Adherence to CONSORT Items in Randomized Controlled Trials of Integrative Medicine for Colorectal Cancer Published in Chinese Journals

Chen, Menghua; Cui, Jing; Zhang, Anthony Lin; Xue, Charlie Changli; May, Brian H.

doi:10.1089/acm.2017.0065

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…Nevertheless, the results of the multiple sham-controlled studies tended to agree with those of the nonblinded studies. Many studies conducted in China do not report according to the CONSORT or STRICTA guidelines, resulting in omission of important aspects of trial methodology [ 37 , 53 ]. From the point of view of meta-analysis, inadequacies in study reporting substantially limit the opportunities for exploration of clinically relevant variables [ 54 ], so it is vital that journals endorse these guidelines.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Liu

May

Zhang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Delays in recovery of intestinal function following abdominal surgery are associated with longer hospital stays, increased postoperative complications, and higher costs to the health care system. Studies of acupuncture for postoperative ileus and other postoperative issues have reported improvements. This systematic review and meta-analysis aimed to assess whether acupuncture assisted recovery following surgery for colorectal cancer (CRC). Randomized controlled trials (RCTs) were identified from major English and Chinese language biomedical databases. Participants (aged 18 years plus) had received surgical resection for CRC. 22 studies (1,628 participants) were included. Five were sham-controlled. Outcomes included gastrointestinal function recovery (21 studies), recovery of urinary function (1 study), postoperative abdominal distension (3 studies), and quality of life (1 study). Meta-analyses found significant reductions in time to first bowel sounds, first flatus, and first defecation in both the sham-controlled and nonblinded studies. These results suggested that the addition of acupuncture following CRC surgery improved recovery of gastrointestinal function based on four blinded good quality RCTs (281 participants) and 17 nonblinded lower quality RCTs (1,265 participants). The best available evidence was for interventions that included electroacupuncture at the point ST36 Zusanli and there is supporting evidence for other types of acupuncture therapies that involve stimulation of this point. This review is registered with the following: systematic review registration in PROSPERO: CRD42017079590.

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Section: Discussionmentioning

confidence: 99%

Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Liu

May

Zhang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…These issues can be explored in specific fields, journals, databases, geographical regions and time periods. For example, Areia et al explored the quality of reporting of endoscopic diagnostic studies in gastroenterology [25]; Knol et al investigated the reporting of p-values in baseline tables in randomized trial published in high impact journals [26]; Chen et al describe adherence to the Consolidated Standards of Reporting Trials (CONSORT) statement in Chinese Journals [27]; and Hopewell et al describe the effect of editors' implementation of CONSORT guidelines on reporting of abstracts over time [28]. Methodological studies provide useful information to researchers, clinicians, editors, publishers and users of health literature.…”

Section: Why Do We Conduct Methodological Studies?mentioning

confidence: 99%

A tutorial on methodological studies: the what, when, how and why

Mbuagbaw

Lawson

Puljak

et al. 2020

BMC Med Res Methodol

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Background Methodological studies – studies that evaluate the design, analysis or reporting of other research-related reports – play an important role in health research. They help to highlight issues in the conduct of research with the aim of improving health research methodology, and ultimately reducing research waste. Main body We provide an overview of some of the key aspects of methodological studies such as what they are, and when, how and why they are done. We adopt a “frequently asked questions” format to facilitate reading this paper and provide multiple examples to help guide researchers interested in conducting methodological studies. Some of the topics addressed include: is it necessary to publish a study protocol? How to select relevant research reports and databases for a methodological study? What approaches to data extraction and statistical analysis should be considered when conducting a methodological study? What are potential threats to validity and is there a way to appraise the quality of methodological studies? Conclusion Appropriate reflection and application of basic principles of epidemiology and biostatistics are required in the design and analysis of methodological studies. This paper provides an introduction for further discussion about the conduct of methodological studies.

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“…Colorectal cancer is the third most common cancer in the world and the second leading cause of cancer-related death ( Chen et al, 2018 ). In China, the incidence and mortality rate of colorectal cancer are on the rise, and colorectal cancer ranks among the five most common malignant tumors in all regions.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy and safety of Chinese medicine injections combined with capecitabine and oxaliplatin chemotherapies in treatment of colorectal cancer: A bayesian network meta-analysis

Liu

Zhang

2022

Front. Pharmacol.

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Objective: The aim of the present Bayesian network meta-analysis (NMA) was to explore the comparative effectiveness and safeaty of different Chinese Medicine injections (CMIs) combined with the XELOX regimen versus XELOX alone for colorectal cancer (CRC).Methods: A comprehensive search for randomized controlled trials (RCTs) was performed with regard to different CMIs for the treatment of CRC in several electronic databases up to April 2022. The quality assessment of the included RCTs was conducted according to the Cochrane risk of bias tool. Standard pair-wise and Bayesian NMA were designed to comparethe effectiveness and safety of different CMIs combined with the XELOX regimen by utilizing R 4.0.3 software and Stata 15.1 software simultaneously.Results: Initially, a total of 4296 citations were retrieved through comprehensive searching, and 32 eligible articles involving 2847 participants and 11 CMIs were ultimately included. CMIs combined with XELOX were superior to the XELOX regimen alone, and a total of ten Observation Indicators were included in the study, with the following results. Among all the injections, Shengmaiyin, Shenmai, and Kanglaite combined with the XELOX regimen were the three CMIs with the highest clinical efficiency. The top three in terms of improving CD3+ values were Shengmaiyin, Shenqifuzheng, and Cinobufacini injections. Shenqifuzheng, Shengmaiyin, and BruceaJavanica oil injections combined with the XELOX regimen performed best at raising CD4+ values. Kanglaite, Cinobufacini, and Matrine injections combined with the XELOX regimen performed best in improving CD4+/CD8+ rates. The top three in terms of improving performance status were Xiaoaiping, Shenmai, and Kanglaite injections. Cinobufacini and Brucea Javanica oil injections combined with the XELOX regimen performed best at raising CD8+ values. Shenqifuzheng, Kangai, and Matrine injections combined with the XELOX regimen performed best in improving Gastrointestinal reactions.The top threein terms of improving Leukopenia were Shenqifuzheng, Compound Kushen and Kanglaite injections. The top three in terms of improving Platelet decline were Compound Kushen, Cinobufacini and Shenqifuzheng injections. Additionally, those that were best at improving nausea and vomitting were Cinobufacini, Compound Kushen and Aidi injections.Conclusion: The results of the analysis demonstrated thatShengmaiyin, Kanglaite, and Cinobufacini injections and the XELOX regimen were associated with morepreferable and beneficial outcomes than other CMI groups. Nevertheless, additional results from multicenter trials and high-quality studies will bevital to support our findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=326097, CRD42022326097.

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Adherence to CONSORT Items in Randomized Controlled Trials of Integrative Medicine for Colorectal Cancer Published in Chinese Journals

Cited by 7 publications

References 35 publications

Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

A tutorial on methodological studies: the what, when, how and why

Comparative efficacy and safety of Chinese medicine injections combined with capecitabine and oxaliplatin chemotherapies in treatment of colorectal cancer: A bayesian network meta-analysis

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