Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease

Koeck, Emily S.; Iordanskaia, Tatiana; Sevilla, Samantha; Ferrante, Sarah C.; Hubal, Monica J.; Freishtat, Robert J.; Nadler, Evan P.

doi:10.1016/j.jss.2014.06.050

Cited by 164 publications

(120 citation statements)

References 47 publications

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“…EVs could be successfully purified by differential centrifugation of conditioned medium obtained from cultured adipose tissue explants [15,37] or adipocyte cultures [46]. In addition, EVs obtained from mouse serum [51], differentiated 3T3-L1 cell lines [17], and rat primary adipocyte cultures [40] were found to contain fat-cell specific proteins such as aP2 and adiponectin, suggesting that mature adipocytes can contribute to EVs in circulation.…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Adipose crosstalk with other cell types in health and disease

Choi

Cohen

2017

Experimental Cell Research

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Section: Extracellular Vesiclesmentioning

confidence: 99%

Adipose crosstalk with other cell types in health and disease

Choi

Cohen

2017

Experimental Cell Research

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“…Adipocyte-secreted exosomes are demonstrated to contain specific transcripts (such as adiponectin [123] and aP2 [124]) and miRNAs [119,99], which are transported into recipient cells and are involved in modulating gene expression as well as energy metabolism. Several studies demonstrated that adipocyte derived exosomes mediate cell-cell communication that might play a role in controlling lipogenesis and cell size [121], obesity related disease [120] and nonalcoholic fatty liver disease [125]. It is possible that exosomes from bone marrow adipose tissue under osteoporotic conditions carry different cargo to affect the osteoblastic/adipocytic fate of bone marrow MSCs.…”

Section: Excessive Adipose Tissuementioning

confidence: 99%

The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis

Liu

Zuo

et al. 2016

Aging and disease

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ABSTRACT:In the adult bone marrow, osteoblasts and adipocytes share a common precursor called mesenchymal stem cells (MSCs). The plasticity between the two lineages has been confirmed over the past decades, and has important implications in the etiology of bone diseases such as osteoporosis, which involves an imbalance between osteoblasts and adipocytes. The commitment and differentiation of bone marrow (BM) MSCs is tightly controlled by the local environment that maintains a balance between osteoblast lineage and adipocyte. However, pathological conditions linked to osteoporosis can change the BM microenvironment and shift the MSC fate to favor adipocytes over osteoblasts, and consequently decrease bone mass with marrow fat accumulation. This review discusses the changes that occur in the BM microenvironment under pathological conditions, and how these changes affect MSC fate. We suggest that manipulating local environments could have therapeutic implications to avoid bone loss in diseases like osteoporosis.

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“…In another setting, EV has been identified from supernatants of isolated adipocytes [32] or adipose stromal cells (ADSCs) [33] in culture. Adipocyte EV has been linked to lipid metabolism and obesity-related IR.…”

Section: Mirnas Involved In Cell-to-cell Communication In Metabolic Dmentioning

confidence: 99%

“…Even though several NAFLD associated miRNA have been reported, their participation in cell-to-cell communication is unknown. An interesting study reported that EV derived from obese but not from lean visceral adipose tissue can induce transforming growth factor-β (TGF-β) signaling pathway deregulation following their uptake in HepG2 cells [45]. These observations suggest the possibility of similar processes occurring in NAFLD [46].…”

Section: Mirnas Involved In Cell-to-cell Communication In Metabolic Dmentioning

confidence: 99%

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases

Matsuda

Yan

Foye

et al. 2016

Best Practice & Research Clinical Endocrinology & Metab

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The contribution of microRNAs to the regulation of mRNA expression during physiological and developmental processes are well-recognized. These roles are being expanded by recent observations that emphasize the capability of miRNA to participate in inter-cellular signaling and communication. Several factors support a functional role for miRNA as mediators of cell-to-cell signaling. miRNA are able to exist within the extracellular milieu or circulation, and their stability and integrity maintained through association with binding proteins or lipoproteins, or through encapsulation within cell-derived membrane vesicles. Furthermore, miRNA can retain functionality and regulate target gene expression following their uptake by recipient cells. In this overview, we review specific examples that will highlight the potential of miRNA to serve as paracrine signaling mediators in metabolic diseases and cancers. Elucidating the mechanisms involved in inter-cellular communication involving miRNA will provide new insights into disease pathogenesis and potential therapeutic opportunities.

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Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease

Cited by 164 publications

References 47 publications

Adipose crosstalk with other cell types in health and disease

Adipose crosstalk with other cell types in health and disease

The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis

MicroRNAs as paracrine signaling mediators in cancers and metabolic diseases

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