Adhesive lift method for patterning arbitrary-shaped thin ion-selective films in micro/nanofluidic device

Seo, Myungjin; Park, Sung Min; Ryu, Jihye; Kim, Sung Jae

doi:10.1039/d2lc00185c

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…As examples of the introduction of functionalized auxiliary micro/nanostructures to avoid dendrite formation, anodic aluminum oxides (AAOs) and metal–organic frameworks (MOFs) have been introduced on the surface of Li metal as functional separators. ,− Furthermore, in our recent study, we experimentally and numerically revealed that a negatively charged porous structure with submicrometer pore size as Zn metal hosting layers enhanced the electrokinetic Zn 2+ ion transport in Zn aqueous battery and effectively prevented the metal dendrite formation . Not only to batteries but also to shock electrodialysis and microfluidic biochips for sample separation and preconcentration utilizing ICP, these functionalized auxiliary microstructures such as dielectric porous structures, − pillars, or microfin networks , have been systematically applied to control ion transport around ion-selective interfaces. These structures switch the mechanism of ion transport from the EOI governed regime to a more stabilized form of the SC governed regime and/or EOF governed regime to resolve the troublesome problem of flow instability, leading to stable performance.…”

Section: Introductionmentioning

confidence: 93%

Differential Impact of Surface Conduction and Electroosmotic Flow on Ion Transport Enhancement by Microscale Auxiliary Structures

Park,

Cho,

Park

et al. 2024

Langmuir

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Our research investigates the impact of auxiliary structures on ion transport in electrochemical systems such as batteries and microscale desalination units, whose importance for sustainable development has increased dramatically in recent decades. The electrochemical systems typically feature ion-selective surfaces, such as electrodes and ion exchange membranes, where ion depletion can cause performance issues including metal dendrite formation and flow instability. Recent research has shown that auxiliary structures in these electrochemical systems can enhance ion transfer near ion-selective surfaces, thereby resolving the instability problem and improving the energy conversion efficiency of the system. Our study leverages recent advancements in nanoscale electrokinetics to model these auxiliary structures as pillar arrays near an ion exchange membrane in a microchannel. We examine how these structures enhance ion transports relative to the characteristic length scale of microchannel depth and pillars' proximity to the ion-selective surface. Results show that the effect of the pillars varies significantly with their placement. Specifically, in deeper microchannels, where electrokinetic convection is stronger, the closer the auxiliary structure is to the ion-selective membrane, the better the ion transfer. However, in the thinner microchannel, the proximity of the auxiliary structure to the ion selective membrane has a less significant correlation with the ion transfer. Therefore, this finding highlights the importance of spatial arrangement of the auxiliary structures in improving the performance of electrochemical devices. Conclusively, this study can help to better understand energy conversion systems such as fuel cells, salinity gradient power generation systems, and electrochemical desalination systems, where auxiliary structures can be used in the vicinity of ion-selective surfaces. Especially, our fundamental electrokinetic study provides an effective means for designing the efficient electrochemical platforms utilizing micro/nanofluidics.

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Section: Introductionmentioning

confidence: 93%

Differential Impact of Surface Conduction and Electroosmotic Flow on Ion Transport Enhancement by Microscale Auxiliary Structures

Park,

Cho,

Park

et al. 2024

Langmuir

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“…Recently, an electrokinetic process called ion concentration polarization (ICP) as a target amplification mechanism is adopted rather than the techniques mentioned above. Within the nanostructure, only the counter ion can pass through it because of the overlapped electric double layer. , This causes an ionic imbalance around the nanostructure, which leads to various physicochemical phenomena such as the formation of an ion depletion zone, a locally amplified electric field in the ion depletion zone, , nonequilibrium space charge, − electroconvective instability, − and overlimiting currents, − etc. Among those unique phenomena, the highly efficient preconcentration of charged species in the electrolyte loaded in the micro/nanofluidic platform (Figure a) can be achieved by this ICP phenomenon .…”

