1993
DOI: 10.1038/361082a0
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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

Abstract: Langerhans cells (LC) are the principal accessory cells present in epidermis. Because LC have limited capacity for self-renewal, epidermis is continually repopulated by as-yet uncharacterized bone marrow-derived LC progenitors. In addition, although LC persist in epidermis for extended periods, LC are induced to migrate from skin to regional lymph nodes after antigen exposure. To begin to elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte (KC) interactions. Here we report that fr… Show more

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Cited by 446 publications
(308 citation statements)
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“…These cytokines may mobilize LC from the epidermis by abolishing the E-cadherinmediated adhesion between LC and KC [71,72]. E-cadherin expression was down-regulated in a subpopulation of LC activated by in situ exposure to contact allergens, and by cutaneous administration of proinflammatory cytokines, including TNF-␣, IL-1␣, and IL-1␤.…”
Section: Proinflammatory Cytokines Stimulate Lc Migrationmentioning
confidence: 98%
“…These cytokines may mobilize LC from the epidermis by abolishing the E-cadherinmediated adhesion between LC and KC [71,72]. E-cadherin expression was down-regulated in a subpopulation of LC activated by in situ exposure to contact allergens, and by cutaneous administration of proinflammatory cytokines, including TNF-␣, IL-1␣, and IL-1␤.…”
Section: Proinflammatory Cytokines Stimulate Lc Migrationmentioning
confidence: 98%
“…They express the common DC marker CD1a but can be distinguished from other DC by the presence of intracellular Birbeck granules, containing the C-type lectin Langerin (CD207) (1), and by their expression of E-cadherin, enabling tight interaction with epithelial cells (2). LC are long-lived in comparison to other DC subtypes, and recent studies have highlighted the ability of LCprecursors to proliferate in situ (3).…”
Section: Angerhans Cells (Lc)mentioning
confidence: 99%
“…Epidermal cells were prepared as described previously with slight modifications (27). Briefly, ears were split into dorsal and ventral halves and incubated in HBSS containing 0.5% trypsin and 1 mM EDTA for 45 min at 37°C.…”
Section: Preparation Of Cell Suspensions For Flow Cytometrymentioning
confidence: 99%