Adherence to Healthy and Sustainable Dietary Patterns and Long-Term Chronic Inflammation: Data from the EPIC-Potsdam Cohort

Koelman, L.; Herpich, C.; Norman, K.; Jannasch, F.; Börnhorst, C.; Schulze, M.B.; Aleksandrova, Krasimira

doi:10.1007/s12603-023-2010-1

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Indeed, to calculate adherence to EAT-Lancet score, we had to change the original version because not all components were available from the ORDET FFQ. To the best of our knowledge, only one manuscript evaluated the possible relationship between EAT-Lancet score and chronic low-grade inflammation [ 41 ]. In this study, the authors evaluated the association between change in adherence to the Mediterranean Diet Score and to the EAT-Lancet score and change in plasma CRP and chemerin levels in a subsample of the EPIC-Potsdam cohort who gave blood and dietary information more than once between 1994–1998 and 2013.…”

Section: Discussionmentioning

confidence: 99%

Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort

Quartiroli,

Roncallo,

Pala

et al. 2024

Nutrients

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Breast cancer (BC) is the most common cancer in women, with 2.3 million diagnoses in 2020. There is growing evidence that lifestyle factors, including dietary factors, particularly the complex interactions and synergies between different foods and nutrients (and not a single nutrient or food), may be associated with a higher risk of BC. The aim of this work was to evaluate how the Italian Mediterranean Index (IMI), the Greek Mediterranean Index, the DASH score, and the EAT-Lancet score can help lower the risk of BC, and analyze if chronic low-grade inflammation may be one of the possible mechanisms through which dietary patterns influence breast cancer risk. We evaluated the effect of adherence to these four dietary quality indices in the 9144 women of the ORDET cohort who completed a dietary questionnaire. The effect of adherence to dietary patterns on chronic inflammation biomarkers was evaluated on a subsample of 552 participants. Hazard ratios (HRs) with 95% confidence intervals (CIs) for BC risk in relation to the index score categories used were estimated using multivariable Cox models adjusted for potential confounders. Regression coefficients (β), with 95% CI for C-reactive protein (CRP), TNF-α, IL-6, leptin, and adiponectin levels in relation to adherence to dietary patterns were evaluated with the linear regression model adjusted for potential confounders. IMI was inversely associated with BC in all women (HR: 0.76, 95% CI: 0.60–0.97, P trend = 0.04), particularly among postmenopausal women (HR: 0.64, 95% CI: 0.42–0.98, P trend = 0.11). None of the other dietary patterns was associated with BC risk. Higher IMI and Greek Mediterranean Index scores were inversely associated with circulating CRP (β: −0.10, 95% CI: −0.18, −0.02, and β: −0.13, 95% CI: −0.21, −0.04). The higher score of the EAT-Lancet Index was instead associated with a higher concentration of circulating levels of CRP (β: 0.10, 95% CI: 0.02, 0.18). In conclusion, these results suggest that adherence to a typical Italian Mediterranean diet protects against BC development, especially among postmenopausal women, possibly through modulation of chronic low-grade inflammation.

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Section: Discussionmentioning

confidence: 99%

Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort

Quartiroli,

Roncallo,

Pala

et al. 2024

Nutrients

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Prevention by Heat Stimulation of Metabolic Syndrome Progression Based upon the Underlying Molecular Mechanism

Nagai,

Kaji

2024

Metabolic Syndrome - Lifestyle and Biological Risk Factors

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Metabolic syndrome (MS) is a pathological condition that causes high blood pressure, abnormal glucose metabolism, and lipid metabolism based on visceral fat accumulation. Insulin resistance and atherosclerosis caused by chronic inflammation of visceral adipose tissue are fundamental pathologies of lifestyle-related diseases. It is well known that diet and exercise are important in preventing these diseases. However, exercise is limited in people with various locomotive disorders. In recent years, the use of heat therapy to treat insulin resistance has attracted attention. Many researchers are interested in strengthening the skeletal muscle functions as a metabolic organ. We are verifying the thermal effect of skeletal muscles on underlying mechanism of MS progression such as chronic inflammation, cell death and heat shock protein 70 family (HSP70). This chapter reviews recent reports on whether hyperthermia may safely contribute to the prevention of MS and its progression to type 2 diabetes and atherosclerosis. It was thought that the chaperone function of HSP70 could be used to influence inflammatory cytokines and contribute to the prevention of insulin resistance and atherosclerosis. Thermal effects may be useful, especially when physical activity is limited. Safe and effective interventions to prevent MS and its progression require further research.

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Adherence to Healthy and Sustainable Dietary Patterns and Long-Term Chronic Inflammation: Data from the EPIC-Potsdam Cohort

Cited by 2 publications

References 52 publications

Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort

Adherence to Diet Quality Indices and Breast Cancer Risk in the Italian ORDET Cohort

Prevention by Heat Stimulation of Metabolic Syndrome Progression Based upon the Underlying Molecular Mechanism

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