Adhesion of tissue glues to different biological substrates

Abstract

Tissue adhesives are attractive materials with potential to replace the use of sutures and staples in the repair of the injured tissues. The research field of tissue adhesives is dynamically growing, and different methods and tissue models are employed to evaluate the adhesive properties of newly developed materials. It is thus difficult to directly compare the properties of materials developed by researchers from different groups. Moreover, the extrapolation of results obtained using different tissue models to the targeted human tissues is often not possible. Therefore, the purpose of the current study was to evaluate the adhesive properties of the three different tissues adhesives: the clinically used Dermabond W and fibrin glues, and the recently developed isocyanate-terminated three-armed adhesive block copolymers. Different biological substrates were used to assess their adhesion strengths: bovine Achilles tendon, meniscus tissue and skeletal muscle, chamois leather, and collagen films. Comparisons of the adhesive properties of the glues with these substrates were made. The obtained results were analyzed in terms of the chemistry and the adhesion mechanisms of the glues, and the composition and properties of the substrates like their hydrophilicity and surface morphology. We conclude that standardized procedures and models should be developed to allow direct comparison between the different (developed) tissue adhesives and to enable extrapolation of the results towards the targeted human tissues.

Mechanistic Insights into Silk Fibroin’s Adhesive Properties via Chemical Functionalization of Serine Side Chains

“…A Discovery HR2 hybrid rheometer equipped with a DHR Film/Fiber Tension Accessory (TA Instruments, New Castle, DE) was used for single lap shear testing of all samples. 32 Natural sheep skin chamois leather (Amazon, Seattle, WA) was washed with a mild detergent followed by five deionized water washes then allowed to dry for several days. The leather was then cut into individual 10 × 25 mm strips for testing.…”

Adhesive Cements That Bond Soft Tissue Ex Vivo

“…Soft tissue adhesives are an attractive alternative to sutures and staples, with a number of comparative advantages. Tissue adhesives are easy to apply, cause minimal trauma, they allow tissues to heal without needing to remove the adhesive at a later point, produce lower rates of infection [6,7] and less morbidity compared to staples and sutures, reduce operating time, and can improve cosmetic outcomes (i.e., less scaring) [1,8,9]. Many different adhesives have been explored for closing [10,11,12], or reattaching, injured soft tissues, including adhesives based on acrylate “superglue” [13], fibrin [14], polysaccharide [15,16], protein [1,17,18], or organic acid [19,20].…”

Biobased polyurethanes for biomedical applications

“…Biobased –NCO terminated PU adhesives [ 282 , 283 ] have consequently been developed and can be cured in the presence of water and/or a chain extender, thus be used for several types of tissues. Of course, the adhesion strength strongly depend on the tissue substrate [ 284 ]. However, PU adhesives major drawback is the relative long curing time [ 285 , 286 ].…”