Adherence to levetiracetam for management of epilepsy: Assessment with electronic monitors

Kolli, Sree S; Snyder, Stephanie; Cardwell, Leah A.; Cline, Abigail; Unrue, Emily L; Feldman, Steven R.; O’Donovan, Cormac A.

doi:10.1016/j.seizure.2021.10.008

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…In a study in Taiwan conducted in over 13,000 patients over a period of one year, 74% of patients on CBZ, 71% on phenytoin (PHT), 67% on VPA, 56% on oxcarbazepine (OXC), 78% on gabapentin (GBP), 75% on topiramate (TPM) and 54% on lamotrigine (LTG) did not comply with medical recommendations within one year of the inclusion in treatment. This study also showed that compared with patients treated with CBZ, a significantly lower risk of non-compliance was found among patients treated with OXC (adjusted hazard ratio [HR], 0.78; 95% CI: 0.74–0.83), VPA (0.88; 0.85–0.92), LTG (0.72; 0.65–0.81) and TPM (0.90; 0.82–0.98), while patients taking PHT had a significantly higher risk of non-compliance [ 75 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Epilepsy’s Medical Recommendations

Jopowicz,

Piechal,

Bronisz

et al. 2024

Brain Sciences

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The primary problem in the treatment of epilepsy is poor seizure control. Several studies have shown that non-adherence to doctors’ recommendations regarding drug dosage, time of drug administration as well as lifestyle modifications are the most frequent causes of the persistence or reoccurrence of seizures, other than cases of misdiagnosis and poor drug selection. The aim of this study was to assess the prevalence of non-compliance with medical recommendations, both in relation to medicine dosage, regularity of administration and lifestyle, and also to determine the factors affecting patients with diagnosed epilepsy. This study was carried out on a total of 169 patients diagnosed with epilepsy who were under the care of an outpatient neurology clinic. The assessment of compliance was performed using the Patient Rating of Compliance Scale (PRCS), Clinician Rating Scale (CRS) and authors’ scale. Depending on the scale used, varying degrees of non-compliance were noted. They were as follows—65.3% on the authors’ scale, 10% on the PRCS and 9% on the CRS. The following factors influenced compliance with doctors’ recommendations: type of epilepsy, consumption of alcoholic beverages, frequency of follow-up visits to the neurology clinic, type of pharmacotherapy and number of medicines taken.

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Section: Discussionmentioning

confidence: 99%

Adherence to Epilepsy’s Medical Recommendations

Jopowicz,

Piechal,

Bronisz

et al. 2024

Brain Sciences

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Medication compliance of children with epilepsy: a cross-sectional survey

Wang,

Zhang,

Wang

et al. 2023

Ital J Pediatr

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Background Good medication compliance is very important for the prognosis of children with epilepsy. We aimed to evaluate the status and influencing factors of medication compliance in children with epilepsy and to provide insights to the clinical nursing care of children with epilepsy. Methods We selected epileptic children admitted to Children’s Hospital of Nanjing Medical University from February 1, 2022 to August 31, 2022. Self-designed questionnaire and medication compliance scale were used to evaluate the characteristics and medication compliance of children with epilepsy. Pearson correlation analysis and multivariate logistic regression were used to analyze the influencing factors of medication compliance. Results A total of 156 children with epilepsy were included, the incidence of poor compliance in children with epilepsy was 37.18%. Pearson correlation analysis indicated that age(r = 0.622), courses of epilepsy(r = 0.553), parental education level(r = 0.506), monthly household income(r = 0.652) and number of drugs taken(r = 0.577) were correlated with the compliance(all P<0.05). Logistic regression analyses indicated that age ≤ 6 y(OR = 2.104, 95%CI: 1.712 ~ 2.527), courses of epilepsy ≤ 3 years(OR = 2.661, 95%CI: 2.089 ~ 2.941), low parental education level(OR = 1.977, 95%CI: 1.314 ~ 2.351), monthly household income ≤ 5000 RMB(OR = 2.812, 95%CI: 2.194 ~ 3.181), number of drugs taken ≥ 3(OR = 3.025, 95%CI: 2.336 ~ 3.475) were the influencing factors of medication compliance in children with epilepsy(all P<0.05). Conclusions The medication compliance of children with epilepsy needs to be improved, and the medication compliance of children is affected by age, courses of epilepsy, parental education level, monthly household income and number of drugs taken. Clinical medical personnel take targeted nursing measures against these factors to improve the medication compliance of children with epilepsy.

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Adherence to levetiracetam for management of epilepsy: Assessment with electronic monitors

Cited by 2 publications

References 16 publications

Adherence to Epilepsy’s Medical Recommendations

Adherence to Epilepsy’s Medical Recommendations

Medication compliance of children with epilepsy: a cross-sectional survey

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