Adherence to Antiretroviral Therapy in People Living with HIV/AIDS: A Cross-Sectional Study

Bomfim, Isabella Gerin de Oliveira; Santos, Suelen Silvana dos; Napoleão, Anamaria Alves

doi:10.1089/apc.2022.0056

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Antiretroviral therapy has revolutionized HIV treatment, but its success is dependent on adherence. Studies utilizing medication dispensation data from high and middle-income countries have reported ART adherence ranging from 61.8 to 83.6% [24][25][26] . Here, we report much lower ART adherence rates (16.4%) for a historically neglected and underreported population: those burdened simultaneously with HIV/AIDS and psychiatric conditions 9,10,27 .…”

Section: Discussionmentioning

confidence: 99%

Adherence to antiretroviral therapy in people living with HIV with moderate or severe mental disorder

Arashiro

Maciel²,

Freitas³

et al. 2023

Sci Rep

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Human immunodeficiency virus (HIV) infection remains a serious public health concern, with an estimated 38 million people living with HIV (PLHIV). PLHIV are often affected by mental disorders at higher rate than the general population. One challenge in the control and prevention of new HIV infections is adherence to antiretroviral therapy (ART), with PLHIV with mental disorders having seemingly lower adherence than PLHIV without mental disorders. This cross-sectional study assessed adherence to ART in PLHIV with mental disorders who attended the Psychosocial Care Network health facilities in Campo Grande, Mato Grosso do Sul, Brazil, from January 2014 to December 2018. Data from health and medical databases were used to describe clinical–epidemiological profiles and adherence to ART. To assess the associated factors (potential risk or predisposing factors) with ART adherence, we used logistic regression model. Adherence was extremely low (16.4%). Factors associated with poor adherence were lack of clinical follow-up, particularly in middle-aged PLHIV. Other apparently associated factors were living on the streets and having suicidal ideation. Our findings reinforce the need for improvements in the care for PLHIV with mental disorders, especially in the integration between specialized mental health and infectious disease health facilities.

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Section: Discussionmentioning

confidence: 99%

Adherence to antiretroviral therapy in people living with HIV with moderate or severe mental disorder

Arashiro

Maciel²,

Freitas³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

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“…Although HIV diagnoses among women are on the decline in the U.S., nearly 20% of incident cases occurred among women in 2020 [22]. In addition, men and women living with HIV often have differing HIV engagement experiences [23] and patterns of ART adherence [24,25]. For example, a retrospective cohort of 33,224 PWH found that women were less likely to be engaged in HIV medical care, prescribed ART, and virally suppressed than men [26].…”

Section: Introductionmentioning

confidence: 99%

Substance Use and Adherence to Antiretroviral Therapy among People Living with HIV in the United States

et al. 2022

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People with HIV (PWH) report substance use at higher rates than HIV-uninfected individuals. The potential negative impact of single and polysubstance use on HIV treatment among diverse samples of PWH is underexplored. PWH were recruited from the Center for Positive Living at the Montefiore Medical Center (Bronx, NY, USA) from May 2017-April 2018 and completed a cross-sectional survey with measures of substance use, antiretroviral therapy (ART) use, and ART adherence. The overall sample included 237 PWH (54.1% Black, 42.2% female, median age 53 years). Approximately half of the sample reported any current substance use with 23.1% reporting single substance use and 21.4% reporting polysubstance use. Polysubstance use was more prevalent among those with current cigarette smoking relative to those with no current smoking and among females relative to males. Alcohol and cannabis were the most commonly reported polysubstance combination; however, a sizeable proportion of PWH reported other two, three, and four-substance groupings. Single and polysubstance use were associated with lower ART adherence. A thorough understanding of substance use patterns and related adherence challenges may aid with targeted public health interventions to improve HIV care cascade goals, including the integration of substance use prevention into HIV treatment and care settings.

