Adipocytokines and anthropometric measures in type 2 diabetics

Harke, Shubhangi; Khadke, Suresh; Ghadge, Abhijit A.; Manglekar, Ashwini S.; Shah, Shashank; Diwan, Arundhati; Kuvalekar, Aniket

doi:10.1016/j.dsx.2016.12.043

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Interestingly, this study found that leptin levels were higher in children with T1D with an increased hip circumference and lower in T1D children with a higher waist to hip ratio, indicating that leptin levels might be more dependent on non-abdominal adipose tissue. This finding is in accordance with Harke et al study on adult males with T2D, where leptin levels were negatively associated with waist to hip ratio [ 19 ].…”

Section: Discussionsupporting

confidence: 93%

“…Leptin and adiponectin are known to serve opposing roles involving the inflammatory response, which could explain the absence of the association in our study with leucocyte and neutrophil counts, observed for leptin. An inverse relationship between leptin and adiponectin has been reported in adults with T2D and in patients with obesity and coronary artery disease [ 17 , 19 ]. Leptin is a pro-inflammatory cytokine responsible for the upregulation of factors involved in the inflammatory pathway of T2D (i.e., TNF-α, IL-6) [ 6 ], while anti-inflammatory properties are attributed to adiponectin [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes

et al. 2022

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Adipokines are a superfamily of cell signaling proteins produced by the adipose tissue. This study’s purpose was to reveal the association of adipokines (leptin, adiponectin), hs-CRP, and IL-6 with well-known cardiovascular risk factors (lipid profile, diabetes control, obesity, physical activity) in children and adolescents with T1D. This cross-sectional study included 80 participants (36 boys) with T1D, aged (mean ± SD) 14.8 ± 3.4 years. Body Mass Index (BMI), metabolic profile, and level of physical activity were assessed (using pedometers) for evaluation of their effect on serum leptin, adiponectin, IL-6, and hs-CRP. Leptin levels were associated with BMI (beta = 0.184, p < 0.001), waist to hip ratio (beta = −2.017, p = 0.022), Low Density Lipoprotein-C (LDL-C) (beta = 0.021, p = 0.005), and fat mass (beta = 14.07, p < 0.001). Adiponectin was correlated with waist to height ratio (beta = 0.048, p = 0.006), ΒΜΙ (beta = −0.056, p = 0.005), and muscle mass (beta = −0.013, p = 0.020). Interestingly, hs-CRP was associated with weight (beta = 0.035, p < 0.001), ΒΜI (beta = 0.186, p < 0.001), fat mass (beta = 5.2859, p = 0.004), and muscle mass (beta = 0.027, p = 0.008). Multiple regression analysis of muscle mass unveiled associations with log hs-CRP (beta = −1.237, p = 0.014) and inverse IL−6 (beta = 18.57, p = 0.01). Finally, multiple regression models of fat mass unveiled associations with physical activity (7-day-total-step-count) (beta = −3.90 × 10−7, p = 0.027), Inverse IL-6 (beta = −0.1572, p = 0.009), and squared leptin (beta = 0.0077, p = 0.03). This study reports a positive association of leptin with LDL-C, BMI, fat mass, and hip circumference and a negative association of adiponectin with BMI and muscle mass. Finally, hs-CRP was associated with HbA1c, fat mass, and BMI. We propose that leptin, adiponectin, and hs-CRP could be used as prognostic indicators of cardiovascular risk in children with T1D.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes

et al. 2022

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“…The present study participants had more BMI and WHR and thus, our study also suggests the relationship between the anthropometric indices of adiposity and T2DM risk like the previous studies. [48][49][50][51][52][53][54][55][56][57][58][59] Daily dose of metformin in our study ranges from 500mg to 2000mg/day which is consistent with the previous study. 60 The median duration of diabetes was 4years like the previous study.…”

Section: Discussionsupporting

confidence: 89%

Efficacy and safety of Trikgudas an add-on medicine in uncontrolled type 2 diabetes mellitus (T2DM) patients with metformin monotherapy: A randomized controlled trial

Joshi¹

2022

IJCAM

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Metformin is quite effective in managing Type 2 diabetes mellitus (T2DM). Studies have reported that the combined use of oral hypoglycemic medicines is prescribed in uncontrolled T2DM metformin monotherapy. So, we aim to evaluate the efficacy and safety of Ayurvedic herbo-mineral formulation (Trikgud) in managing uncontrolled T2DM with metformin monotherapy in Nepalese population. This study was a randomized controlled trial. A total of 56 participants with the diagnosis of T2DM were randomly assigned to the intervention group (Trikgudmet) or control (Met) group in a ratio of 1:1 for 12weeks. The primary outcome measures were the difference in the change in glycated haemoglobulin (HbA1C), fasting plasma glucose (FPG) and 2-h postprandial plasma glucose (2-h PPG) between the groups, and secondary outcome measures were the change in body mass index (BMI), waist-hip ratio (WHR), lipid profile, liver function tests and renal function tests between the baseline and at 12weeks after intervention. At week 12, there were significant differences of FPG and 2-h PPG in both Trikgudmet group and Met group when compared with week 0. There was a statistically significant decrease of 8.6% and 10.1% of HbA1C levels in Trikgudmet and Met groups, respectively. This study may provide "a new evidence for use of Trikgud as an add-on therapy for uncontrolled T2DM patients with metformin monotherapy in context of Nepal.

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“…Furthermore, adiponectin are expressed lower than adipocytokines in obese people [13]. Harke et al reported that abdominal obesity in diabetic females correlates with altered levels of adipocytokines [14].…”

Section: Resultsmentioning

confidence: 99%

The relationship between waist circumference on obesity and prevalence of type 2 diabetes mellitus in male patients in the Regional Public Hospital of Tabanan Regency

Evayanti¹,

Hendra²,

Indonesiani³

2020

The Proceedings of the 1st Seminar the Emerging of Novel Corona Virus, nCov 2020, 11-12 February 2020, Bali, Indonesia

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Adipocytokines and anthropometric measures in type 2 diabetics

Cited by 6 publications

References 16 publications

The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes

The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes

Efficacy and safety of Trikgudas an add-on medicine in uncontrolled type 2 diabetes mellitus (T2DM) patients with metformin monotherapy: A randomized controlled trial

The relationship between waist circumference on obesity and prevalence of type 2 diabetes mellitus in male patients in the Regional Public Hospital of Tabanan Regency

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