Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Rutherford, Emily J.; Hill, Arnold D.; Hopkins, Ann M.

doi:10.3390/cells7050043

Cited by 24 publications

(18 citation statements)

References 140 publications

(143 reference statements)

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“…VIM expression is upregulated in epithelial tumors of uterine corpus origin, but not epithelial tumors of ovarian origin 52 . ICAM-1 is expressed in migratory EC 53 , and is linked to increased peritoneal adhesion in endometriosis 54 . VIM and ICAM-1 may serve as markers of ARID1A-negative tumors of endometrial origin.…”

Section: Discussionmentioning

confidence: 99%

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

et al. 2019

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ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when combined with PI3K activation. Sorted mutant epithelial cells display gene expression and promoter chromatin signatures associated with epithelial-to-mesenchymal transition (EMT). We further show that ARID1A is bound to promoters with open chromatin, but ARID1A loss leads to increased promoter chromatin accessibility and the expression of EMT genes. PI3K activation partially rescues the mesenchymal phenotypes driven by ARID1A loss through antagonism of ARID1A target gene expression, resulting in partial EMT and invasion. We propose that ARID1A normally maintains endometrial epithelial cell identity by repressing mesenchymal cell fates, and that coexistent ARID1A and PI3K mutations promote epithelial transdifferentiation and collective invasion. Broadly, our findings support a role for collective epithelial invasion in the spread of abnormal endometrial tissue.

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Section: Discussionmentioning

confidence: 99%

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

et al. 2019

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“…Dysregulated cell-cell and cell-matrix adhesion has a role in the development of endometriosis [138]. Endometrial cells derived from proliferative and secretory endometrial fragments, as well as menstrual endometrial fragments, are able to adhere to where the peritoneal mesothelium is damaged and the basement membrane or the interstitial ECM are exposed.…”

Section: Behind the Origins Of Endometriosismentioning

confidence: 99%

“…Adhesion of retrograde menstrual endometrium to the peritoneum is mediated by adhesion molecules that modulate cell-matrix and cell-cell attachments and are expressed by endometrial cells, including cadherins, integrins, proteoglycans such as syndecans, laminin-binding proteins, the immunoglobulin superfamily, and CD44. Integrins, syndecans, cadherins, CD44, and CD44’s binding partner hyaluronan have been studied extensively in endometrium and in endometriosis [138].…”

Section: Behind the Origins Of Endometriosismentioning

confidence: 99%

The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

Laganà

Garzon

Götte

et al. 2019

IJMS

356

265

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The etiopathogenesis of endometriosis is a multifactorial process resulting in a heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still far from being fully elucidated, the current review aims to offer a comprehensive summary of the available evidence. We performed a narrative review synthesizing the findings of the English literature retrieved from computerized databases from inception to June 2019, using the Medical Subject Headings (MeSH) unique ID term “Endometriosis” (ID:D004715) with “Etiology” (ID:Q000209), “Immunology” (ID:Q000276), “Genetics” (ID:D005823) and “Epigenesis, Genetic” (ID:D044127). Endometriosis may origin from Müllerian or non-Müllerian stem cells including those from the endometrial basal layer, Müllerian remnants, bone marrow, or the peritoneum. The innate ability of endometrial stem cells to regenerate cyclically seems to play a key role, as well as the dysregulated hormonal pathways. The presence of such cells in the peritoneal cavity and what leads to the development of endometriosis is a complex process with a large number of interconnected factors, potentially both inherited and acquired. Genetic predisposition is complex and related to the combined action of several genes with limited influence. The epigenetic mechanisms control many of the processes involved in the immunologic, immunohistochemical, histological, and biological aberrations that characterize the eutopic and ectopic endometrium in affected patients. However, what triggers such alterations is not clear and may be both genetically and epigenetically inherited, or it may be acquired by the particular combination of several elements such as the persistent peritoneal menstrual reflux as well as exogenous factors. The heterogeneity of endometriosis and the different contexts in which it develops suggest that a single etiopathogenetic model is not sufficient to explain its complex pathobiology.

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“…Menstrual effluent and morphological alterations can easily damage the intact mesothelium—a protective barrier against the implantation; the own adhesion site can also be created to implant regurgitated endometrial cells [ 46 , 47 , 48 ]. The adhesion of endometrium fragments to the peritoneum in women with endometriosis is enhanced by the overproduction of cellular adhesion molecules that facilitate intercellular binding and cellular attachments with the extracellular matrix; including CD44 transmembrane glycoprotein, cell adhesion molecules (CAM) such as integrins, cadherins, selectins, the immunoglobulin superfamily (Ig-CAM), and transmembrane-anchored proteoglycans like syndecans [ 49 , 50 ].…”

Section: Molecular Targets In Endometriosis Dietary Managementmentioning

confidence: 99%

Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives

2021

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Endometriosis represents an often painful, estrogen-dependent gynecological disorder, defined by the existence of endometrial glands and stroma exterior to the uterine cavity. The disease provides a wide range of symptoms and affects women’s quality of life and reproductive functions. Despite research efforts and extensive investigations, this disease’s pathogenesis and molecular basis remain unclear. Conventional endometriosis treatment implies surgical resection, hormonal therapies, and treatment with nonsteroidal anti-inflammatory drugs, but their efficacy is currently limited due to many side effects. Therefore, exploring complementary and alternative therapy strategies, minimizing the current treatments’ adverse effects, is needed. Plants are sources of bioactive compounds that demonstrate broad-spectrum health-promoting effects and interact with molecular targets associated with endometriosis, such as cell proliferation, apoptosis, invasiveness, inflammation, oxidative stress, and angiogenesis. Anti-endometriotic properties are exhibited mainly by polyphenols, which can exert a potent phytoestrogen effect, modulating estrogen activity. The available evidence derived from preclinical research and several clinical studies indicates that natural biologically active compounds represent promising candidates for developing novel strategies in endometriosis management. The purpose of this review is to provide a comprehensive overview of polyphenols and their properties valuable for natural treatment strategy by interacting with different cellular and molecular targets involved in endometriosis progression.

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Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Cited by 24 publications

References 140 publications

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives

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