Adhesion of meticillin-resistant <i>Staphylococcus aureus</i> to DACC-coated dressings

Rönner, Anna-Clara; Curtin, Justin; Karami, Nahid; Rönner, Ulf

doi:10.12968/jowc.2014.23.10.484

Cited by 21 publications

(34 citation statements)

References 14 publications

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“…Microbes, including fungi, are irreversibly bound through hydrophobic interactions to the DACC coating on the dressing surface. Recent in vitro evidence indicates that DACC enhances binding of methicillin‐resistant Staphylococcus aureus and biofilms.…”

Section: Discussionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

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Background Disease of the pilonidal sinus is a common condition that affects mainly young adults. Options for management include excision of the sinus tracts, leaving the wound open to heal by secondary intention. The aim of this study was to compare wound healing with dialkylcarbamoyl chloride (DACC)‐coated dressings versus alginate dressings. Methods This multicentre trial randomized consecutive patients undergoing surgery for pilonidal disease to postoperative wound care with either DACC‐coated or alginate dressings. The primary outcome was the proportion of wounds healed after 75 days. Secondary outcomes were the local status of wounds during the healing process, the quality assessment of the dressings by the patient, and the time needed to return to usual activities. Results A total of 246 patients were included: 120 in the DACC‐coated group and 126 in the alginate group. In per‐protocol analysis, there were significantly more patients with completely healed wounds after 75 days in the DACC group than in the alginate group: 78 of 103 (75·7 per cent) versus 58 of 97 (60 per cent) respectively (odds ratio 2·55, 95 per cent c.i. 1·12 to 5·92; P = 0·023). During follow‐up, wounds with alginate dressings had more fibrin than those with DACC‐coated dressings, but the difference was not significant (P = 0·079). There was no difference between the two arms in patients' assessment of the dressings. Conclusion The number of wounds completely healed at 75 days was significantly higher for DACC‐coated compared with alginate dressings. However, the preplanned, clinically significant improvement in healing of 20 per cent was not reached. Registration number: NCT02011802 ( https://clinicaltrials.gov/).

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Section: Discussionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

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“…In addition, Sorbact was covered using a standard dressing. 7 After 48 hours of using Sorbact, the wound edge and the surrounding wound tissue became softer and lighter in colour. The granulation tissue was more homogeneously distributed and less flaky (Figure 3).…”

Section: Case Reportmentioning

confidence: 99%

“…Sorbact was applied as a wound contact layer to remove wound pathogens and avoid chemical agents, protecting the tissue from further wound colonisation. In addition, Sorbact was covered using a standard dressing . After 48 hours of using Sorbact, the wound edge and the surrounding wound tissue became softer and lighter in colour.…”

Section: Introductionmentioning

confidence: 99%

Treating a non‐healing postoperative sternal wound in a woman with type 2 diabetes mellitus: A case report

Castiello

Ghizzardi

Dellafiore

et al. 2019

International Wound Journal

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One of the leading causes of impaired chronic wound healing is diabetes mellitus because it involves many factors that influence the physiopathology of tissue healing. Therefore, it is strategic to analyse clinical cases of this population. We presented a clinical case report of a 51‐year‐old female with type 2 diabetes mellitus, presenting a non‐healing sternal wound after open heart surgery. Appropriate dressing and assessment contributed to the healing of the sternal wound in 5 weeks.

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“…One technology not included in reviews to date is dialkylcarbamoylchloride (DACC), a fatty acid derivative that has been shown in vitro to bind to a number of pathogenic organisms, including Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus (MRSA) . This can be applied to dressings to irreversibly bind bacteria, thus removing them from the wound bed .…”

Section: Introductionmentioning

confidence: 99%

A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride‐coated dressings versus standard care for the primary prevention of surgical site infection

Totty

Hitchman

Cai

et al. 2019

International Wound Journal

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A surgical site infection (SSI) may occur in up to 30% of procedures and results in significant morbidity and mortality. We aimed to assess the feasibility of conducting a randomised controlled trial (RCT) examining the use of dialkylcarbamoylchloride (DACC)-impregnated dressings, which bind bacteria at the wound bed, in the prevention of SSI in primarily closed incisional wounds. This pilot RCT recruited patients undergoing clean or clean-contaminated vascular surgery. Participants were randomised intraoperatively on a 1:1 basis to either a DACC-coated dressing or a control dressing. Outcomes were divided into feasibility and clinical outcomes. The primary clinical outcome was SSI at 30 days (assessed using Centers for Disease Control criteria and Additional treatment, Serous discharge, Erythema, Purulent exudate, Separation of the deep tissues, Isolation of bacteria and duration of inpatient Stay scoring methods). This study recruited 144 patients in 12 months at a median rate of 10 per month. Eligibility was 73% and recruitment 60%. At 30 days, there was a 36.9% relative risk reduction in the DACC-coated arm (16.22% versus 25.71%, odds ratio 0.559, P = 0.161). The number needed to treat was 11 patients. A large-scale RCT is both achievable and desirable given the relative risk reduction shown in this study. Further work is needed to improve the study protocol and involve more centres in a full-scale RCT.

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Adhesion of meticillin-resistant Staphylococcus aureus to DACC-coated dressings

Cited by 21 publications

References 14 publications

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

Treating a non‐healing postoperative sternal wound in a woman with type 2 diabetes mellitus: A case report

A pilot feasibility randomised clinical trial comparing dialkylcarbamoylchloride‐coated dressings versus standard care for the primary prevention of surgical site infection

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