Adipocytokines and ghrelin level of bipolar patients from manic episode to euthymic episode

Tunçel, Özgür Korhan; Sarısoy, Gökhan; Bilgici, Birşen; Pazvantoğlu, Ozan; Çetin, Eda; Tunçel, Ebru Kaynar

doi:10.1080/08039488.2017.1402953

Cited by 17 publications

(15 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adipokines are important modulators of fat distribution, chronic inflammation, energy expenditure and activity, appetite and satiety, adipocyte function, glucose and lipid metabolism, insulin sensitivity, and several other processes [29]. Leptin and adiponectin, which are both adipokines, have been studied in patients with BD.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and vaspin in patients with bipolar disorder

Ertekin

Şahin

Çalışkan

et al. 2018

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Metabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and vaspin in patients with bipolar disorder

Ertekin

Şahin

Çalışkan

et al. 2018

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

show abstract

“…Another opinion discriminates obesity from metabolic syndrome (MeS) in BD [7]. In this case, MeS is supposed to result from adipokines levels independently from obesity [8]. Biological explanations are also present.…”

Section: Introductionmentioning

confidence: 99%

“…But it is known that obestatin levels are decreased in obesity and seem to be negatively correlated with body mass index (BMI) [20]. Obestatin levels have not been studied in BD, but recently ghrelin which is encoded from the same gene with obestatin was found higher in euthymic period of BD than the manic episode [8].…”

Section: Introductionmentioning

confidence: 99%

Blood levels of agouti-related peptide (AgRP), obestatin, corticosteroid-binding globulin (CBG), and cortisol in patients with bipolar disorder (BD): a case–control study

Karagüzel

Kural

Ti̇ryaki̇

et al. 2018

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

OBJECTIVES: Bipolar disorder (BD) is a chronic psychiatric disorder with a high prevalence of obesity. There are a number of hypotheses regarding the association between obesity and BD. One involves common neurobiological abnormalities, such as dysfunction in the hypothalamic pituitary adrenal axis and changes in secretions of orexigenic and anorectic peptides. The purpose of this study was to evaluate the blood levels of agouti-related peptide (AgRP), obestatin cortisol, and corticosteroid-binding globulin (CBG) and metabolic parameters in patients with euthymic BD, and to compare these to those of healthy controls. METHODS: Twenty-nine outpatients with BD type I admitted to the psychiatric clinic were consecutively enrolled and compared with 25 sex-and body mass index (BMI)-matched controls. RESULTS: There was a significant difference in AgRP, cortisol, and CBG levels between patients and the controls (p = .005, .021, and .034, respectively). AgRP and CBG did not correlate with any parameter in BD patients, but cortisol correlated with BMI. CONCLUSIONS: We conclude that BD patients have higher levels of AgRP, cortisol, and CBG than healthy controls with similar BMIs. This may represent a new insight into the neurobiology of BD.

show abstract

“…Metabolic syndrome (MetS) is a well-documented in MDD patients, with the risk of MetS in depressed patient at 1.5 times higher than in the non-depressed population ( 19 ). Moreover, the prevalence of MetS is 58% higher in psychiatric patients than in the general population ( 20 ), with prominent anorexigenic and orexigenic hormones leptin and ghrelin identified to be associated with psychiatric disorders including schizophrenia, bipolar disorder and major depression ( 21 – 23 ). A role for the microbiome in metabolic syndrome has received attention, with studies demonstrating a role for gut microbiota in features of MetS, such as obesity, diabetes, dyslipidemia and hypertension ( 24 , 25 ).…”

mentioning

confidence: 99%

Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder

Horne

Foster

2018

Front. Psychiatry

View full text Add to dashboard Cite

Advances in understanding the role of the microbiome in physical and mental health are at the forefront of medical research and hold potential to have a direct impact on precision medicine approaches. In the past 7 years, we have studied the role of microbiota-brain communication on behavior in mouse models using germ-free mice, mice exposed to antibiotics, and healthy specific pathogen free mice. Through our work and that of others, we have seen an amazing increase in our knowledge of how bacteria signal to the brain and the implications this has for psychiatry. Gut microbiota composition and function are influenced both by genetics, age, sex, diet, life experiences, and many other factors of psychiatric and bodily disorders and thus may act as potential biomarkers of the gut-brain axis that could be used in psychiatry and co-morbid conditions. There is a particular need in major depressive disorder and other mental illness to identify biomarkers that can stratify patients into more homogeneous groups to provide better treatment and for development of new therapeutic approaches. Peripheral outcome measures of host-microbe bidirectional communication have significant translational value as biomarkers. Enabling stratification of clinical populations, based on individual biological differences, to predict treatment response to pharmacological and non-pharmacological interventions. Here we consider the links between co-morbid metabolic syndrome and depression, focusing on biomarkers including leptin and ghrelin in combination with assessing gut microbiota composition, as a potential tool to help identify individual differences in depressed population.

show abstract

Adipocytokines and ghrelin level of bipolar patients from manic episode to euthymic episode

Abstract: The present results point that high leptin, resistin and ghrelin levels may be involved in the early pathophysiological process which can lead to later obesity and MeS in patients with bipolar disorder.

Cited by 17 publications

References 48 publications

Metabolic syndrome and vaspin in patients with bipolar disorder

Metabolic syndrome and vaspin in patients with bipolar disorder

Blood levels of agouti-related peptide (AgRP), obestatin, corticosteroid-binding globulin (CBG), and cortisol in patients with bipolar disorder (BD): a case–control study

Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder

Contact Info

Product

Resources

About