Adhesion Molecules as Predictors of Nasal Polyposis Recurrence

Abstract

Adhesion molecules may relate to nasal polyp prognosis and recurrence rates.

Can a panel of clinical, laboratory, and pathological variables pinpoint patients with sinonasal polyposis at higher risk of recurrence after surgery?

“…Further attempts should be made to go beyond clinical and conventional pathological considerations and investigate the biological mechanisms behind CRSwNP. Since molecular changes are primarily responsible for the biological behavior of inflammation, new biomarkers involved in angiogenesis [20], proliferation, adhesion molecules [24], and tissue remodeling have to be tested by immunohistochemistry and/or quantitative real-time polymerase chain reaction to see if they can help in predicting the course of CRSwNP.…”

Nasal cytology: Methodology with application to clinical practice and research

“…Considering that nasal polyps recur in approximately one‐third of patients after surgical treatment, CRSwNP phenotypes would be helpful in depicting patients in whom we might expect recurrence and in predicting clinical outcome after surgery. Significant efforts have been made to individuate some specific clinical (comorbid asthma), serological (high peripheral eosinophil count and histological predictors of recurrence, such as high eosinophilic infiltrates in polyps and adhesion molecules (mucin 1 and CD86 stromal expression): Wormald and colleagues recommended that the extent of mucosal inflammatory load, especially tissue eosinophils, should be considered as the most important indicator for functional or radical surgical approach . Similarly, Uhliarova et al demonstrated that in patients with CRSwNP and elevated levels of eosinophils in the nasal lavage fluid and in nasal tissue are significantly more prone to recurrence and therefore require higher rate of revision FESS (Functional Endoscopic Sinus Surgery).…”

Predictive Significance of Tissue Eosinophilia for Nasal Polyp Recurrence in the Chinese Population

“…Factors such as symptom severity, preoperative computed tomography (CT) score, polyp size, comorbid asthma, allergic status, peripheral eosinophilia, adhesion molecules expression, and mucosal histologic characteristics shed light on the association with polyp recurrence in previous studies. [11][12][13][14][15][16][17] Among these parameters, mucosal eosinophilia is a more important predictor than other predictors. 4,13 However, mucosal eosinophilia exhibits significant geographic and ethnic differences.…”