Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT

Kassi, Eva; Hroussalas, G.; Kazanis, K.; Merantzi, G.; Zachari, A.; Giamarellos‐Bourboulis, Evangelos J.; Dionyssiou-Asteriou, Amalia

doi:10.1016/j.maturitas.2010.05.004

Cited by 31 publications

(19 citation statements)

References 41 publications

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“…Abdominal adipose tissue deposition observed after menopause represents an important source of cytokine production, which would in turn stimulates hepatic CRP production [22][23]. In line with our study Kassi et al showed a positive correlation between BMI and hsCRP levels indicating an inflammatory status in obesity [19]. In another study it was shown that healthy postmenopausal women showed moderate increases in CRP levels within the range of 1.5-7.3 mg/L and had a graded 2-5 fold increase in the risk of future cardiovascular events [24].…”

Section: Discussionsupporting

confidence: 90%

“…Although we did not measure insulin resistance in these subjects, the increases in glucose levels may show impaired glucose metabolism in these patients. It is known that in post menopausal women lipid and lipoprotein metabolism is markedly altered [19]. In the present study, we studied lipid profiles of both pre and postmenopausal obese women.…”

Section: Discussionmentioning

confidence: 97%

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Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women

Alataş¹,

Akalın²,

Çiftçi

et al. 2014

Turk J Bioch

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Objectıve: Obesity and age related vascular changes coupled with the effect of estrogen withdrawal increases predisposition to atherosclerosis in postmenopausal women. But the functions of high density lipoprotein (HDL) were not well established in postmenopausal women. In the present study, we mainly aimed to evaluate the changes in the functions of HDL and aimed to measure, lipid peroxidation, lipid profile and homocysteine levels as a supporting evidence in pre and postmenopausal obese women as a result of estrogen depletion. Material and Methods:This study included 20 premenopausal, 22 postmenopausal 42 obese (BMI>30 kg/m2) and 26 premenopausal non-obese. These twenty six premenopausal women with normal BMI (20

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women

Alataş¹,

Akalın²,

Çiftçi

et al. 2014

Turk J Bioch

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show abstract

“…Consistent with our findings, Stringer et al 22 did not report any correlation between serum leptin and ox-LDL levels in patients with type 2 diabetes. Kassi et al 23 did not report any positive correlation between serum leptin and ox-LDL levels in postmenopausal women with impaired glucose tolerance test. Likewise Demirel et al 24 did not find any correlation between leptin and ox-LDL, when leptin was significantly correlated with very LDL, lipoprotein A, and TG in patients with poly-cystic ovary (PCO) syndrome.…”

Section: Discussionmentioning

confidence: 89%

Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients

Nakhjavani¹,

Morteza²,

Asgarani³

et al. 2011

Redox Report

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“…Low adiponectin levels are associated with abnormal glucose homeostasis, abnormal lipid metabolism, and insulin resistance in normal and in overweight or obese women [26, 27]; however, it is unclear whether low adiponectin levels mediate higher disease risk in Asians compared to Caucasians with comparable BMI [18, 21]. Because a clustering of increased metabolic, adipogenic, and proinflammatory factors are associated with lower adiponectin levels [28], complex multifactorial mechanisms of many contributing mediators may be involved rather than any single mechanism.…”

Section: Discussionmentioning

confidence: 99%

Leptin, Adiponectin, and Obesity among Caucasian and Asian Women

Conroy

Chai

Lim

et al. 2011

Mediators of Inflammation

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Ethnic differences in adipose tissue distribution may contribute to different chronic disease risks across ethnic groups, and adipokines may mediate the risk. In a cross-sectional study, we examined ethnic differences in adipokines and inflammatory markers as related to body mass index (BMI) among 183 premenopausal women with Caucasian and Asian ancestry. General linear models were used to estimate adjusted mean levels of leptin, adiponectin, interleukin-6, and C-reactive protein (CRP). Asian women had significantly lower serum levels of leptin, adiponectin, and CRP than Caucasian participants (P ≤ .01) across all levels of BMI. Among overweight and obese women, Asians showed a stronger association of CRP with leptin (β = 1.34 versus β = 0.64) and with adiponectin (β = −0.95 versus β = −0.75) than Caucasians. Compared to Caucasians of similar BMI, Asians may experience a higher chronic disease risk due to lower levels of adiponectin despite their lower levels of leptin.

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Adipocyte factors, high-sensitive C-reactive protein levels and lipoxidative stress products in overweight postmenopausal women with normal and impaired OGTT

Cited by 31 publications

References 41 publications

Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women

Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women

Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients

Leptin, Adiponectin, and Obesity among Caucasian and Asian Women

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