Adipocytes as Anticancer Drug Delivery Depot

Wen, Di; Wang, Jinqiang; Driessche, George Van Den; Chen, Qian; Zhang, Yuqi; Chen, Guojun; Liu, Hongjun; Soto, Jennifer; Liu, Ming; Ohashi, Masao; Wang, Zejun; Abdou, Peter; Hu, Quanyin; Dotti, Gianpietro; Li, Song; Fourches, Denis; Gu, Zhen

doi:10.1016/j.matt.2019.08.007

Cited by 66 publications

(45 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected, adipocytes carrying an anti-cancer fatty acid and a doxorubicin prodrug showed effective anti-cancer ability. Moreover, these adipocytes also down-regulated the PD-L1 expression level in tumor cells, favoring the emergence of CD4+ and CD8+ T cell-mediated immune responses [ 122 ]. Similarly, nanoparticle engineered tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-overexpressing adipose-derived stem cells could also work as drug-delivery vehicles for targeting and eradicating glioblastoma multiforme [ 123 ].…”

Section: Adipocytes and Ovarian Cancer Treatmentmentioning

confidence: 99%

Adipocytes: active facilitators in epithelial ovarian cancer progression?

Dai

Song

2020

J Ovarian Res

View full text Add to dashboard Cite

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor development. At present, the roles of adipocytes in the pathogenesis of epithelial ovarian cancer (EOC) are far from being fully elucidated. Herein, we summarized the recent advances in understanding the roles of adipocytes in EOC progression. Adipocytes, close neighbors of EOC tissue, promote EOC growth, invasion, metastasis and angiogenesis through adipokine secretion, metabolic remodeling and immune microenvironment modulation. Moreover, adipocytes are important therapeutic targets and may work as useful anticancer drug delivery depot for EOC treatment. Furthermore, adipocytes also act as a therapeutic obstacle for their involvement in EOC treatment resistance. Hence, better characterization of the adipocytes in EOC microenvironment and the crosstalk between adipocytes and EOC cells may provide insights into EOC progression and suggest novel therapeutic opportunities.

show abstract

Section: Adipocytes and Ovarian Cancer Treatmentmentioning

confidence: 99%

Adipocytes: active facilitators in epithelial ovarian cancer progression?

Dai

Song

2020

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…There are studies that are focusing on introducing adipocyte cell-based delivery platforms in cancer treatment and therapy [6,131]. At the same time, the adipocytes can be employed in other medical conditions such as regeneration and tissue engineering [132] or plastic surgery interventions [133,134].…”

Section: Adipose Cells As Delivery Platforms-isolation Loading and Cmentioning

confidence: 99%

“…The releasing rate was also increased after 100 h to almost 80%. The study combines rumenic acid anticancer effects with doxorubicin in situ synthesis [6].…”

Section: Adipose Cells' Loading Strategiesmentioning

confidence: 99%

“…Li et al [6] evaluated tumor intrinsic signaling in order to develop a mesenchymal stem cell-mediated therapy against malignant glioma. The mesenchymal stem cells derived from adipose tissue were genetically engineered using a lentiviral vector to insert a suicidal gene in response to TGF-β signaling.…”

Section: Applications Of Engineered Adipose Tissue-derived Cells In Omentioning

confidence: 99%

See 1 more Smart Citation

Adipocyte-Based Cell Therapy in Oncology: The Role of Cancer-Associated Adipocytes and Their Reinterpretation as Delivery Platforms

et al. 2020

View full text Add to dashboard Cite

Cancer-associated adipocytes have functional roles in tumor development through secreted adipocyte-derived factors and exosomes and also through metabolic symbiosis, where the malignant cells take up the lactate, fatty acids and glutamine produced by the neighboring adipocytes. Recent research has demonstrated the value of adipocytes as cell-based delivery platforms for drugs (or prodrugs), nucleic acids or loaded nanoparticles for cancer therapy. This strategy takes advantage of the biocompatibility of the delivery system, its ability to locate the tumor site and also the predisposition of cancer cells to come in functional contact with the adipocytes from the tumor microenvironment for metabolic sustenance. Also, their exosomal content can be used in the context of cancer stem cell reprogramming or as a delivery vehicle for different cargos, like non-coding nucleic acids. Moreover, the process of adipocytes isolation, processing and charging is quite straightforward, with minimal economical expenses. The present review comprehensively presents the role of adipocytes in cancer (in the context of obese and non-obese individuals), the main methods for isolation and characterization and also the current therapeutic applications of these cells as delivery platforms in the oncology sector.

show abstract

“…[3] To address these limitations, polymer-drug conjugates that link anticancer agents to a polymer through labile bonds yield macromolecular prodrugs can achieve high loading capacity, enhanced water solubility and blood circulation levels, and site-specific accumulation within tumor tissues through an enhanced permeability and retention (EPR) effect. [4] The approach for specific prodrug activation relies on the endogenous tumor-associated stimuli, for example, enzymes, antigens, and aptamer-receptors. [4a] However, these strategies might be impeded by the tumor heterogeneity and the undesired expression of tumor-associated stimuli on healthy cells.…”

mentioning

confidence: 99%