Section: Introductionmentioning

confidence: 99%

dCas9-Mediated PCR-Free Detection of Oncogenic Mutation by Nonequilibrium Nanoelectrokinetic Selective Preconcentration

et al. 2023

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Cutting-edge nanoelectrokinetic technology in this work provides a breakthrough for the present clinical demands of molecular diagnosis to detect a trace amount of oncogenic mutation of DNA in a short time without an erroneous PCR procedure. In this work, we combined the sequence-specific labeling scheme of CRISPR/dCas9 and ion concentration polarization (ICP) mechanism to separately preconcentrate target DNA molecules for rapid detection. Using the mobility shift caused by dCas9’s specific binding to the mutant, the mutated DNA and normal DNA were distinguished in the microchip. Based on this technique, we successfully demonstrated the dCas9-mediated 1-min detection of single base substitution (SBS) in EGFR DNA, a carcinogenesis indicator. Moreover, the presence/absence of target DNA was identified at a glance like a commercial pregnancy test kit (two lines for positive and one line for negative) by the distinct preconcentration mechanisms of ICP, even at the 0.1% concentration of the target mutant.

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Enhancement of Overlimiting Current in a Three-Dimensional Hierarchical Micro/Nanofluidic System by Non-uniform Compartmentalization

Park,

Kim,

Kang

et al. 2024

BioChip J

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Overlimiting current (OLC) is a non-linear current response that occurs related to an ion concentration polarization (ICP) phenomenon in micro/nanofluidic systems and holds great importance since it represents the rate of selective ion transportation through perm-selective structure. For last two decades, numerous studies of OLC have been reported about understanding the fundamentals of nanoelectrokinetics and enhancing ion transportation through perm-selective membranes. Recent study reported that the alignment of non-uniform microspace near the perm-selective membranes in two-dimensional micro/nanofluidic systems can significantly enhance OLC, i.e., overlimiting conductance (σOLC). This is attributed to recirculation flow induced by combination of unbalanced electroosmosis and induced pressure driven flow among non-uniform microspaces. However, 2D micro/nanofluidic systems have limited practicality due to their small volume and low throughput. Herein, we tested the OLC enhancement using 3D-printed hierarchical micro/nanofluidic systems with respect to the non-uniformity of microspaces. The 3D microspaces were fabricated as a mesh structure using a conventional 3D printer. By comparing current–voltage measurement with each type of mesh, we experimentally confirmed the generation of recirculation flow among non-uniform meshes and ionic current enhancement in 3D hierarchical micro/nanofluidic system. Also, we further investigated the enhancement of overlimiting conductance depending on the mesh pattern. Furthermore, we validated that this effect of microscale non-uniform compartmentalization, both increasing surface area and aligning non-uniform spaces, appears not only at low molar concentration but at high molar concentrations. This demonstration can offer a strategy to design optimal electrochemical systems where a perm-selective ion transportation is crucial.

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Adhesive lift method for patterning arbitrary-shaped thin ion-selective films in micro/nanofluidic device

Abstract: Micro/nanofluidic platforms with nanoporous films have been utilized as research tools for studying electrokinetic phenomena occurred not only in macro-scale systems such as electro-desalination but also in micro-scale systems such...

Cited by 7 publications

References 47 publications

Differential Impact of Surface Conduction and Electroosmotic Flow on Ion Transport Enhancement by Microscale Auxiliary Structures

Differential Impact of Surface Conduction and Electroosmotic Flow on Ion Transport Enhancement by Microscale Auxiliary Structures

dCas9-Mediated PCR-Free Detection of Oncogenic Mutation by Nonequilibrium Nanoelectrokinetic Selective Preconcentration

Enhancement of Overlimiting Current in a Three-Dimensional Hierarchical Micro/Nanofluidic System by Non-uniform Compartmentalization

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