Adhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea

El-Solh, Ali; Mador, M. Jeffery; Sikka, Pawan; Dhillon, Rajwinder S.; Amsterdam, Daniel; Grant, Brydon J. B.

doi:10.1378/chest.121.5.1541

Cited by 174 publications

(115 citation statements)

References 27 publications

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“…A close positive relationship has been noted between elevated levels of VCAM-1 and the apneahypopnea index [2]. A similar relationship exists between ICAM-1 and the oxygen desaturation index.…”

supporting

confidence: 58%

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Emerging new biomarkers in obstructive sleep apnea

Kapoor

2012

Sleep Breath

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supporting

confidence: 58%

“…Similarly, higher P-selectin levels are an indicator of more severe OSA. Some studies have shown a similar association between L-selectin and OSA while others have shown no association [2,4].…”

mentioning

confidence: 96%

Emerging new biomarkers in obstructive sleep apnea

Kapoor

2012

Sleep Breath

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“…In addition, Korzh et al [42] stated that the levels of VCAM-1, E-selectin, P-selectin, CRP, WBC count were higher in OSA patients than in control subjects [42]. Similarly, several studies found direct significant relationship between adhesive molecules and severity of OSA measured by ODI and AHI [43][44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Jiffri

2017

GHOA

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Background: Obstructive sleep apnea (OSA) is recognized as a major public health issue, as it has a significant influence on the incidence and prognosis of cardiovascular diseases.Objective: This study was designed to detect the association between OSA and biomarkers of inflammation and adhesion molecules that may be useful in medical screening for OSA.Methods: Sixty-five volunteer subjects were interviewed. However, only 64 of them met eligibility criteria. Their age ranged from 28-53 years and their body mass index (BMI) ranged from 30 to 40 kg/m 2 . All participants who were enrolled into two groups according to value of Apnea-hypopnea index (AHI) into two groups: Group (A) consisted of 27 obese subjects with AHI ≥5 events/hour and group (B) consisted of 38 obese subjects with AHI <5 events/hour.

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“…28 On the other hand, elevated plasma levels of various adhesion molecules and increased expression of adhesion molecules on leukocytes and their adherence to endothelial cells have been reported and are thought to have a role in endothelial cell dysfunction, formation of atherosclerosis, and clot formation. 29 Studies on OSA treated with CPAP have demonstrated improved insulin resistance, 30 a reversal of the inflammatory response as evidenced by a decrease in serum endothelin-1, 25 an increase in serum nitric oxide levels, 26 and a decrease in C-reactive protein and interleukin-6 31 , thus further supporting a relationship between OSA and the metabolic syndrome. Although these studies suggest a relationship between OSA and atherosclerosis formation, there is presently no definite evidence to prove this.…”

Section: Pathophysiology Of Cvdmentioning

confidence: 97%

Obstructive sleep apnea and cardiovascular effects-a review

Hossain

Pasha

2009

Univ. Heart J.

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Obstructive sleep apnea (OSA) is a highly prevalent disease, affecting 4% of men and 2% of women. 1 Obstructive sleep apnea (OSA) is a common and frequently under diagnosed condition characterized by recurrent episodes of partial or complete obstruction of the upper airway during sleep, decrease in oxygen saturation and daytime somnolence. 2 Significant clinical consequences of OSA cover a wide spectrum including neurocognitive dysfunction 3 , cardiovascular disease (CVD), 4,5 metabolic dysfunction, 6,7 respiratory failure, and cor pulmonale. 8 OSA patients frequently have several risk factors for CVD development, such as obesity, hypertension, and diabetes. [4][5][6] These risk factors are entangled in such a way that it is difficult to isolate the relative contribution of OSA to cardiovascular risk. OSA is independently associated with several CVD, including hypertension, ischemic heart disease, atrial fibrillation, cerebrovascular disease, and heart failure, 4,5, though the magnitude of OSA effects, as compared to other risk factors for cardiovascular disease, is not well established. Pathophysiology of CVD:The pathophysiology of possible deleterious cardiovascular effects of OSA is thought to involve two major components: first, the mechanical effect of apneas on intrathoracic pressures and heart function and second intermittent hypoxemia resulting in sympathetic overdrive and endothelial cell dysfunction (figure1). 9 Although there is no definitive evidence to determine whether OSA directly causes cardiovascular disease, the available data do suggest an increased risk of having car E-mail : drmosharraf_hossain@yahoo.com AbstractObstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing, affecting 5-15% of the population. It is characterized by intermittent episodes of partial or complete obstruction of the upper airway during sleep that disrupts normal ventilation and sleep architecture, and is typically associated with excessive daytime sleepiness, snoring, and witnessed apneas. Patients with obstructive sleep apnea present risk to the general public safety by causing 8-fold increase in vehicle accidents, and they may themselves also suffer from the physiologic consequences of OSA; these include hypertension, coronary artery disease, stroke, congestive heart failure, pulmonary hypertension, and cardiac arrhythmias. Of these possible cardiovascular consequences, the association between OSA and hypertension has been found to be the most convincing. Although the exact mechanism has not been understood, there is some evidence that OSA is associated with frequent apneas causing mechanical effects on intrathoracic pressure, cardiac function, and intermittent hypoxemia, which may in turn cause endothelial dysfunction and increase in sympathetic drive. Therapy with continuous positive airway pressure has been demonstrated to improve cardiopulmonary hemodynamics in patients with OSA and may reverse the endothelial cell dysfunction. Limited availability of diagnostic measures and unawaren...

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Adhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea

Cited by 174 publications

References 27 publications

Emerging new biomarkers in obstructive sleep apnea

Emerging new biomarkers in obstructive sleep apnea

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Obstructive sleep apnea and cardiovascular effects-a review

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