Adherence to Immunosuppression Medications among Heart Transplant Recipients: Challenges, Opportunities, and Potential Role of Digital Approaches in the COVID-19 Era

Hussain, Tasmeen; Nassetta, Keira; Badawy, Sherif M.

doi:10.3390/jcdd8060068

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Some other cohort studies towards solid organ transplant recipients showed a similar conclusion: almost no patients completely discontinued the use immunosuppressants, but other nonadherence behaviors, such as delayed doses or skipping a dose, were very commonly seen in COVID-19 era. 8,9 We can find similar phenomena in rheumatic diseases population. According to a survey conducted in America in April 2020, 48% of even not obtain the drugs they need totally.…”

Section: Discussionsupporting

confidence: 59%

Poor Compliance Causes Acute Rejection in Kidney Transplant Recipients During COVID-19 Pandemic: 2 Cases Report

Ma¹,

An²,

Lu³

et al. 2022

PPA

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The COVID-19 pandemic has lasted for more than one year, which caused much trouble to the health management of kidney transplant recipients. Numerous patients cancelled their review appointment or even lost connection with doctors because of the great pressure medical system undergoing, strict travel restrictions, and the worries about COVID-19 infection risk. Herein, we introduce two kidney transplant recipients, a 33-year-old man and a 32-year-old man, who did not take the immunosuppressant drugs and did not go back to the hospital to do the renal function examination as the doctor's request. When they paid their first return visit several months after the pandemic outbreak, they were both diagnosed with acute rejection and admitted to the hospital. After receiving pulse steroid therapy, they were in remission but failed to reverse the rejection. The level of serum creatinine did not recover to the one before pandemic outbreak. These cases suggest that it is necessary to ensure that kidney transplant recipients follow the doctor's advice to take drugs and follow-up regularly to examine their renal function over pandemic period. Additionally, typical pulse steroid therapy may not that effective toward these patients.

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Section: Discussionsupporting

confidence: 59%

Poor Compliance Causes Acute Rejection in Kidney Transplant Recipients During COVID-19 Pandemic: 2 Cases Report

Ma¹,

An²,

Lu³

et al. 2022

PPA

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“…This aspect should be considered a fundamental component of telemedicine practices for this patient cohort. Additionally, some researchers have directed their attention to the utilization of mobile health (m-Health) to bolster post-transplantation self-management for patients and enhance medication adherence [99,100]. The mHeart study [101] investigated the use of the mHeart mobile application and demonstrated a notable rise in drug adherence compared to standard care, along with a notable improvement in patients' perceived ease and understanding of medication regimens.…”

Section: Telehealth In Left Ventricular Assist Device and Heart-trans...mentioning

confidence: 99%

Heart Failure Management through Telehealth: Expanding Care and Connecting Hearts

Tedeschi,

Palazzini,

Trimarchi

et al. 2024

JCM

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Heart failure (HF) is a leading cause of morbidity worldwide, imposing a significant burden on deaths, hospitalizations, and health costs. Anticipating patients’ deterioration is a cornerstone of HF treatment: preventing congestion and end organ damage while titrating HF therapies is the aim of the majority of clinical trials. Anyway, real-life medicine struggles with resource optimization, often reducing the chances of providing a patient-tailored follow-up. Telehealth holds the potential to drive substantial qualitative improvement in clinical practice through the development of patient-centered care, facilitating resource optimization, leading to decreased outpatient visits, hospitalizations, and lengths of hospital stays. Different technologies are rising to offer the best possible care to many subsets of patients, facing any stage of HF, and challenging extreme scenarios such as heart transplantation and ventricular assist devices. This article aims to thoroughly examine the potential advantages and obstacles presented by both existing and emerging telehealth technologies, including artificial intelligence.

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“…Aziz et al [5] note that the effect of this shift in the care of transplant patients is currently unknown but may affect short and long-term patient outcomes. Similar to medical professionals’ changing duties, in the initial stages of the pandemic, many adult and pediatric patients may have experienced a disruption to their work or school schedules [6 ▪▪ ]. Many schools transitioned to virtual learning and some businesses transitioned to a ‘work-from-home’ model.…”

Section: Severe Acute Respiratory Syndrome Corona Virus Disease Of 20...mentioning

confidence: 99%

Adherence in transplantation

Kuntz

Engel

2022

Current Opinion in Organ Transplantation

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Purpose of reviewAdequately managing a complex medical regimen is paramount to the success of organ transplants. When patients stray from their prescribed medical regimen posttransplant, graft rejection, and death can occur. Predictors of adherence have been studied for many years, and various factors have been identified as contributing to adequate or poor adherence. Both demographic and personal characteristics have been associated with adherence behavior. However, recent developments, such as the COVID-19 pandemic, increased use of mobile health interventions, and use of medical biomarkers have affected the way adherence is measured and applied.Recent findingsThe COVID-19 pandemic affected patients’ comfort with accessing outpatient care and created a wider use of telehealth services. Measurement of adherence through serum lab levels continues to be reviewed as a potential objective assessment of adherence. Psychosocial factors continue to be identified as major contributors to nonadherence.SummaryAdherence to antirejection medication, lab work, appointments, and exercise and dietary instructions remains critical to the health of the transplant patient. It is critical that providers involved in the selection process and posttransplant treatment of these patients remain well informed of potential new factors affecting adherence.

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Adherence to Immunosuppression Medications among Heart Transplant Recipients: Challenges, Opportunities, and Potential Role of Digital Approaches in the COVID-19 Era

Cited by 5 publications

References 33 publications

Poor Compliance Causes Acute Rejection in Kidney Transplant Recipients During COVID-19 Pandemic: 2 Cases Report

Poor Compliance Causes Acute Rejection in Kidney Transplant Recipients During COVID-19 Pandemic: 2 Cases Report

Heart Failure Management through Telehealth: Expanding Care and Connecting Hearts

Adherence in transplantation

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