Adherence to Antiretroviral Treatment Among People Who Started Treatment on the Same-Day of HIV Diagnosis in Ethiopia: A Multicenter Observational Study

Ahmed, Ismael; Demissie, Meaza; Worku, Alemayehu; Gugsa, Salem; Berhane, Yemane

doi:10.2147/hiv.s337073

HIV

2021

DOI: 10.2147/hiv.s337073

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Adherence to Antiretroviral Treatment Among People Who Started Treatment on the Same-Day of HIV Diagnosis in Ethiopia: A Multicenter Observational Study

Ismael Ahmed¹,

Meaza Demissie²,

Alemayehu Worku³

et al.

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2024

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References 37 publications

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Rapid antiretroviral therapy and treatment outcomes among people living with HIV: exploring the mediating roles of medication adherence

Chen,

Tao,

et al. 2024

Front. Public Health

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IntroductionThe rapid initiation of antiretroviral therapy (ART) and its impact on treatment outcomes have been a subject of global public health interest. However, the precise mechanisms underlying the effects of rapid ART initiation remain unclear.MethodsThis retrospective cohort study examined data from 1846 HIV-infected individuals in Jiulongpo District, Chongqing, China, spanning from 2016 to 2022. Logistic regression models and serial mediation analysis were used to explore the influence of rapid ART initiation on treatment outcomes and the role of medication adherence as a mediating factor.ResultsThe findings revealed a significant association between rapid ART initiation and reduced risk of viral failure (adjusted odds ratio [OR] = 0.320, 95% confidence interval [CI] = [0.161, 0.637]), as well as an increased likelihood of improved adherence (adjusted OR = 2.053, 95% CI = [1.226, 3.438]). Medication adherence was identified as a partial mediator in the relationship between rapid ART initiation and viral failure, explaining 10.5% of the total effect.DiscussionIn conclusion,rapid initiation of antiretroviral therapy was found to enhance treatment outcomes, emphasizing the importance of early adherence education. The study recommends early initiation of ART coupled with adherence education and psychological counseling for HIV-infected individuals.

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Rapid antiretroviral therapy and treatment outcomes among people living with HIV: exploring the mediating roles of medication adherence

Chen,

Tao,

et al. 2024

Front. Public Health

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Adherence to Antiretroviral Treatment Among People Who Started Treatment on the Same-Day of HIV Diagnosis in Ethiopia: A Multicenter Observational Study

Cited by 1 publication

References 37 publications

Rapid antiretroviral therapy and treatment outcomes among people living with HIV: exploring the mediating roles of medication adherence

Rapid antiretroviral therapy and treatment outcomes among people living with HIV: exploring the mediating roles of medication adherence

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