Adhesion Molecule Expression and Adhesion Properties of Murine Intestinal Intraepithelial Lymphocyte Hybridomas

Ni, Jian; Hollander, Daniel; Sydora, Beate C.; Panwala, Chetan

doi:10.1006/cimm.1995.1155

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Discussion1

Cd44 Can Recognize Various Css and Ch To Mediate Cell Adhesion1

Homotypic Interaction Of Epcam In Mucosal Defense Against In1

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Cited by 8 publications

(3 citation statements)

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“…ICAM-1 is a counter receptor of CD11a, and Abs against ICAM-1 and CD11a partially block the binding of the IEL line to epithelial cells. 27,28 It is thus speculated that IEL affect epithelial cells and upregulate ICAM-1, resulting in the facilitation of IEL binding to epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Alteration of intestinal epithelial function by intraepithelial lymphocyte homing

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Alteration of intestinal epithelial function by intraepithelial lymphocyte homing

et al. 2005

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“…As shown in Fig. 1A, mouse lymphoma BW5147 cells, which express a constitutively active form of CD44 [19] but no detectable levels of L-selectin, E-selectin, P-selectin, or ␤2 or ␣4 integrins [20], showed significant binding to wells coated with 1 mg/ml of CH, CS A, CS B, CS C, CS D, CS E, or HA. The significant cell binding still occurred when CS was diluted to 10 g/ml, and was temperature-insensitive (data not shown).…”

Section: Cd44 Can Recognize Various Css and Ch To Mediate Cell Adhesionmentioning

confidence: 90%

CD44–chondroitin sulfate interactions mediate leukocyte rolling under physiological flow conditions

et al. 2004

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“…49 Such a direct interaction of intestinal epithelia cells and intraepithelial lymphocytes provides an immunological barrier against mucosal infection. Recently, EpCAM was found to mediate homotypic interactions between intraepithelial lymphocytes and intestinal epithelia cells.…”

Section: Homotypic Interaction Of Epcam In Mucosal Defense Against Inmentioning

confidence: 99%

Epithelial Cell Adhesion Molecule

Trzpis

McLaughlin

Leij

et al. 2007

The American Journal of Pathology

487

224

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The epithelial cell adhesion molecule (EpCAM , CD326) is a glycoprotein of ϳ40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studies, EpCAM was proposed to be a cell-cell adhesion molecule. However, recent insights revealed a more versatile role for EpCAM that is not limited only to cell adhesion but includes diverse processes such as signaling, cell migration, proliferation, and differentiation. Cell surface expression of EpCAM may actually prevent cell-cell adhesion. Here, we provide a comprehensive review of the current knowledge on EpCAM biology in relation to other cell adhesion molecules. We discuss the implications of the newly identified functions of EpCAM in view of its prognostic relevance in carcinoma , inflammatory pathophysiology , and tissue development and regeneration as well as its role in normal epithelial homeostasis.

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Adhesion Molecule Expression and Adhesion Properties of Murine Intestinal Intraepithelial Lymphocyte Hybridomas

Cited by 8 publications

References 0 publications

Alteration of intestinal epithelial function by intraepithelial lymphocyte homing

Alteration of intestinal epithelial function by intraepithelial lymphocyte homing

CD44–chondroitin sulfate interactions mediate leukocyte rolling under physiological flow conditions

Epithelial Cell Adhesion Molecule

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