Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a systematic review

Malta, Mônica; Strathdee, Steffanie A.; Magnanini, Mônica Maria Ferreira; Bastos, Francisco I.

doi:10.1111/j.1360-0443.2008.02269.x

Cited by 259 publications

(187 citation statements)

References 65 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…In planning our recent systematic review (Malta et al 2008) and meta-analysis, we reviewed standard guidelines to conduct and report meta-analysis studies, which included the consolidated standards of reporting trials-CONSORT Moher et al 2001), the quality of reporting of meta-analyses-QUOROM (Moher et al 2000), the meta-analysis of observational studies in epidemiology (MOOSE) group , and the transparent reporting of evaluations with nonrandomized designs-TREND (Des Jarlais et al 2004). Since many of the selected studies were observational studies rather than clinical trials, the MOOSE recommendations were used to conduct and report the meta-analysis, while the TREND checklist (Version 1.0) was used as a guide for data abstraction.…”

Section: Methodsmentioning

confidence: 99%

“…However, other studies have found that HIVpositive drug users who have access to drug abuse and mental health treatment (Malta et al 2008), and particularly former drug users who are abstinent, can attain the same levels of adherence found among PLWHA who have never used illicit drugs (Crystal et al 2001) and can thus achieve similar survival rates compared to non-drug using populations (Wood et al 2008).…”

Section: Introductionmentioning

confidence: 91%

“…A former review paper by our group summarized the main barriers and facilitators of adherence among drug using populations (Malta et al 2008). In this meta-analysis, we synthesize the available scientific literature, presenting a pooled measurement of adherence among HIV-positive DU accounting for between-study heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

et al. 2008

Self Cite

View full text Add to dashboard Cite

We conducted a meta-analysis of studies assessing adherence to highly active antiretroviral therapy (HAART) and a qualitative systematic review of factors associated with better HAART outcomes among HIV+ drug users (DU). Thirty-eight studies were considered, which analyzed 14,960 patients (11,394 HIV+ DU, 76.2%). Overall adherence (pooled percent of DU classified as adherent in each study) was 0.60 (95% CI: 0.52-0.68), similar to levels identified by studies conducted with HIV+ patients who are not drug users. Time frame used to measure adherence was an independent predictor of inter-study heterogeneity. The systematic review identified better HAART outcomes among former DU, those with less severe psychiatric conditions, those receiving opioid substitution therapy and/or psychosocial support. Patients initiating HAART with lower viral load and higher CD4 counts, and those without co-infections also had better treatment outcomes. Our findings suggest that HIV+ DU tend to be inappropriately assumed to be less adherent and unlikely to achieve desirable treatment outcomes, when compared to their non-DU cohort.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…El uso terapéutico de la misma, al menos en nuestro país, podría corresponderse con sujetos clínicamente más deteriorados o con un perfil socioeconómico más bajo (Ladero, Orejudo y Carrobles, 2005), lo que explicaría una peor adherencia y resultaría congruente con los resultados obtenidos. No obstante, estudios previos han planteado que la pertenencia a un programa terapéutico con metadona, frente a usuarios de drogas por vía parenteral sin seguimiento, podría suponer una mejora en la adherencia al tratamiento antirretroviral (Malta, Strathdee, Magnanini y Bastos, 2008), sobre todo en zonas marginales con elevada prevalencia de este tipo de consumo .…”

Section: Discussionunclassified

Relación entre la adherencia al tratamiento antirretroviral en pacientes VIH+ y el consumo de alcohol, asociado o no al uso de otras sustancias

et al. 2017

View full text Add to dashboard Cite

ResumenHazardous alcohol consumption is a common diagnosis among people living with HIV infection. The relationship between alcohol consumption and poor adherence to antiretroviral therapy has been highlighted in different studies, yet few of them performed a parallel analysis of other substance use. In Spain, alcohol consumption is frequently associated with other substance use, mainly cannabis and cocaine. The aim of this study is to assess the influence of hazardous alcohol consumption both combined with other substances (cocaine, heroin, methadone and/or cannabis) or alone on antiretroviral therapy adherence in our social environment. We performed an observational case-control study including 119 HIV+ individuals. We recruited 40 non-adherent patients, defined by less than 90% compliance according to hospital pharmacy refill data, and corroborated by the

show abstract

“…Yet, social support can address ART adherence concerns in drug-abusing and homeless populations. 34,35 And although the 2008 OARAC guidelines noted insufficient evidence regarding the timing of ART during TB treatment, recent studies demonstrate that ART during TB therapy reduces TB mortality among the most immunocompromised individuals in developing country settings. [36][37][38][39] As a result, OARAC released updated guidelines in 2012 formally recommending ART initiation within two weeks of TB treatment initiation for patients with 50 CD4 cells/mm 3 , 2-4 weeks after TB treatment initiation for those with severe clinical disease, and 8-12 weeks after TB treatment initiation for those without severe clinical disease.…”

Section: Discussionmentioning

confidence: 99%

Timely HIV Diagnosis and HIV/TB Comanagement among California Patients in 2008

et al. 2014

View full text Add to dashboard Cite

Objective. National guidelines highlight the roles of early HIV diagnosis and effective comanagement for HIV and tuberculosis (TB) to prevent mortality and morbidity from HIV-related TB. We assessed HIV diagnosis timing and HIV/TB comanagement for California HIV/TB patients.Methods. We reviewed and analyzed public health charts for California HIV/TB patients reported during 2008. HIV diagnoses fewer than three months before TB diagnosis were considered new HIV diagnoses. We determined the proportion of patients with new HIV diagnoses, risk factors for new HIV diagnoses, and proportion of patients receiving recommended CD4 cell count measurements, supervised TB therapy, and antiretroviral therapy (ART).results. Of 130 HIV/TB patients, 51% had new HIV diagnoses. Foreign-born patients were more likely than U.S.-born patients to have new HIV diagnoses. Supervised TB therapy and CD4 cell count measurements followed national recommendations for 91% and 74% of patients, respectively. At least 73% of patients started ART before completing TB therapy. Compared with patients who had previous HIV diagnoses, patients with new HIV diagnoses started ART later and had lower CD4 cell counts and higher viral loads at TB diagnosis.conclusions. Although most HIV/TB patients received the recommended treatment, half had new HIV diagnoses. Compared with patients who had previous HIV diagnoses, patients with new HIV diagnoses had greater immunosuppression at TB diagnosis. A new diagnosis indicates that HIV could have been diagnosed earlier and ART or treatment for latent TB infection could have been initiated to prevent TB development.

show abstract

Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: a systematic review

Cited by 259 publications

References 65 publications

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

Relación entre la adherencia al tratamiento antirretroviral en pacientes VIH+ y el consumo de alcohol, asociado o no al uso de otras sustancias

Timely HIV Diagnosis and HIV/TB Comanagement among California Patients in 2008

Contact Info

Product

Resources

About