Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study

Cindolo, Luca; Spiess, Philippe E.; Bada, Maida; Chipollini, Juan; Nyírády, Péter; Chiodini, Paolo; Varga, Judith; Ditonno, Pasquale; Battaglia, Michele; Nunzio, Cosimo De; Tema, Giorgia; Veccia, Alessandro; Antonelli, Alessandro; Musi, Gennaro; Cobelli, Ottavio De; Conti, Andrea; Micali, Salvatore; Maestro, M. Álvarez; Olarte, J. Quesada; Diogenes, Erico; Lima, Marcos Venício Alves; Tracey, Andrew; Guruli, Georgi; Autorino, Riccardo; Sountoulides, Petros; Schips, Luigi

doi:10.1007/s00345-018-2549-3

Cited by 31 publications

(20 citation statements)

References 28 publications

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“…In contrast, only 1.9% chose a too superficial procedure, laser therapy (0.6%) or resurfacing of the glans 1.3%. This is in line with the findings of Bada et al and Cindolo et al who also showed that physicians are more likely to choose a too radical rather than a too superficial surgical approach, a problem that is aggravated in less experienced centers [11,15]. On a positive note, [90% of the physicians that participated in our survey stated that penile-sparing surgery is common practice in their department.…”

Section: Availability Of Penile-sparing Surgery Predicts Great Guidelsupporting

confidence: 91%

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Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS)

et al. 2020

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Introduction: Penile cancer (PeCa) is an orphan disease in European countries. The current guidelines are predominantly based on retrospective studies with a low level of evidence. In our study, we aimed to identify predictors for guideline-conform treatment and hypothesize that reference centers for PeCa and physicians' experience promote guideline compliance and therefore correct local tumor therapy. Methods: This study is part of the European PROspective Penile Cancer Study (E-PROPS), an international collaboration group evaluating therapeutic management for PeCa in Central Europe. For this module, a 14-item-survey was developed and sent to 681 urologists in 45 European centers. Three questions focused on Maximilian Pallauf and Marie C. Hempel both contributed equally to this work and should be considered shared first authors.

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Section: Availability Of Penile-sparing Surgery Predicts Great Guidelsupporting

confidence: 91%

“…Instead, the variance in compliance shows that there must be essential disease-specific differences. To our knowledge, only three retrospective studies exist so far comparing guideline recommendations and actual treatment regimens for local tumor treatment in PeCa [ 8 , 9 , 11 ]. Compliance ranged between 66 and 74.8%.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS)

et al. 2020

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“…Tissues from penile carcinomas were obtained during surgery according to local ethical regulations. Resected tissue specimens were processed for pathological diagnostic routine in agreement with institutional standards and diagnoses were made based on current WHO criteria (22,(41)(42)(43). The study was performed according to the Declaration of Helsinki and was approved by the local ethics committee of the University Hospital Essen (Ethik-Kommission, Medizinische Fakultät der Universität Duisburg-Essen, ethical approval number: 20-9508-BO).…”

Section: Patients and Proceduresmentioning

confidence: 99%

The Biomarker Potential of Caveolin-1 in Penile Cancer

et al. 2021

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Various types of human cancers were characterized by an altered expression of epithelial or stromal caveolin-1 (CAV1). However, the clinical significance of CAV1 expression in penile cancer remains largely unknown. Here the expression patterns of CAV1 were analyzed in a retrospective cohort (n=43) of penile squamous cell carcinomas (SCC). Upon penile cancer progression, significantly increased CAV1-levels were determined within the malignant epithelium, whereas within the tumor stroma, namely the fibroblastic tumor compartment harboring activated and/or cancer associated fibroblasts, CAV1 levels significantly decline. Concerning the clinicopathological significance of CAV1 expression in penile cancer as well as respective epithelial-stromal CAV1 distributions, high expression within the tumor cells as well as low expression of CAV1 within the stromal compartment were correlated with decreased overall survival of penile cancer patients. Herein, CAV1 expressions and distributions at advanced penile cancer stages were independent of the immunohistochemically proven tumor protein p53 status. In contrast, less differentiated p16-positive tumor epithelia (indicative for human papilloma virus infection) were characterized by significantly decreased CAV1 levels. Conclusively, we provide further and new evidence that the characteristic shift in stromal‐epithelial CAV1 being functionally relevant to tumor progression even occurs in penile SCC.

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“…Although inguinal lymphadenectomy is a life-saving procedure, there is a relevant fraction of patients that does not undergo this procedure. Even in specialized centers, 25% of patients are not treated according to guideline recommendations leading to a significantly higher risk of death compared to guideline-adherent treatment [4,5]. While the reasons for avoiding inguinal lymphadenectomy are unclear, the associated high morbidity is likely to contribute to this situation.…”

Section: Introductionmentioning

confidence: 99%

Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure

et al. 2020

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Purpose Inguinal lymphadenectomy in penile cancer is associated with a high rate of wound complications. The aim of this trial was to prospectively analyze the effect of an epidermal vacuum wound dressing on lymphorrhea, complications and reintervention in patients with inguinal lymphadenectomy for penile cancer. Patients and methods Prospective, multicenter, randomized, investigator-initiated study in two German university hospitals (2013-2017). Thirty-one patients with penile cancer and indication for bilateral inguinal lymph node dissection were included and randomized to conventional wound care on one side (CONV) versus epidermal vacuum wound dressing (VAC) on the other side. Results A smaller cumulative drainage fluid volume until day 14 (CDF) compared to contralateral side was observed in 15 patients (CONV) vs. 16 patients (VAC), with a median CDF 230 ml (CONV) vs. 415 ml (VAC) and a median maximum daily fluid volume (MDFV) of 80 ml (CONV) vs. 110 ml (VAC). Median time of indwelling drainage: 7 days (CONV) vs. 8 days (VAC). All grade surgery-related complications were seen in 74% patients (CONV) vs. 74% patients (VAC); grade 3 complications in 3 patients (CONV) vs. 6 patients (VAC). Prolonged hospital stay occurred in 32% patients (CONV) vs. 48% patients (VAC); median hospital stay was 11.5 days. Reintervention due to complications occurred in 45% patients (CONV) vs. 42% patients (VAC). Conclusions In this prospective, randomized trial we could not observe a significant difference between epidermal vacuum treatment and conventional wound care.

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Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study

Cited by 31 publications

References 28 publications

Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS)

Adherence to the EAU Guideline Recommendations for Local Tumor Treatment in Penile Cancer: Results of the European PROspective Penile Cancer Study Group Survey (E-PROPS)

The Biomarker Potential of Caveolin-1 in Penile Cancer

Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure

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