Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters

Kamel, Azza M.; El-Sharkawy, Nahla; Osman, Randa A.; El-Fattah, Eman K. Abd; Elnoshokaty, Essam H.; El-Hamid, Thoraya Abd; Kandeel, Eman Z.

doi:10.1016/j.jnci.2016.01.003

Cited by 12 publications

(12 citation statements)

References 30 publications

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“…In contrast, Ibrahim et al showed that CD38 expression is associated with hepatomegaly and aggressive clinical stages (9). Also, the signi cant association between CD38 expression and splenomegaly and intermediate and high-risk disease was reported by some other studies (17,18). In contrast to some reports in the literature, we found that the percentage of CD38 expression has no signi cant correlation with CBC results.…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to some reports in the literature, we found that the percentage of CD38 expression has no signi cant correlation with CBC results. Studies have reported that CD38 expression has a positive correlation with WBC and lymphocyte count (18,19) and a negative correlation with Hb concentration and platelet count (9,15,17,19). Although there was not any signi cant correlation between CD38 expression and NLR (r = 0.307, p = 0.073), the higher percentage of this marker was associated with higher NLR.…”

Section: Discussionmentioning

confidence: 93%

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Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Bagheri

Vosoughi

Hosseinzadeh

et al. 2020

Preprint

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Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters.Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p< 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, inverse ‎association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, group3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has an inverse correlation with neutrophil/lymphocyte ratio (r = -0.340, p = 0.046). Given that there is an inverse ‎association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 93%

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Bagheri

Vosoughi

Hosseinzadeh

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…There was no signi cant association between CD38 expression and each clinical parameter (lymphadenopathy, splenomegaly, Rai staging, modi ed Rai staging, and Binet staging systems). This nding is consistent with that of Abdelgader et al and Kamel et al studies, which reported no signi cant association between CD38 expression and clinical parameters (15,16). In contrast, Ibrahim et al showed that CD38 expression is associated with hepatomegaly and aggressive clinical stages (9).…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Bagheri

Vosoughi

Hosseinzadeh

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers expression with complete blood cell count (CBC) values and clinical parameters. Results: Peripheral blood samples were collected from 35 new CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, negative association with Rai staging, modified Rai staging, Binet staging systems (all p< 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, negative association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, as group3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has a negative correlation with neutrophil/lymphocyte ratio (r = -0.340, p = 0.046). Given that there is a negative association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.

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“…There was no significant association between CD38 expression and each clinical parameter (lymphadenopathy, splenomegaly, Rai staging, modified Rai staging, and Binet staging systems). This finding is consistent with that of Abdelgader et al and Kamel et al studies, which reported no significant association between CD38 expression and clinical parameters [16,17]. In contrast, Ibrahim et al showed that CD38 expression is associated with hepatomegaly and aggressive clinical stages [9].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

et al. 2020

View full text Add to dashboard Cite

Objective: Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters. Results: Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p < 0.001 in both parameters), and splenomegaly (p = 0.001 and 0.007, respectively). The platelet/lymphocyte ratio (PLR) had a significant, inverse association with Rai staging (p = 0.014), modified Rai staging (p = 0.024), Binet staging systems (p = 0.027), and splenomegaly (p = 0.033). However, CD38, CD25, and double-positive CD56/CD117 expression, group 3 of innate lymphocyte cells (ILC3s), had no significant association with clinical parameters. In regression analysis, that ILC3s has an inverse correlation with neutrophil/lymphocyte ratio (r = −0.340, p = 0.046). Given that there is an inverse association between PLR and advanced clinical stages, it seems that PLR may have prognostic value in CLL.

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Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters

Abstract: The level of different adhesion molecules expression in CLL is apparently reflected on the potential migratory behavior of the leukemic cells to different organs.

Cited by 12 publications

References 30 publications

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Evaluation of Immunophenotypic Markers and Clinico-Hematological Profile in Chronic Lymphocytic Leukemia: Implications for Prognosis

Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis

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