Adipocytokines: Emerging therapeutic targets for pain management

Gao, Shao-Jie; Liu, Dai-Qiang; Li, Danyang; Sun, Jia; Zhang, Long-Qing; Wu, Jiayi; Song, Fan‐He; Zhou, Ya‐Qun; Mei, Wei

doi:10.1016/j.biopha.2022.112813

Cited by 4 publications

(1 citation statement)

References 104 publications

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“…The body’s adipose tissue plays an important role in its functioning by performing endocrine, metabolic and immunoregulatory functions [ 44 ]. It has been shown to produce approximately 600 different pro- and anti-inflammatory signaling mediators, including leptin, resistin, adiponectin, visfatin and apelin—referred to as adipocytokines [ 44 , 45 , 46 , 47 , 48 ]. Adipocytokines are biologically active molecules that are mainly produced by adipocytes.…”

Section: Adipocytokinesmentioning

confidence: 99%

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

Stępień

Olczyk

Gola

et al. 2023

Cells

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Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology—ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.

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