Adherence to Screening Guidelines for Hepatitis C Among HIV-Positive Patients

Jonckheere, Sylvie; Vincent, Anne; Belkhir, Leïla; Wilmes, Dunja; Vandercam, Bernard; Yombi, Jean Cyr

doi:10.1089/apc.2013.0096

Cited by 10 publications

(7 citation statements)

References 9 publications

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“…1 However, even when HIV providers are aware of guidelines calling for vaccination and screening for co-morbid conditions, compliance with these guidelines may be low. 21 HIV providers and researchers should investigate ways to improve the outpatient quality of care. The Patient Centered Medical Home, a team-based model of care that emphasizes personalized, accessible, high-quality, and comprehensive care over time and across healthcare settings, 22 has been shown to improve the delivery of preventative care services.…”

Section: Discussionmentioning

confidence: 99%

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Assessing the Overall Quality of Health Care in Persons Living with HIV in an Urban Environment

Keller

Yehia

Momplaisir

et al. 2014

AIDS Patient Care and STDs

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Ensuring high quality primary care for people living with HIV (PLWH) is important. We studied factors associated with meeting Health Resources and Services Administration-identified HIV performance measures, among a population-based sample of 376 PLWH in care at 24 Philadelphia clinics. Quality of care was assessed by a patient-level composite of 15 performance measures, focusing on HIV-specific care, vaccinations, and comorbid condition screening. Adjusted incidence rate ratios (IRR) demonstrated relationships between patient and clinic factors and the performance measures score. The mean number of measures met was 8.52. Older age groups met more measures than 18-to 29-year-olds (age 40-49: adjusted IRR: 1.19, 95% CI: 1.05-1.35; age ‡ 50: adjusted IRR: 1.19, 95% CI: 1.03-1.35). Higher CD4 counts were associated with meeting more measures compared to CD4 < 200 cells/lL (CD4 350-499 cells/lL: adjusted IRR: 1.14, 95% CI: 1.02-1.28; ‡ 500 cells/ lL: adjusted IRR: 1.12, 95% CI: 1.01-1.26). PLWH attending clinics that provide adherence counseling or case management met more measures (adjusted IRR: 1.12, 95% CI: 1.04-1.21; adjusted IRR: 1.08, 95% CI: 1.02-1.14; respectively) than those attending clinics without these services. Limitations include potentially poor performance measure documentation and equal treatment of measures. Future work should focus on improving compliance with performance measures.

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Section: Discussionmentioning

confidence: 99%

“…We found that older age groups (ages 40-49 and ‡ 50) met more performance measures than the youngest age group (ages [18][19][20][21][22][23][24][25][26][27][28][29]. Providers may be more cognizant of the need for certain tests in adults ‡ 40 years of age (i.e., lipid screening).…”

Section: Discussionmentioning

confidence: 99%

Assessing the Overall Quality of Health Care in Persons Living with HIV in an Urban Environment

Keller

Yehia

Momplaisir

et al. 2014

AIDS Patient Care and STDs

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“…11 Despite this, evidence suggests that people living with HIV are not routinely screened for HCV infection. 12 …”

Section: Introductionmentioning

confidence: 99%

Comparison of Hepatitis C Virus RNA and antibody detection in dried blood spots and plasma specimens

Dokubo

Evans

Winkelman³

et al. 2014

Journal of Clinical Virology

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Background Current diagnostic tests for Hepatitis C Virus (HCV) involve phlebotomy and serologic testing for HCV antibodies (anti-HCV) and RNA, which are not always feasible. Dried blood spots (DBS) present a minimally invasive sampling method and are suitable for sample collection, storage and testing. Objectives To assess the utility of DBS in HCV detection, we evaluated the sensitivity and specificity of DBS for anti-HCV and HCV RNA detection compared to plasma specimens. Study design This cross-sectional validation study was conducted in the context of an existing prospective study of HCV in young injection drug users. Blood samples were collected by venipuncture into serum separator tubes (SST) and via finger stick onto Whatman 903® protein-saver cards. Plasma samples and eluates from the DBS were tested for anti-HCV using either a third generation enzyme-linked or chemiluminescent immunoassay (IA), and HCV RNA using discriminatory HCV transcription-mediated amplification assay (dHCV TMA). DBS results were compared to their corresponding plasma sample results. Results 148 participants were tested for anti-HCV and 132 participants were tested for HCV RNA. For anti-HCV, the sensitivity of DBS was 70%, specificity was 100%, positive predictive value (PPV) was 100%, negative predictive value (NPV) was 76% and Kappa was 0.69. For HCV RNA, the sensitivity of DBS was 90%, specificity was 100%, PPV was 100%, NPV was 94% and Kappa was 0.92. Conclusions DBS are sensitive and very specific in detecting anti-HCV and HCV RNA, demonstrate good correlation with plasma results, and have potential to facilitate diagnosis of HCV infection.

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“…Fourth, these findings may underrepresent the magnitude of the issue, as adherence to screening guidelines is imperfect, and more patients may be affected. 10 Finally, BCTT involves the use of pegylated interferon and ribavirin, and these medications can have their own drug-drug interactions, and this could upwardly drive up the number of CSDDI. This was not the case in this study.…”

mentioning

confidence: 99%

Predicting the Probability of Experiencing Clinically Significant Drug–Drug Interactions Involving Boceprevir-Containing Hepatitis C Therapy Among Patients Coinfected with Hepatitis C and HIV

Patel

Veve²,

Nasiri³

et al. 2014

AIDS Patient Care and STDs

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Adherence to Screening Guidelines for Hepatitis C Among HIV-Positive Patients

Cited by 10 publications

References 9 publications

Assessing the Overall Quality of Health Care in Persons Living with HIV in an Urban Environment

Assessing the Overall Quality of Health Care in Persons Living with HIV in an Urban Environment

Comparison of Hepatitis C Virus RNA and antibody detection in dried blood spots and plasma specimens

Predicting the Probability of Experiencing Clinically Significant Drug–Drug Interactions Involving Boceprevir-Containing Hepatitis C Therapy Among Patients Coinfected with Hepatitis C and HIV

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