Adherence to antiepileptic drugs among children attending a tertiary health unit in a low resource setting

Nazziwa, Rose; Mwesige, Angelina Kakooza; Obua, Celestino; Ssenkusu, John M.; Mworozi, Edison

doi:10.11604/pamj.2014.17.44.3399

Cited by 27 publications

(37 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Ugandan study found that almost 80% of people reported being adherent to AED treatment, but only about a quarter were adherent when serum drug levels were checked [49]. Good adherence to AED is associated with better seizure control, improved job prospects, increased productivity, reduced road traffic accidents, and a better overall QOL [111].…”

Section: Discussionmentioning

confidence: 99%

“…Most of the programs (75%) target rural or suburban populations. Even where care was based in tertiary care centers, they also served rural and community outposts [45,49,59]. Some of the rural care programs recruited individuals for treatment following epidemiological surveys, community engagements or after recognizing particular needs.…”

Section: Characteristics Of the Publications Retrievedmentioning

confidence: 99%

See 1 more Smart Citation

Health service provision for people with epilepsy in sub-Saharan Africa: A situational review

Watila

Keezer

Angwafor

et al. 2017

Epilepsy & Behavior

View full text Add to dashboard Cite

We attempted to provide a 'snapshot' of epilepsy care services in SSA. The successes achieved in some of the centers are due to the use of existing primary health-care systems and employing non-physician health-care personnel. The true picture of epilepsy care coverage is not apparent due to the lack of data and proper health system structure in most parts of SSA. As more individuals begin to receive care, the long-term funding for epilepsy care in African countries will depend on the commitment of their respective governments.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Characteristics Of the Publications Retrievedmentioning

confidence: 99%

Health service provision for people with epilepsy in sub-Saharan Africa: A situational review

Watila

Keezer

Angwafor

et al. 2017

Epilepsy & Behavior

View full text Add to dashboard Cite

show abstract

“…10 Our findings are in fact similar to other adherence data based solely on self-report of the pediatric patient or parent. 11,12,32 …”

Section: Discussionmentioning

confidence: 99%

Interviewing and Urine Drug Toxicology Screening in a Pediatric Pain Management Center

Saroyan

Evans

Segoshi³

et al. 2016

The Clinical Journal of Pain

View full text Add to dashboard Cite

Objectives Many adolescents and young adults report having chronic pain. Urine drug toxicology (UDT) is not routinely used in the pediatric pain management population, despite more routine use in adults with pain, particularly those prescribed opioids. As a first step toward establishing monitoring practices in pediatric and adolescent pain management, the present study evaluated the role of UDT in conjunction with a standard clinical interview in identifying the rate of adherence to an established analgesic regimen. The study also aimed to assess the use of UDT in identifying possible aberrant behaviors in this population. Methods Data were acquired from a convenience sample of 50 pediatric and adolescent pain management initial consultations, during which a clinical interview and UDT were conducted. Data were analyzed to determine adherence to an established analgesic prescription regimen, and for identification of aberrant behaviors including concurrent use of illicit substances and prescription medication misuse. Other pertinent demographic and clinical factors were examined as factors in adherence. Results Opioid medications were prescribed for 42% of the sample receiving pain medications, and 22% of the sample was nonadherent to their prescription analgesic regimen. Factors associated with a higher likelihood of nonadherence were an older age and having an opioid prescription. The majority (90%) of those nonadherent to their analgesic regimen displayed some form of aberrant behavior. Among the nonadherent patients, 50% were identified by UDT alone, and 50% were identified by self-report during the clinical encounter. Conclusions These results highlight the challenges of identifying nonadherence to a prescription regimen among adolescents with chronic pain. In addition, this preliminary work suggests that UDT could be used in conjunction with careful clinical interviewing to substantiate patient report and increase the likelihood of detecting analgesic nonadherence and aberrant behaviors.

show abstract

“…9 Previous studies have documented several factors affecting adherence to AEDs in children and adolescents, but these have been done in developed countries or in tertiary care hospital settings. 10,11 There are no local studies, which have investigated the problem of nonadherence among children with epilepsy in Pakistan. Therefore, investigating the magnitude of the problem and the factors associated with nonadherence is essential in designing an appropriate health education strategy and having a plan to reduce the impact of the problem.…”

Section: Introductionmentioning

confidence: 99%

Medication Nonadherence in Children with Epilepsy Attending Outpatient Clinics in Under-Resourced Community

Malik¹,

Shabbir

Saeed

et al. 2015

J Pediatr Epilepsy

View full text Add to dashboard Cite

Nonadherence to epilepsy medications can interfere with treatment and may adversely affect clinical outcomes, although few studies have examined this relationship in childhood epilepsy in under-resource settings. Our aim was to determine the rate of anti-epileptic drugs (AEDs) nonadherence in families caring for a child or adolescent with epilepsy, and to describe some associated factors in under-resource settings. A cross-sectional snapshot descriptive study design was used. Interviewer-administered structured questionnaires were completed in a sample of 120 children with epilepsy on AEDs for at least 1?month prior to the registration attending outpatient visits at free pediatric neurology camps in under-resource settings. Information was obtained about adherence to antiepileptic regimens as well as factors influencing adherence to AED regimens. Drug adherence was suboptimal in 70 (58%) and satisfactory in 50 (42%) of the patients according to self or parental report. Age of the patient and caregiver did not significantly influence the drug compliance but adherence intention, and AED prescription patterns, adverse effects, availability of AEDs, seizure control, treating physician's counseling, financial constraints, and parental/caregiver's education were more significantly associated with drug nonadherence in these communities. The assessment of medication adherence in patient-oriented epilepsy treatment programs for patients with childhood epilepsy should be a routine part of the management process to promote self-management and are essential to maximize the treatment outcome.

show abstract

Adherence to antiepileptic drugs among children attending a tertiary health unit in a low resource setting

Cited by 27 publications

References 26 publications

Health service provision for people with epilepsy in sub-Saharan Africa: A situational review

Health service provision for people with epilepsy in sub-Saharan Africa: A situational review

Interviewing and Urine Drug Toxicology Screening in a Pediatric Pain Management Center

Medication Nonadherence in Children with Epilepsy Attending Outpatient Clinics in Under-Resourced Community

Contact Info

Product

Resources

About