Adherence to Antiretroviral Treatment and Associated Factors among Seropositive People Received Treatment in Jimma Town Public Health Facilities, Ethiopia

Demas, Zenash; Gebremariam, Abebe; Kebede, Ayantu; Woldasemayat, Lalisa Ayele

doi:10.1177/23259582221121096

Cited by 2 publications

(9 citation statements)

References 16 publications

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“…The forty-two studies [ 1 – 3 , 5 , 6 , 8 – 10 , 18 , 19 , 27 , 29 , 34 , 43 , 44 , 52 – 78 ], two studies [ 79 , 80 ] and one study [ 35 ] were conducted using cross-sectional, retrospective cohort and case-control studies respectively. Regarding geographical region, fourteen studies were conducted in Oromia [ 2 , 3 , 9 , 18 , 27 , 44 , 52 , 57 , 59 , 64 , 69 , 76 , 77 , 79 ], eleven studies in Amhara [ 1 , 6 , 19 , 56 , 61 , 66 – 68 , 73 , 75 , 78 ], ten studies in Southern nations nationalities [ 5 , 10 , 34 , 35 , 43 , 53 , 55 , 60 , 62 , 72 ], two studies in Addis Ababa [ 8 , 44 ], two studies in Tigray [ 58 , 80 ], one study in Oromia and Southern nations nationalities [ 54 ], one study in Harari and Dire Dawa [ 63 ] and one study was conducted in each Benishangul Gumuz [ 71 ], Somali [ 74 ], Harari [ 29 ], and Sidama region [ 65 ]. The total sample size of ...…”

Section: Resultsmentioning

confidence: 99%

“…The total sample size of the included studies was 36,317, where the smallest sample size was 81 in Southern nations and nationalities and the largest sample size was also 19,525 in Tigray region health research institute. The prevalence of non-adherence to ART was obtained from forty-four included primary studies [ 1 – 3 , 5 , 6 , 8 – 10 , 18 , 19 , 27 , 29 , 34 , 43 , 44 , 52 – 80 ], while the data regarding the predictors of non-adherence to ART were obtained from the thirty-five studies [ 1 , 2 , 5 , 6 , 8 , 18 , 19 , 27 , 29 , 35 , 44 , 53 – 55 , 57 – 61 , 63 – 69 , 71 – 74 , 76 – 80 ], with a response rate ranges from 87 to 100% (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The quality of each study was evaluated using the Joanna Briggs Institute (JBI) quality appraisal criteria [ 81 ]. Forty-two studies [ 1 – 3 , 5 , 6 , 8 – 10 , 18 , 19 , 27 , 29 , 34 , 43 , 44 , 52 – 78 ], two studies [ 79 , 80 ] and one study [ 35 ] were appraised using JBI checklist for cross-sectional, cohort and case-control studies respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Non-adherence to ART is the condition of missing doses completely, not following the information given by the health care providers and taking drugs inappropriately [ 9 , 18 , 34 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

“…Adherence to ART is the patient’s ability to follow treatment plan by taking the correct dose of medications (≥ 95% of the prescribed doses) at prescribed time, frequencies (schedule) and following dietary instructions [ 9 , 18 , 34 , 35 ]. It is strongly correlated with suppression of the disease and reduction of morbidity and mortality rates among people living with HIV [ 36 – 38 ], and the clinical outcomes of ART mainly depends on the adherence of patients to ART [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis

