaninejad, Mirsaeed; Mirzaei, Khadijeh

doi:10.1016/j.dsx.2019.07.019

Cited by 39 publications

(41 citation statements)

References 18 publications

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“…Emerging evidence has shown that many nutrients, including dairy products 233 , exert effects through modulation of factors regulating inflammation 234 and/or telomere attrition 235 . Below we discuss the effects of some nutrients with anti-inflammatory activities, for example polyphenols (involved in protection against ultraviolet radiation and pathogens in plants) present in spices, fruits, in red wine, tea, coffee and chocolate.…”

Section: Nutrients That Target the Nrf2 Pathwaymentioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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stress and premature ageing are common features of the uremic phenotype.• The foodome -defined as the pool of all compounds present in a food sample and/or in a biological system interacting with the investigated food -can be implicated in the modulation of CKD complications.• Imbalance in the relative diversity of the gut microbiota has been studied extensively in CKD due its links with inflammation and cardiovascular risk. In this direction, researchers are evaluating the effects of pre-, pro-and synbiotics and many others food components like polyphenol-rich foods, sugar, proteins, etc. on both the modulation of the diversity of the gut microbiota and reduction in the levels of uremic toxins .• The use of bioactive compounds, found in curcumin, broccoli sprouts, berries, propolis, etc. may be valid nutritional therapeutic agents to modulate the expression of pro-inflammatory transcription factors, such as Nrf2, NF-kB and the inflammasome.• Senotherapeutic dietary compounds may mitigate the effects of a dysregulated ageing process in CKD and associated complications. including disturbed mitochondrial metabolism.Onion and garlic -may decrease NLRP3 activation Spinach -rich in betaine Green leafy vegetables -rich in folate Cruciferous vegetables, -rich in sulforaphane -may decrease NLRP3 activation, Nrf2 activators Some vegetables, such as spinach, broccoli, potatoes, cucumbers, green leafy -rich in potassium.

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Section: Nutrients That Target the Nrf2 Pathwaymentioning

confidence: 99%

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

et al. 2020

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“…A substantial amount of evidence suggests that many foods, nutrients and non-nutrient components modulate inflammation and immune function, both acutely and chronically [14][15][16]. In particular, a reduction in inflammatory markers (hs-CRP and TGF-ß) has been observed in individuals adhering to a healthy plant-based diet [17,18]. More specifically, a role has been proposed for dietary nitrate, the main source of which is leafy green vegetables such as spinach and lettuce [19] .…”

Section: Introductionmentioning

confidence: 99%

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Menni

Louca

Berry

et al. 2021

BMC Med

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Background Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts. Results Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q < 0.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet. Conclusion A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella. Trial registration The ClinicalTrials.gov registration identifier is NCT03479866.

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“…However, those with the greatest adherence to hPDs had reduced mortality. Lastly, in a smaller, cross-sectional study consisting of 240 middle-aged women, hPD was significantly associated with reduced inflammatory biomarkers compared to uPD [152]. Thus, based on these data, consumption of a plant-based diet comprising unrefined, whole plant-foods can confer beneficial health effects…”

Section: Considerations For Health Beyond Weight Lossmentioning

confidence: 99%

Plant-Based Diets in the Reduction of Body Fat: Physiological Effects and Biochemical Insights

Najjar

Feresin

2019

Nutrients

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Obesity affects over one-third of Americans and increases the risk of cardiovascular disease and type II diabetes. Interventional trials have consistently demonstrated that consumption of plant-based diets reduces body fat in overweight and obese subjects, even when controlling for energy intake. Nonetheless, the mechanisms underlying this effect have not been well-defined. This review discusses six major dietary mechanisms that may lead to reduced body fat. These include (1) reduced caloric density, (2) improved gut microbiota symbiosis, (3) increased insulin sensitivity, (4) reduced trimethylamine-N-oxide (TMAO), (5) activation of peroxisome proliferator-activated receptors (PPARs), and (6) over-expression of mitochondrial uncoupling proteins. Collectively, these factors improve satiety and increase energy expenditure leading to reduced body weight.

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Adherence to a healthy plant diet may reduce inflammatory factors in obese and overweight women-a cross-sectional study

Cited by 39 publications

References 18 publications

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

Food as medicine: targeting the uraemic phenotype in chronic kidney disease

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Plant-Based Diets in the Reduction of Body Fat: Physiological Effects and Biochemical Insights

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