Adipocytokines in Cardiovascular and Metabolic Diseases

Ouchi, Noriyuki

doi:10.5551/jat.34918

Cited by 34 publications

(39 citation statements)

References 85 publications

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“…An interviewer inquired about change in body weight of 3 kg or more within the previous year, exercise habits (1, to continue 30 minutes of exercise twice a week or more for more than one year; 2, walking for one hour a day or equivalent physical activity), sleeping quality, cigarette smoking status, and weekly alcohol intake (current at ≥ 44 g/day, current at < 44 g/day, never, or former). Participants that consumed ≥ 44 g ethanol or more per day were classified as being current excessive drinkers because previous study reported that increase in risk of all causes mortality or coronary risk was observed among current excessive drinkers 8, 9) .…”

Section: Methodsmentioning

confidence: 99%

“…Evacuees may therefore be more susceptible than non-evacuees to cardiovascular risk factors, such as visceral obesity, hypertension, diabetes mellitus, and dyslipidemia 7) and metabolic syndrome, which is cluster of these risk factors and has been reported to be associated with low level of plasma adiponectin and higher risk of incidence of cardiovascular diseases 8, 9) . However, few reports have been published concerning the influence of post-disaster evacuation on metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome

Hashimoto

Nagai

Fukuma

et al. 2017

J Atheroscler Thromb

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Aim: After the Great East Japan Earthquake, over 160,000 residents near the Fukushima Daiichi Nuclear Power Plant were forced to evacuate due to a nuclear accident. Health problems in these evacuees have since become major issues. We examined the association between evacuation and incidence of metabolic syndrome (METS) among residents in Fukushima.Methods: We conducted a cohort study among residents aged 40–74 years without METS at the time of the disaster in Fukushima. Among 20,269 residents who met the inclusion criteria before the disaster, 8,547 residents (3,697 men and 4,850 women; follow-up proportion: 42.2%) remained available for follow-up examinations after the disaster by the end of March 2013. The main outcome was incidence of METS, defined by guidelines from the Japanese committee, using data from the Comprehensive Health Check before and after the disaster. We divided participants by evacuation status and compared outcomes between groups. Using a logistic regression model, we estimated the odds ratio for incidence of METS, adjusting for potential confounders, age, gender, waist circumference, exercise habit, and alcohol consumption.Results: Incidence of METS was higher in evacuees (men 19.2%, women 6.6%) than in non-evacuees (men 11.0%, women 4.6%). Evacuees had higher body mass index, waist circumference, triglycerides, and fasting plasma glucose after the disaster than non-evacuees. We found a significant association between evacuation and incidence of METS (adjusted odds ratio 1.72, 95% confidence interval; 1.46–2.02).Conclusion: This is the first study to demonstrate that evacuation after a disaster is associated with increased incidence of METS.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome

Hashimoto

Nagai

Fukuma

et al. 2017

J Atheroscler Thromb

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“…MetS in the context of obesity is associated with the development of a chronic subclinical systemic inflammatory state [3]. Major players in the development of this inflammatory milieu are adipocytokines, adipokines, and cytokines produced by white adipocytes that closely regulate lipid metabolism and the inflammatory response [4], and contribute to the development of insulin resistance [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

Effects of bariatric surgery on telomere length and T-cell aging

et al. 2019

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Background Obesity adversely affects health and is associated with subclinical systemic inflammation and features of accelerated aging, including the T-cell immune system. The presence of metabolic syndrome (MetS) may accelerate, while bariatric surgery might reverse these phenomena. To examine the effects of MetS and bariatric surgery on T-cell aging, we measured relative telomere length (RTL) and T-cell differentiation status in obese patients before and after bariatric surgery. Methods WHO II/III classified obese patients scheduled for bariatric surgery were included: 41 without MetS and 67 with MetS. RTL and T-cell differentiation status were measured in circulating CD4 + and CD8 + T cells via flow cytometry. T-cell characteristics were compared between patients with and without MetS prior to and at 3, 6, and 12 months after surgery considering effects of age, cytomegalovirus-serostatus, and weight loss. Results Thymic output, represented by numbers of CD31-expressing naive T cells, showed an age-related decline in patients with MetS. MetS significantly enhanced CD8 + T-cell differentiation. Patients with MetS had significant lower CD4 + RTL than patients without MetS. Within the first 6 months after bariatric surgery, RTL increased in CD4 + T cells after which it decreased at month 12. A decline in both thymic output and more differentiated T cells was seen following bariatric surgery, more pronounced in the MetS group and showing an association with percentage of body weight loss. Conclusions In obese patients, MetS results in attrition of RTL and accelerated T-cell differentiation. Bariatric surgery temporarily reverses these effects. These data suggest that MetS is a risk factor for accelerated aging of T cells and that MetS should be a more prominent factor in the decision making for eligibility for bariatric surgery.

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“…Lifestyle interventions focused on weight loss are often intensive, expensive, and temporary, with most people regaining weight within two to four years (Anderson, Gutierrez, Kennedy, & Hasty, 2013;Gaesser, Angadi, Sawyer, Tucker, & Jarrett, 2014;Montani, Schutz, & Dulloo, 2015). Furthermore, regained weight is often met with repeated bouts of dieting, or weight cycling, which may be more harmful metabolically than simply being overweight, (Montani et al, 2015) as the regained weight is more likely to be visceral (truncal) fat (Al Hannan & Culligan, 2015;Ouchi, 2016). Visceral fat is especially unhealthy and linked to insulin resistance and inflammation, both precursors of cardiometabolic disease (Al Hannan & Culligan, 2015;Park, Kwak, Kim, & Ahima, 2017)).…”

Section: Introductionmentioning

confidence: 99%

Training Dieters to Eat Intuitively with a Mobile Application

Outland

2018

CALIF J HEALTH PROMOT

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Weight loss is commonly recommended to prevent cardiometabolic diseases like hypertension, heart disease, and diabetes. Rather than lead to a long-term healthy weight, dieting can result in weight cycling, which has been shown to be more harmful to health than being overweight. An emerging solution to prevent both excess weight gain and weight cycling is to avoid extremes of hunger and fullness by eating intuitively. Intuitive eating or mindful eating means tuning into interoceptive cues of hunger and fullness to guide when and how much to eat. Mindful eating has been linked to both heart, and metabolic health. It is, however, often labor intensive to retrain chronic dieters to intuitively eat what they need, and nothing more. This study describes a mobile health application that mimics an in-office intuitive eating coaching session. It utilizes homeostasis concepts, and components of the Health Belief Model; including, cues to action, phone prompts, minimal barriers to use, and self-efficacy through repeated immediate feedback. It is expected that this innovation could assist or replace the more labor-intensive in-person methods that exist to train previous dieters to eat intuitively. An enhanced description of this mobile application, the PaleoIntuitive app, is presented in this paper along with a discussion of its expected impact on health behavior.

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Adipocytokines in Cardiovascular and Metabolic Diseases

Cited by 34 publications

References 85 publications

Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome

Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome

Effects of bariatric surgery on telomere length and T-cell aging

Training Dieters to Eat Intuitively with a Mobile Application

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