Adherence to treatment in patients with Behçet's disease

Khabbazi, Alireza; Shayan, Farid Karkon; Ghojazadeh, Morteza; Kavandi, Hadiseh; Hajialiloo, Mehrzad; Manesh, Kamal Esalat; Kolahi, Sousan

doi:10.1111/1756-185x.13109

Cited by 17 publications

(11 citation statements)

References 57 publications

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“…In the current study, 77% of participants did not attend higher education, and this is in line with other studies that reported 87% and 76.4% of patients do not have higher education (6,33). Nevertheless, it contradicts other studies that reported most of the responder patients (44.9%-78.10%) had university or college education (4,5,31). Marital status was as follows: married for most of the patients (74%), single for 19% of the patients, and divorced or widowed for 7% of BD patients.…”

Section: Discussionsupporting

confidence: 86%

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

Mirzamohammadi,

Salehi,

Hosseini

et al. 2024

Preprint

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Background Behcet’s disease (BD) is a chronic inflammatory condition mostly identified by recurrent oral aphthous ulcers and several systemic symptoms. The etiology of BD is not clear; however, some studies suggest some risk factors, such as low socioeconomic status (SES) and poor living conditions. This study aimed to determine the relationship between SES and the first manifestation of BD, the occurrence of symptoms, and the recurrence of ocular involvement. Methods In this cross-sectional study, clinical and laboratory data and socioeconomic features of 200 patients diagnosed with BD were recorded. Patients were classified into three quantiles of SES using principal component analysis (PCA) and regression model. Fisher's exact test and the chi-square test were used to measure differences among SES groups. Results The mean age of patients was 44.9 ± 12.6 years. Most of the participants (90.5%) resided in cities. Considering BD manifestations, ocular involvement recurrence mostly occurred in patients with low SES (n = 19, 42.22%) and less often with moderate SES (n = 9, 20.00%) compared to high SES (n = 17, 37.78%) (p = 0.033). Cataract involvement was more common in the low SES group (n = 31, 50.82%) compared to the moderate (n = 24, 39.34%) and high SES (n = 12, 20%) groups (p = 0.01). There were no other statistically significant differences regarding BD organ involvements or laboratory data among different SES groups. Conclusion The present evidence concludes that SES may be an important contributing factor in the course of BD. Low SES may deteriorate relapses of ocular involvement and cataracts. Whereas, moderate SES has a protective effect on relapse, and high SES protects against cataracts.

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Section: Discussionsupporting

confidence: 86%

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

Mirzamohammadi,

Salehi,

Hosseini

et al. 2024

Preprint

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“…Considering that there are few data on treatment adherence in BS (10,11), this study aimed to further explore low-or non-adherence in BS. In particular, an ad-hoc questionnaire was co-designed with patients affected by BS and launched across the Italian community of BS patients.…”

Section: Introductionmentioning

confidence: 99%

Adherence to treatment in Behçet's syndrome: a multi-faceted issue

Pirri

Marinello

Lorenzoni

et al. 2021

Clinical and Experimental Rheumatology

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Objective. The aim of this study is to explore the adherence to treatment in patients with Behçet's syndrome (BS), to identify the diverse adherence profiles and their correlations. Methods. A cross-sectional study among adult BS patients was conducted administering an ad-hoc questionnaire to BS patients with the aim of investigating several dimensions related to BS management, including attitudes towards treatment. A Latent Class Analysis (LCA) was performed to identify adherence profiles and associated characteristics were identified using logistic regression analysis. Results. A total of 207 patients answered the survey and 180 of them declared to take medication for BS, thus representing the study population. More than a third of the respondents have declared that they have skipped treatments before and autonomously modified (reduced or increased) the dosage of the treatment without medical consultation. LCA analysis allowed the identification of two distinct profiles, one more stick with recommended medication and the other less adherent to treatment. The less-adherent BS patient profile seems to be related with being in the third decade of life, being diagnosed with BS for more than 5 years and perceiving greater psychological impact of the disease. Conclusion.Addressing adherence in BS is not only related to measuring treatment adherence and identifying the barriers and the limitations; in fact, it should also encompass a wider approach that includes the awareness, the socio-psychological impact of the dis ease as well as patient education.

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“…The results of the PRISMA flowchart are shown in Figure 1 Self-reported measurements, such as in interviews, self-reported questionnaires and focus groups in which patients provided information about medication they were taking, emerged as the most practical and common approaches to measure the adherence rate in CTDs (28,29,34,35,39,40,42,43,45,46,48). In particular, seven studies developed a tailored self-reported questionnaire to assess medication adherence.…”

Section: N Resultsmentioning

confidence: 99%

A systematic literature review of existing tools used to assess medication adherence in connective tissue diseases: the state of the art for the future development of co-designed measurement tools

et al. 2021

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Lack of medication adherence is frequent in chronic connective tissue diseases and is associated with poorer health outcomes, low quality of life and economic loss. This research is based on a systematic literature search and aims to identify the surveys and tools used for the assessment of medication adherence in patients with connective tissue diseases (CTDs) and in particular the tools co-designed with patients. A systematic literature review was performed in PubMed and Embase databases searching for studies concerning the application of surveys or tools designed for medication adherence assessment. A specific analysis was also performed to identify which of these existing tools were developed in co-design with patients affected by CTDs. 1958 references were identified, and 31 studies were finally included. Systemic lupus erythematosus was the most investigated disease, followed by the Behçet’s disease. The tools used to assess adherence in CTDs were, in most cases, valid and useful. However, the results showed a certain degree of heterogeneity among the studies and the medication adherence assessment and measurement tools adopted, which were mostly based on selfreported questionnaire. No co-designed tools with patients were found. Low- and non-adherence were explored in some CTDs with valid and useful tools, while other CTDs still need to be assessed. Therefore, more efforts should be made to better understand the specific reasons for the low- and non-adherence in CTDs patients.

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Adherence to treatment in patients with Behçet's disease

Abstract: Non-adherence is common in patients with BD. Male sex, low income, low knowledge about the disease, being employed and being on treatment with NSAIDs are the main risk factors for non-adherence.

Cited by 17 publications

References 57 publications

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

The Relationship Between Socioeconomic Status and Behcet’s Disease Manifestations

Adherence to treatment in Behçet's syndrome: a multi-faceted issue

A systematic literature review of existing tools used to assess medication adherence in connective tissue diseases: the state of the art for the future development of co-designed measurement tools

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