Adherence to Oxidative Balance Scores is Associated with a Reduced Risk of Breast Cancer; A Case-Control Study

Sohouli, Mohammad Hassan; Baniasadi, Mansoureh; Hernández‐Ruiz, Ángela; Melekoğlu, Ebru; Zendehdel, Mona; Soto-Méndez, María José; Akbari, Atieh; Zarrati, Mitra

doi:10.1080/01635581.2022.2102658

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…To our knowledge, this is the first study to investigate the OBS as a protective factor against NAFLD. However, several studies have investigated the potential beneficial effects of this index on other chronic diseases such as metabolic syndrome 36 , diabetes 37 , cancer 38 , kidney 39 , 40 , and cardiovascular diseases 40 which seemed to have a similar mechanism to the risk of NAFLD. In addition, the relationship between this index with the reduction of oxidative stress and systemic inflammation has been investigated as a major risk factor in NAFLD 41 .…”

Section: Discussionmentioning

confidence: 99%

Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study

Sohouli

Rohani

Hosseinzadeh

et al. 2023

Sci Rep

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Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxidative balance scores (OBS) and the risk of NAFLD. 552 healthy and 340 patients adult over the age of 18 with NAFLD participated in this case–control research. A validated 168-item quantitative food frequency questionnaire (FFQ) and indicators of physical activity, obesity, and smoking status were used to assess OBS score. The connection between OBS and NAFLD was discovered using binary logistic regression. The mean (± SD) age and (body mass index) BMI of the study population was 40.22 ± 9.79 years and 29.06 ± 3.92 kg/m2, respectively. The mean ± SD of OBS was 41.48 ± 5.23. After adjustment for potential confounders, higher scores of adherence to the OBS conferred a protection for the presence of NAFLD (odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15–0.49; P for trend < 0.001). The findings of the present study indicate an approximately 80% reduction in the odds of developing NAFLD with higher OBS adherence in the overall population. However, prospective studies are needed to further investigate this association.

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Section: Discussionmentioning

confidence: 99%

Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study

Sohouli

Rohani

Hosseinzadeh

et al. 2023

Sci Rep

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“…And OBS has proven to be an effective tool for evaluating oxidative stress status (23). Previous studies have found that high OBS levels were associated with reduced risk of several diseases, including osteoporosis, metabolic syndrome, type-2 diabetes, and breast cancer (24)(25)(26)(27). To the beast of our knowledge, however, the association of OBS with hearing loss was unclear in adults.…”

Section: Introductionmentioning

confidence: 99%

Association between oxidative balance score and hearing loss: a cross-sectional study from the NHANES database

Zhou,

Han

2024

Front. Nutr.

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AimThe oxidative balance score (OBS), a composite score of dietary nutrients and lifestyles, reflects an individual’s oxidative and antioxidant status. Evidence showed that oxidative stress levels were related to hearing loss. The relationship between OBS and hearing loss remains unclear. This study was to explore the association between OBS and hearing loss in adults.MethodsIn this cross-sectional study, data of participants aged 20–69 years who received hearing tests were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2011–2012, 2015–2016). Hearing loss was defined as hearing threshold >25 dB in either ear. The OBS was composed of 16 dietary nutrients and 4 lifestyles. The covariates were screened using the backward stepwise regression analysis. The association of OBS and hearing loss was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Subgroups of age, gender, occupational noise exposure, recreational noise exposure, firearm noise exposure, and veteran status were further evaluated the associations. The importance ranking of OBS components was analyzed by the weighted random forest model.ResultsOf the total 3,557 adults, 338 (9.5%) suffered from hearing loss. High OBS levels were associated with lower odds of hearing loss (OR = 0.58, 95%CI: 0.41–0.82), after adjusting age, gender, race, hypertension, tinnitus, recreational noise exposure, and occupational noise exposure. Similar results were discovered in individuals aged50-59 years old (OR = 0.47, 95%CI: 0.24–0.93), aged 60–69 years old (OR = 0.31, 95%CI: 0.16–0.61), with female (OR = 0.44, 95%CI: 0.20–0.96), without occupational noise exposure (OR = 0.31, 95%CI: 0.16–0.62), recreational noise exposure (OR = 0.48, 95%CI: 0.30–0.76), firearm noise exposure (OR = 0.38, 95%CI: 0.19–0.77), and veteran status (OR = 0.57, 95%CI: 0.39–0.82). In OBS components, vitamin B12, total fat and physical activity were important for hearing loss.ConclusionElevated OBS may be associated with hearing health in adults. Appropriate vitamin B12 supplementation, reduction of total fat intake, and increased physical activity may be beneficial to the prevention of hearing loss.

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“…The Oxidative Balance Score (OBS) is an integrative measure designed to assess the cumulative oxidative stress status within the body, encompassing 20 distinct dietary and lifestyle components. Emerging evidence postulates that OBS could be a potent biomarker for forecasting the likelihood of diseases rooted in oxidative stress, such as hypertension, diabetes, and breast cancer [10,11]. Notably, research focusing on postmenopausal women has revealed an inverse correlation between higher OBS and the reduced incidence of OP [12].…”

Section: Introductionmentioning

confidence: 99%

Association Between Oxidative Balance Score and Osteoporosis in U.S. Adults: The National Health and Nutrition Examination Survey (NHANES) 2005-2020

Wen,

Zhang,

et al. 2024

Preprint

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Background Osteoporosis (OP) is a prevalent disease that increases the risk of fractures and affects quality of life. Although there are many factors that contribute to OP, there are fewer studies on the relationship between oxidative balance score (OBS) and OP. Methods We conducted a cross-sectional analysis to examine the association of OBS with the prevalence of OP among U.S. adults using National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2020. A final sample of 18,837 participants was included after exclusions. OBS was calculated from dietary and lifestyle data, and OP status was determined using bone mineral density (BMD) measurements. Logistic regression models and restricted cubic spline (RCS) analyses were used to explore the association between OBS and OP after adjusting for confounders. Results Our study demonstrated an inverse association between OBS and the prevalence of OP. For every unit increase in OBS, there was a 3% reduction in the odds of OP after adjustment (OR = 0.97, 95%CI: 0.96–0.99). Higher dietary OBS was associated with reduced OP risk, while an improved lifestyle OBS corresponded to higher OP incidence (P < 0.05). A linear inverse relationship between continuous OBS values and OP risk was observed, and subgroup analyses revealed that females experienced more pronounced protection as OBS increased. Conclusion The present study suggests an inverse relationship between OBS and OP in adults, with dietary OBS inversely linked to OP prevalence and lifestyle OBS positively associated. In addition, the association between OBS and OP differed between sexes.

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Adherence to Oxidative Balance Scores is Associated with a Reduced Risk of Breast Cancer; A Case-Control Study

Cited by 7 publications

References 48 publications

Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study

Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case–control study

Association between oxidative balance score and hearing loss: a cross-sectional study from the NHANES database

Association Between Oxidative Balance Score and Osteoporosis in U.S. Adults: The National Health and Nutrition Examination Survey (NHANES) 2005-2020

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