Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice

Wang, Shengpeng; Cao, Shuang; Arhatte, Malika; Li, Dahui; Shi, Yue; Kurz, Sabrina; Hu, Jiong; Wang, Lei; Shao, Jingchen; Atzberger, Ann; Wang, Zheng; Wang, Changhe; Zang, Wei-Jin; Fleming, Ingrid; Wettschureck, Nina; Honoré, Eric; Offermanns, Stefan

doi:10.1038/s41467-020-16026-w

Cited by 97 publications

(85 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The positive role in early adipogenesis has been described mainly in 3T3-L1 cells also for FGF2 and for FGF1 [ 26 ]. Moreover, recent studies in in vivo and ex vivo murine models indicated that FGF1 is also released by mature adipocytes to induce adipocyte precursor differentiation as a central feedback mechanism by which mature adipocytes control adipogenesis during the development of obesity [ 64 ].…”

Section: Regulation Of Adipocyte Differentiationmentioning

confidence: 99%

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

Rybińska

Mangano

Tagliabue

et al. 2021

IJMS

View full text Add to dashboard Cite

Breast cancer progression is highly dependent on the heterotypic interaction between tumor cells and stromal cells of the tumor microenvironment. Cancer-associated adipocytes (CAAs) are emerging as breast cancer cell partners favoring proliferation, invasion, and metastasis. This article discussed the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation in order to appreciate the molecular pathways that have been described to drive adipocyte dedifferentiation. Moreover, recent studies on the mechanisms through which CAAs affect the progression of breast cancer were reviewed, including adipokine regulation, metabolic reprogramming, extracellular matrix remodeling, and immune cell modulation. An in-depth understanding of the complex vicious cycle between CAAs and breast cancer cells is crucial for designing novel strategies for new therapeutic interventions.

show abstract

Section: Regulation Of Adipocyte Differentiationmentioning

confidence: 99%

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

Rybińska

Mangano

Tagliabue

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…As part of their normal function, hypertrophic adipocytes that may have reached their capacity for nutrient storage communicate signals to adipocyte progenitors to expand and differentiate, offering more sites for lipid deposition. 25,94 Two such signals, FGF1 and FGF2, classically activate FGF receptors (FGFRs). Recently, FGF1 was found to be produced by mature hypertrophic adipocytes and released through activation of the mechano-sensing ion channel Piezo1.…”

Section: Cytokines and Growth Factorsmentioning

confidence: 99%

The Tumor Promotional Role of Adipocytes in the Breast Cancer Microenvironment and Macroenvironment

Bernard

Wellberg

2021

The American Journal of Pathology

View full text Add to dashboard Cite

The role of the adipocyte in the tumor microenvironment has received significant attention as a critical mediator of the obesity-cancer relationship. Current estimates indicate that 650 million adults have obesity, and thirteen cancers, including breast cancer, are estimated to be associated with obesity. Even in people with a normal body mass index, adipocytes are key players in breast cancer progression because of the proximity of tumors to mammary adipose tissue. Outside the breast microenvironment, adipocytes influence metabolic and immune function and produce numerous signaling molecules, all of which affect breast cancer development and progression. The current epidemiologic data linking obesity, and importantly adipose tissue, to breast cancer risk and prognosis, focusing on metabolic health, weight gain, and adipose distribution as underlying drivers of obesity-associated breast cancer is presented here. Bioactive factors produced by adipocytes, both normal and cancer associated, such as cytokines, growth factors, and metabolites, and the potential mechanisms through which adipocytes influence different breast cancer subtypes are highlighted.

show abstract

“…Membrane tension was determined as previously described 58,59 . Olympus IX81 microscope (see above).…”

Section: Determination Of Cell Membrane Tensionmentioning

confidence: 99%

Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis

Offermanns

Wang

Shi

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

The extravasation of leukocytes is a critical step during inflammation which requires the localized opening of the endothelial barrier. This process is initiated by the close interaction of leukocytes with various adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) on the surface of endothelial cells. It is still unclear how these initial processes induce downstream signaling events resulting in the opening of inter-endothelial junctions to allow leukocyte diapedesis. Here we show that mechanical forces induced by leukocyte-induced clustering of ICAM-1 and fluid shear stress exerted by the flowing blood synergistically activate the mechanosensitive cation channel PIEZO1 in endothelial cells. In human and mouse endothelial cells exposed to low flow, PIEZO1 mediates leukocyte-induced increases in [Ca2+]i and activation of downstream signaling events including phosphorylation of SRC, PYK2 and myosin light chain (MLC) leading to endothelial barrier opening. Mice with endothelium-specific loss of Piezo1 show decreased leukocyte extravasation in different inflammation models. We found that actin polymerization and actomyosin contraction induced by ICAM-1 clustering synergistically with fluid shear stress increase endothelial plasma membrane tension to activate PIEZO1. Our data reveal a mechanism by which leukocytes and the hemodynamic microenvironment synergize to mechanically activate endothelial PIEZO1 and subsequent downstream signaling to initiate leukocyte diapedesis.

show abstract

Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice

Cited by 97 publications

References 60 publications

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences

The Tumor Promotional Role of Adipocytes in the Breast Cancer Microenvironment and Macroenvironment

Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis

Contact Info

Product

Resources

About