Aytenew,

Demis,

Birhane

et al. 2023

AIDS Behav

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Human immunodeficiency virus remains a global public health problem. Despite efforts to determine the prevalence of non-adherence to ART and its predictors in Ethiopia, various primary studies presented inconsistent findings. Therefore, this review aimed to determine the pooled prevalence of non-adherence to ART and identify its predictors. We have searched PubMed, Google Scholar and Web of Science databases extensively for all available studies. A weighted inverse-variance random-effects model was used to compute the overall non-adherence to ART. The pooled prevalence of non-adherence to ART was 20.68% (95% CI: 17.74, 23.61); I2 = 98.40%; p < 0.001). Educational level of primary school and lower [AOR = 3.5, 95%CI: 1.7, 7.4], taking co-medications [AOR = 0.45, 95%CI: 0.35, 0.59], not using memory aids [AOR = 0.30, 95%CI: 0.13, 0.71], depression [AOR = 2.0, 95%CI: 1.05, 3.79], comorbidity [AOR = 2.12, 95%CI: 1.16, 3.09), under-nutrition [AOR = 2.02, 95%CI: 1.20, 3.43], not believing on ART can control HIV [AOR = 2.31, 95%CI: 1.92, 2.77], lack of access to health facilities [AOR = 3.86, 95%CI: 1.10, 13.51] and taking ART pills uncomfortably while others looking [AOR = 5.21, 95%CI: 2.56, 10.53] were significantly associated with non-adherence to anti-retroviral therapy. The overall pooled prevalence of non-adherence to ART was considerably high in Ethiopia. Educational status, taking co-medications, not using memory aids, depression, comorbidity, under nutrition, not believing on anti-retroviral therapy controls HIV, lack of access to health facilities and taking ART pills uncomfortably were independent predictors of non-adherence to ART in Ethiopia. Therefore, healthcare providers, adherence counselors and supporters should detect non-adherence behaviors and patients’ difficulties with ART early, and provide intensive counseling to promote adherence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Non-adherence to ART is the condition of missing doses completely, not following the information given by the health care providers and taking drugs inappropriately [ 9 , 18 , 34 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis

Aytenew,

Demis,

Birhane

et al. 2023

AIDS Behav

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Factors associated with adherence to antiretroviral therapy among HIV-positive adolescents and young adult patients attending HIV care and treatment clinic at Bombo Hospital in Tanga region-Tanzania

Kamote,

Tesha,

Sunguya

2025

PLoS ONE

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Background Adherence to HIV treatment regimens involves the consistent and correct intake of all prescribed medications. The implementation of antiretroviral therapy (ART) program has significantly reduced mortality among adolescents living with HIV. However, adherence to ART is lower among adolescents compared to other sub-populations and even lower in sub-Saharan Africa. The factors influencing ART adherence are context-specific and vary across countries and regions. In the Tanzanian context, there is a paucity of data regarding these factors. Methodology This cross-sectional study involved 385 adolescents and young adults living with HIV receiving treatment at Bombo Hospital Referral Hospital’s Care and Treatment Clinic, in Tanga, Tanzania. To assess adherence, a one-month self-recall medication adherence scale was used while a structured questionnaire was used to gather data on determinants of adherence. Data were collected using Google Forms and subsequently exported as a Microsoft Excel file. The data were then entered into Stata software version 15 for cleaning for descriptive and logistic regression analyses. Results More than a third (35.3%) of adolescents and young adults living with HIV in Tanga were not adherent to the effective and available ART. Adolescents and young adults living in households experiencing moderate food insecurity were 67% less likely to adhere to ART (95%CI 0.16–0.66) compared to those who were food secure. Those with secondary education were 2.3 times more likely to adhere to ART (95%CI 1.02–5.23), compared to those without formal education. While participants who consistently obtain their ART at the clinic were more 4.2 times more likely to adhere to medication (95%CI 1.29–13.72), those experiencing ART side effects were 39% less likely to adhere to ART (95%CI 0.38–0.98). Conclusion More than one-third of adolescents and young adults were not adherent to ART in Tanga, Tanzania. Addressing such unprecedented challenges calls for efforts targeting adolescents and young adults with limited education, from households with food insecurity, and ensuring counseling and management of ART side effects.

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Adherence to Antiretroviral Treatment and Associated Factors among Seropositive People Received Treatment in Jimma Town Public Health Facilities, Ethiopia

Cited by 2 publications

References 16 publications

Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis

Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis

Factors associated with adherence to antiretroviral therapy among HIV-positive adolescents and young adult patients attending HIV care and treatment clinic at Bombo Hospital in Tanga region-Tanzania

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