Adipocytokines modulate ionic currents – A key to lipotoxicity potentiated cardiac arrhythmia

Arrhythmia Risk and Obesity

“…Higher adiponectin levels were detected in patients with chronic atrial fibrillation than in paroxysmal atrial fibrillation, correlated with a collagen type I degradation marker, demonstrating that adiponectin is a useful marker of atrial remodeling [65]. Activation of fibroblasts and subsequent fibrosis contribute to atrial structural remodeling and heterogeneity of the cardiac conduction tissue [56,60,65].…”

“…Several biomarkers have been identified as a link between obesity and atrial fibrillation, including inflammatory markers, adipocytokines, pericardial and epicardial fat, and atrial tissue [27,57,58]. Obesity is an established inflammatory condition [59], and adipocytes enable local inflammation through adipocytokines and proinflammatory cytokines [60]. Inflammation, measured by plasma levels of high sensitivity C reactive protein, fibrinogen and soluble intracellular adhesion molecule-1, was significantly associated with the risk of incident atrial fibrillation in healthy, middle-aged women, free of cardiovascular disease [58].…”

“…Adiponectin is one of the adipocytokines secreted by the adipose tissue, both a biomarker and a possibly mediator of cardiovascular disease, with antiatherogenic, antidiabetic and antiinflammatory properties, able to influence the extent of atrial and left ventricular remodeling, which can increase cardiac contractility and action potential duration by inhibiting delayed rectifier potassium currents [59,60,65]. Higher adiponectin levels were detected in patients with chronic atrial fibrillation than in paroxysmal atrial fibrillation, correlated with a collagen type I degradation marker, demonstrating that adiponectin is a useful marker of atrial remodeling [65].…”