“…Cell membrane is generally to serve as a permeability barrier, which prevents the entry of toxic compounds but allows the influx of nutrient molecules (Lai et al, 2013). Small molecules move across the cell membrane through directly diffuse driven by their concentration gradients, integral membrane protein pumps or ion channels, whereas nanoscale biomolecules are conventionally pass through the cell membrane by endocytosis (Zhao et al, 2011).…”