Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Govind, Kendre; Gabhale, Yashwant; Shah, Nikhil; Jadhav, Vishal; Nath, Kunal; Manglani, Mamta

doi:10.18203/2349-3291.ijcp20174154

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…28 Again, our finding is also similar to the finding of a study conducted in India that came up with, children whose caregivers had good knowledge about ART treatment were 14.7 times more adherent. 32 A similarly study conducted in north Ethiopia, justified our finding (AOR = 2.72). 33 Our finding is again in line with the study finding conducted at University of Gondar Hospital and Gondar Poly Clinic, which showed that children of knowledgeable caregivers had 4.7 times more adherent to ART than their counterparts (AOR = 4.7).…”

Section: Discussionsupporting

confidence: 85%

“… 31 However, the finding of the current study was higher than the finding of study conducted in India, which revealed an overall adherence of 82.1%. 32 This difference might be due to the study design (cross-sectional vs. cohort). It was also higher than that in a study in Uganda which reported an overall adherence status of 79.1%), 33 North Ethiopia, provided an adherence status of 78.6%, 22 and central Ethiopia showed an adherence rate of 74%.…”

Section: Discussionmentioning

confidence: 99%

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Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

Gemechu,

Hebo,

Kura

2023

HIV

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Background Poor adherence to antiretroviral therapy (ART) causes drug resistance, treatment failure and death. Studies conducted among children below 15 years were limited in Ethiopia in general and in the study area. Therefore, this study aimed to assess the status of children’s adherence to ART and associated factors in the study area. Methods We conducted a facility-based cross-sectional study from April 1 to May 10, 2020 by including 282 children <15 years. All children who received ART for at least one month and attend ART clinic during data collection period were consecutively recruited. Face-to-face interview was conducted using a standardized questionnaire. Both bivariate and multivariate logistic regression were performed. Adherence and exposure variables (i.e., sociodemographic and reason for missing) were measured by the caregivers/children’s report of a one-month recall of missed doses. Results Among 282 caregivers included with their children, 226 (80.2%) were females (mean age = 38.6 and SD = 12.35) and half (50%) of children were females. Two hundred forty six (87.2%) children were aged between 5–14 years (mean age = 8.5 and SD = 2.64), and 87.2% were adhered (≥95%) to ART in the month prior to the interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than their counterparties. Children whose caregivers were biological parents were 2.37 (95% CI: 1.59, 3.3) times more adherent than children with non-biological parents. Children with knowledgeable caregivers about ART were 4.5 (95% CI: 1.79, 9.8) times more adherent to ART. Conclusion and Recommendation Children’s adherence to ART in our study area was sub optimal. Biological caregivers, residing in urban and being knowledgeable about ART facilitate adherence to ART. Adherence counseling targeting non-biological parents and for those who come from rural areas were recommended.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

Gemechu,

Hebo,

Kura

2023

HIV

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“…Hospital and Gondar Poly Clinic, 90.4% (23), Addis Ababa 86.9% (24). But the nding of current study was higher than the nding of the study conducted by Govind M. et al in India, that revealed an overall adherence of 82.1% (25). This difference might be due to study design (cross sectional vs cohort).…”

Section: Discussioncontrasting

confidence: 67%

“…Our nding is similar to the study nding conducted in Hiwot Fana and Dil-Chora hospital that revealed caregivers of children with good knowledge about the disease were 7.3 times [AOR = 7.3] adherent than their counter parts(21). Again our nding is also similar to the nding of study conducted in India that came up with, children whose caregivers have good knowledge about ART treatment were 14.7 times more adherent(25). Similarly study conducted in south Wollo zone was justify Current study also provided that children residing in urban area were 3.2 times more adherent to ART than those who residing in rural.…”

supporting

confidence: 86%

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multi-center Cross-sectional Study

Gemechu

Habtamu

Zarihun

2022

Preprint

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Background- Sub- optimal adherence to antiretroviral therapy will lead drug resistance, treatment failure, clinical deterioration, death and failure to thrive in children. Studies conducted among children below 15 years old were limited in Ethiopia in general and in study area in particular. Therefore, this study was aimed to assess status of children’s adherence to ART and associated factors in study area. Methods- We conduct a facility-based cross-sectional study by including total of 282 children <15 years, who received Anti retro viral therapy for at least one month. All children/caregivers who were attending ART clinic during data collection period were consecutively recruited to the study. Both bivariate and multivariate logistic regression were performed. Result- Out of 282 caregivers included with their children, 226(80.2%) were females (mean age= 38.6 and SD = 12.35) and out of the total children, half (50%) were female and 246(87.2%) were between the ages 5–14 years (mean age= 8.5 and SD = 2.64). Two hundred forty six (87.2%) children had adherence status of ≥95% in the month prior to interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than those whose caregivers were residing in rural. Children whose caregivers were biological parent were 2.37(95% CI: 1.59, 3.3) times more adherent than those whose caregivers were non biological parent. Also children of caregivers who were knowledgeable about ART treatment, were 4.5(95% CI: 1.79, 9.8) times more adherent to ART than their counter partsConclusion and recommendation- Adherence status of children in our study area was comparable. Being biological caregivers, residing in urban and knowledgeable about ART treatment were facilitate adherence to ART. Ongoing education about treatment and further study with multiple adherence assessment method were recommended.

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Assessment of Adherence to Antiretroviral Therapy, Associated Factors, and Relationship to CD4 Cell Count Recovery among HIV-Positive Adolescents

Ugochukwu

Ogbuefi

Onubogu

et al. 2021

Nigerian Journal of Medicine

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Background: Adherence to antiretroviral therapy (ART) in HIV-positive adolescents (HPAs) is an enormous challenge in pediatric HIV management. Suboptimal adherence (OA) encourages treatment failure and HIV transmission. Several factors are inimical to OA, among HPA. Objective: The factors which influence adherence to ART in HPA accessing care in Nnewi, Nigeria, were determined. Subjects and Methods: One hundred and fifty HPAs, aged 10–19 years, who had been on ART for at least 6 months were recruited; 75 each for groups 10–14 and 15–19 years. Sociodemographic data were collected using interviewer-administered questionnaires. Relevant clinical data were retrieved from medical records, and current CD4 cell counts assayed. Results: There were 77 males and 73 females. OA to ART was defined as intake of ≥95% of antiretrovirals over a given period. Using pill count (PC), 74.7% (112/150) had OA. Using the preceding 28-day self-report (P28DSR), 84.0% (126/150) had OA, while for the preceding seven-day self-report (P7DSR), it was 89.3% (134/150). Factors significantly associated with sub-OA were tertiary education, missed clinic visits, travel time to facility ≤1 h, persistent feeling of sadness, and fear of death. Subjects with OA had a significantly higher rate of CD4 cell count recovery compared to those having sub-OA. Conclusion: Sub-OA is common in HPA and can be assessed with a combination of PC and preceding P28DSR, in resource-poor settings. As OA is crucial to CD4 cell count recovery, the latter can be useful in monitoring adherence in HPA.

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Adherence to antiretroviral therapy and factors affecting adherence among paediatric HIV patients

Cited by 3 publications

References 19 publications

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study

Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multi-center Cross-sectional Study

Assessment of Adherence to Antiretroviral Therapy, Associated Factors, and Relationship to CD4 Cell Count Recovery among HIV-Positive Adolescents

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