The up-to-date scientific evidence suggests that adequate levels of physical activity provide essential health benefits for children and adolescents and help to maintain a healthy body weight. In this sense, children and adolescents should at least accumulate 60 min of moderate-to-vigorous physical activity in a daily basis to achieve these benefits and be considered active. Likewise, some lifestyle-related elements may interact with each other in an antagonistic or synergistic way to modify physical activity status. Thus, a better understanding of how meeting physical activity recommendations influences these potentially modifiable lifestyle factors (obesity-related parameters, physical fitness, dietary habits, or sedentary behaviour) would significantly reinforce the importance of complying with those recommendations from a health perspective and support the establishment of strategies for the promotion of diminishing the lower trends of physical activity among the young population. This study seeks to verify the association of meeting physical activity international recommendations with obesity-related parameters, global physical fitness, screen time, and Mediterranean diet in Spanish schoolchildren aged 8 to 13. A cross-sectional study was performed including 250 schoolchildren (41.2% girls) aged 8–13 (9.7 ± 1.2) from six primary schools in the Region of Murcia (Spain). Results: A higher proportion of children who complying with physical activity recommendations shows normal weight, no abdominal obesity, and low adiposity in comparison to other with different obesity-related parameters categories. Higher values in global physical fitness score were found in those who meet the physical activity international recommendations in both sexes. These higher values were also shown for adherence to the Mediterranean diet in both sexes; not being so in the case of screen time. Notwithstanding, none of these mean differences were statistically significant. To conclude, the proportion of schoolchildren meeting the physical activity recommendations in our study is low. A higher proportion of children who meet with physical activity recommendations present normal weight, no abdominal obesity and low adiposity in comparison to other obesity-related parameters categories in both sexes. Likewise, those considered as active children seem to have higher global physical fitness score and adherence to the Mediterranean diet than children who do not meet the recommendations.