Adherence to Antiretroviral Medication Among HIV-Positive Patients in Thailand

Maneesriwongul, Wantana; Tulathong, Somchit; Fennie, Kristopher; Williams, Ann B.

doi:10.1097/01.qai.0000248346.79888.78

Cited by 41 publications

(37 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The VAS has been validated in resource-limited settings (Maneesriwongul, Tulathong, Fennie, & Williams, 2006;Sarna et al, 2005). Adherence levels assessed from the VAS are defined as follows: full adherence 0100%; partial adherence ]95% and B100%; and non-adherence as B95% of prescribed doses taken in the past 30 days.…”

Section: Adherence Assessmentmentioning

confidence: 99%

Perceived stigma among patients receiving antiretroviral therapy: a prospective study in KwaZulu-Natal, South Africa

Peltzer

Ramlagan

2011

AIDS Care

View full text Add to dashboard Cite

The aim of this study is to examine whether internalized AIDS stigma among HIV patients one year after antiretroviral therapy (ART) initiation is associated with sociodemographic characteristics, health status, social support, quality of life (QoL), and ARV adherence. This is a prospective study of all treatment-naive patients (N=735) recruited from all three public hospitals in Uthukela health district in KwaZulu-Natal and followed up at 6 and 12 months being on ART. Results indicated that despite a decrease in stigma seen in this study (may be due to ART) the level of stigma and discrimination remains high, and stigma reduction interventions are urgently needed in this population. CD4 cell counts significantly increased and HIV symptoms reduced significantly but depression symptoms remained high and even increased after 12 months on treatment. In multivariate analysis lower CD4 cell counts (odds ratio 0.5, 0.3-0.9), severe depression (5.6, 2.5-12.5) and low QoL (0.6, 0.5-0.8) were associated with internalized AIDS stigma. These findings may suggest that HIV care should include counseling and support that includes stigma concerns, depression, and QoL prior to and during the first year following diagnosis.

show abstract

Section: Adherence Assessmentmentioning

confidence: 99%

Perceived stigma among patients receiving antiretroviral therapy: a prospective study in KwaZulu-Natal, South Africa

Peltzer

Ramlagan

2011

AIDS Care

View full text Add to dashboard Cite

show abstract

“…The 30-day visual analog scale (VAS) provided an overall adherence assessment for a longer time interval. Both have been validated in resource-limited settings (Maneesriwongul, 2006;Sarna et al, 2005). Adherence is calculated as the % of doses taken over those prescribed.…”

Section: Adherence Assessmentmentioning

confidence: 99%

Traditional complementary and alternative medicine and antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa

Peltzer¹,

Preez²,

Ramlagan³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Adherence to antiretroviral medication in the treatment of HIV is critical, both to maximize efficacy and to minimize the emergence of drug resistance. The aim of this prospective study in three public hospitals in KwaZuluNatal, South Africa, is to assess the use of Traditional Complementary and Alternative Medicine (TCAM) by HIV patients and its effect on antiretroviral (ARV) adherence 6 months after initiating ARVs. 735 (29.8% male and 70.2% female) patients who consecutively attended three HIV clinics completed assessments prior to ARV initiation and 519 after six months on antiretroviral therapy (ART) Results indicate that the use of herbal therapies for HIV declined significantly from 36.6% prior to antiretroviral treatment (ART) initiation to 7.9% after being on ARVs for 6 months. Faith healing methods, including spiritual practices and prayer for HIV declined from 35.8% to 22.1% and physical/body-mind therapy (exercise and massage) declined from 5.0% to 1.9%. In contrast, the use of micronutrients (vitamins, etc.) significantly increased from 42.6% to 87.4%. In multivariate regression analyses, ARV non-adherence (dose, schedule and food) was associated with the use of herbal treatment, not taking micronutrients and the use of over-the-counter drugs. The use of TCAM declined after initiating ARVs. As herbal treatment for HIV was associated with reduced ARV adherence, patients' use of TCAM should be considered in ARV adherence management.

show abstract

“…The VAS is a valid method of assessing medication adherence (Kalichman et al, 2009) and has been validated in resource-limited settings (e.g. Maneesriwongul et al, 2006). Adherence was calculated as the % of doses taken over those prescribed.…”

Section: Adherence Assessmentmentioning

confidence: 99%

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Peltzer

Preez²,

Ramlagan³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

The aim of this prospective study (20 months) was to assess HIV patients' use of Traditional, Complementary and Alternative Medicine (TCAM) and its effect on ARV adherence at three public hospitals in KwaZulu-Natal, South Africa. Seven hundred and thirty-five (29.8% male and 70.2% female) patients who consecutively attended three HIV clinics completed assessments prior to ARV initiation, 519 after 6 months, 557 after 12 and 499 after 20 months on antiretroviral therapy (ART). Results indicate that following initiation of ARV therapy the use of herbal therapies for HIV declined significantly from 36.6% prior to ARV therapy to 8.0% after 6 months, 4.1% after 12 months and 0.6% after 20 months on ARVs. Faith healing methods (including spiritual practices and prayer) declined from 35.8% to 22.1%, 20.8% and 15.5%, respectively. In contrast, the use of micronutrients (vitamins, etc.) significantly increased from 42.6% to 78.2%. The major herbal remedies that were used prior to ART were unnamed traditional medicine, followed by imbiza (Scilla natalensis planch), canova (immune booster), izifozonke (essential vitamins mixed with herbs), African potato (Hypoxis hemerocallidea), stametta (aloe mixed with vitamins and herbs) and ingwe (tonic). Herbal remedies were mainly used for pain relief, as immune booster and for stopping diarrhea. As herbal treatment for HIV was associated with reduced ARV adherence, patient's use of TCAM should be considered in ARV adherence management.

show abstract

Adherence to Antiretroviral Medication Among HIV-Positive Patients in Thailand

Abstract: Adherence was high in this cohort and was associated with HIV-RNA levels. However, these data confirm that adherence is only 1 factor that determines the effectiveness of ARV treatment. Duration of treatment was associated with virologic failure, controlling for adherence.

Cited by 41 publications

References 14 publications

Perceived stigma among patients receiving antiretroviral therapy: a prospective study in KwaZulu-Natal, South Africa

Perceived stigma among patients receiving antiretroviral therapy: a prospective study in KwaZulu-Natal, South Africa

Traditional complementary and alternative medicine and antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa

Antiretrovirals and the use of traditional, complementary and alternative medicine by HIV patients in KwaZulu-Natal, South Africa: a longitudinal study

Contact Info

Product

Resources

About