High blood pressure (BP) and hypertension are major global risk factors for cardiovascular disease 1 and require a holistic approach for optimal management with both nonpharmacological and pharmacological interventions. National US and international recommendations [2][3][4] for the management of high BP endorse lifestyle changes, including weight loss for the overweight or obese, regular physical activity, adherence to a healthy nutrition plan such as the Dietary Approaches to Stop Hypertension (DASH) diet, 5 and reducing dietary sodium intake. 6 However, which single nutrient or dietary pattern has the most profound effect on BP is a matter of ongoing research. 7 In this issue of the journal, Allison et al. 8 report on the effects a low fat, high fruit, vegetable, and grain dietary intervention on incident hypertension and longitudinal BP changes in 48,835 postmenopausal women who participated in the Women's Health Initiative (WHI) Dietary Modification Trial. The US National Institutes of Health established the $625 million dollar WHI in 1991 to address the most common causes of death, disability and impaired quality of life in postmenopausal women. 9 The study included 161,808 women aged 50-79 years from 40 nationwide clinical centers; 68,132 in clinical trials and 93,676 in observational studies with the goal of reducing coronary heart disease, breast and colorectal cancer, and osteoporotic fractures. The Dietary Modification Trial was the largest of the randomized clinical trials and participants were followed for 8-12 years. Women in the dietary intervention group decreased their fat intake to 20% of total daily calories, increased fruit and vegetable consumption to five or more servings per day and increased grain intake to greater than or equal to six servings per day, monitored their food intake and attended regular nutrition group meetings. The control group maintained their usual eating habits, received standard information on nutrition guidelines, kept a food diary and filled out health questionnaires. The study found no significant differences in the rates of heart disease, stroke, or cancer between the two groups. [10][11][12] Allison et al. 8 now report post hoc analyses of the effect of the dietary intervention on incident hypertension and BP trajectories in order to shed light over the lack of difference in cardiovascular disease, as previously encouraged by others. 13 Hypertension was defined as selfreport of treated hypertension collected semi-annually or BP ≥140/90 mm Hg at one of the annual follow-up visits. After a mean follow-up of 8.3 years, and among those who did not have hypertension at baseline (n = 31,146), there were 16,174 incident hypertension cases. The intervention group had 4% lower overall risk of developing hypertension compared to the control group. Although the risk of hypertension was lower in the intervention group in the first few years, the hazard ratio became greater than 1 after year 5. Similarly, while the low fat intervention resulted in lower average systolic BP at...