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“…Embora a utilização da TARV conforme prescrito possa diminuir ou suprimir suficientemente a carga viral de um indivíduo, o que é essencial para manutenção da saúde das PVHIV 11 , estudo realizado no interior de São Paulo apontou uma taxa de adesão à TARV (62%) 12 . Por sua vez, estudo de coorte que avaliou a não adesão à TARV em serviços de referência em Pernambuco, encontrou taxa de adesão de 85,5% 13 .…”

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Para além da busca ativa: motivações para retorno ao tratamento de HIV [Beyond active search: motivations for returning to HIV treatment] [Más allá de la búsqueda activa: motivaciones para volver al tratamiento del VIH]

et al. 2022

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Objetivo: apreender aspectos que influenciam no abandono do tratamento e que mobilizam a disposição para retomá-lo, na perspectiva de pessoas que vivem com HIV. Método: estudo qualitativo, realizado em um serviço ambulatorial, com dados coletados entre abril e agosto de 2021, após aprovação pelo Comitê de Ética em Pesquisa, mediante consulta aos prontuários e entrevistas com 24 usuários, submetidas à análise de conteúdo. Resultados: os motivos para o abandono do tratamento referidos com maior frequência foram isolamento social imposto pela pandemia, dificuldade de acesso/locomoção até o serviço e efeitos colaterais dos medicamentos. O desejo de sentir-se saudável, desempenhar papeis sociais, cultivar laços familiares, reconhecer que já superou fases piores e o sentimento de mais valia após busca ativa, foram as motivações para retorno ao serviço. Considerações finais: os resultados apontam a importância do atendimento individualizado para conhecer as motivações de retorno ao tratamento as quais oferecem subsídios para o planejamento de ações de busca ativa.ABSTRACTObjective: to identify factors that influence the decision to abandon treatment or foster a willingness to resume it, from the perspective of persons living with HIV. Method: this qualitative study was carried out between April and August 2021 in an outpatient service, after approval by the research ethics committee. Data were collected by consulting medical records and interviewing 24 users, and were treated by content analysis. Results: reasons for abandoning treatment most frequently mentioned were the social isolation imposed by the pandemic, difficulty in accessing or commuting to the service, and the drugs’ side effects. The motivations for returning to the service were the desire to feel healthy, play social roles, cultivate family ties, recognize that he has overcome worse phases and the feeling of added value after active search. Final considerations: the findings point to the importance of individualized care to understanding the motivations for returning to treatment, which can inform the planning of active search actions.RESUMENObjetivo: comprender aspectos que influyen en el abandono del tratamiento y que movilizan la voluntad para retomarlo, en la perspectiva de las personas que viven con VIH. Método: estudio cualitativo, realizado en un servicio de consulta externa, con datos recolectados entre abril y agosto de 2021, después de la aprobación del Comité de Ética en Investigación, mediante consulta de historias clínicas y entrevistas con 24 usuarios, sometidos a análisis de contenido. Resultados: los motivos de abandono del tratamiento mencionados más frecuentemente fueron el aislamiento social impuesto por la pandemia, la dificultad de acceso/traslado al trabajo y los efectos secundarios de los medicamentos. El deseo de sentirse saludable, desempeñar roles sociales, cultivar lazos familiares, entender que ha superado fases peores y la sensación de plusvalía luego de una búsqueda activa, fueron las motivaciones para volver al servicio. Consideraciones finales: los resultados apuntan hacia la importancia de la atención individualizada para comprender las motivaciones de retorno al tratamiento, que ofrecen subsidios para la planificación de acciones de búsqueda activa.

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Adherence to Antiretroviral Therapy in People Living with HIV/AIDS: A Cross-Sectional Study

Cited by 6 publications

References 26 publications

Adherence to antiretroviral therapy in people living with HIV with moderate or severe mental disorder

Adherence to antiretroviral therapy in people living with HIV with moderate or severe mental disorder

Substance Use and Adherence to Antiretroviral Therapy among People Living with HIV in the United States

Para além da busca ativa: motivações para retorno ao tratamento de HIV [Beyond active search: motivations for returning to HIV treatment] [Más allá de la búsqueda activa: motivaciones para volver al tratamiento del VIH]

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