Adipogenesis Regulation and Endocrine Disruptors: Emerging Insights in Obesity

González-Casanova, Jorge Enrique; Pertuz-Cruz, Sonia Liliana; Caicedo-Ortega, Nelson Hernando; Rojas-Gómez, Diana Marcela

doi:10.1155/2020/7453786

Cited by 45 publications

(49 citation statements)

References 85 publications

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“…A study of adults in NHANES showed that higher levels of metals in blood or urine were associated with higher body mass index (BMI) 28 . A review by González-Casanova et al suggests that the possible pathological pathway to this link is similar to the mechanism of endocrine disrupting chemicals 29 . Hematology-related outcomes, neurological, respiratory and psychiatric morbidities appeared to be associated with more than one dominant metal, which possibly has to do with their multi-factorial nature.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to metals and morbidity at eight years follow-up in women of childbearing age

Karakis

Baumfeld

Landau

et al. 2021

Sci Rep

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This exploratory study was aimed to investigate the link between toxic metal content in women’s urine and their morbidity 2 years before and 6 years after the test. Concentrations of 25 metals in urine were analyzed for 111 pregnant women collected prior to delivery. All women were of Arab-Bedouin origin. Information on primary care and hospital visits during the study period was obtained. In a Poisson regression model, a health outcome was regressed over metal exposure and other factors. A Weighted Quantile Sum Regression (WQS) approach was used to indicate metals dominating in their possible impact on women's morbidity. Obesity was the most frequently diagnosed condition in this population (27.9%). Diagnoses in a neurological category accounted for 36.0%, asthma or respiratory—25.2%, psychiatric—12.6%, cardiovascular—14.4% and cancer or benign growth—for 13.5%. Based on WQS analysis, cancer and benign growth were mostly attributed to the increased levels of cadmium, cardiovascular outcomes were linked with lead, and obesity was found associated with elevated levels of nickel. Hematological, neurological and respiratory outcomes were attributed to multiple non-essential metals. The health and exposure profile of women in the study warrants a periodic biomonitoring in attempt to identify and reduce exposure to potentially dangerous elements.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure to metals and morbidity at eight years follow-up in women of childbearing age

Karakis

Baumfeld

Landau

et al. 2021

Sci Rep

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“…Adipocytes are functionally classified as endocrine-active and are sensitive to changes induced by endocrine disruptors, which have been termed “obesogens” [ 64 ]. These substances may trigger an increase in adiposity by altering the cellular development program in adipocytes, increasing triglyceride storage and interfering with the neuroendocrine control of hunger and satiety centers [ 65 , 66 ]. Some of the chemicals we typically encountered tend to cause changes in fat cell metabolism.…”

Section: Environment and Obesitymentioning

confidence: 99%

Control of Adipose Cell Browning and Its Therapeutic Potential

Lizcano

Arroyave

2020

Metabolites

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Adipose tissue is the largest endocrine organ in humans and has an important influence on many physiological processes throughout life. An increasing number of studies have described the different phenotypic characteristics of fat cells in adults. Perhaps one of the most important properties of fat cells is their ability to adapt to different environmental and nutritional conditions. Hypothalamic neural circuits receive peripheral signals from temperature, physical activity or nutrients and stimulate the metabolism of white fat cells. During this process, changes in lipid inclusion occur, and the number of mitochondria increases, giving these cells functional properties similar to those of brown fat cells. Recently, beige fat cells have been studied for their potential role in the regulation of obesity and insulin resistance. In this context, it is important to understand the embryonic origin of beige adipocytes, the response of adipocyte to environmental changes or modifications within the body and their ability to transdifferentiate to elucidate the roles of these cells for their potential use in therapeutic strategies for obesity and metabolic diseases. In this review, we discuss the origins of the different fat cells and the possible therapeutic properties of beige fat cells.

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“…As described, many EDs have been established as MDCs and, as such, have adverse effects on metabolic health [15][16][17][18][19][20][21]. Suspected MDCs from compound classes that have been shown to interact with metabolism-related NRs, have effects on mitochondrial function, or cause adverse metabolic effects, e.g., by inhibiting key enzyme of glucose utilization, are prime candidates for EDCMET studies (Table 1).…”

Section: Edcmet Approachmentioning

confidence: 99%

“…Indeed, epidemiological data from humans and experimental data from rodents indicate that exposure to certain EDs, the so-called metabolism disrupting chemicals (MDCs), may predispose patients to different components of metabolic syndrome, T2D, and NAFLD (for reviews, see [15][16][17][18][19][20]). The main targets for MDCs are liver and adipose tissue, where they can provoke, e.g., adipogenesis and fat accumulation [21], insulin resistance [22], and changes in cholesterol and bile acid metabolism [18][19][20]. MDCs have also been shown to regulate nutrient ingestion and metabolism by altering the composition of gut microbiota and intestinal transport.…”

Section: Introductionmentioning

confidence: 99%

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

Küblbeck

Vuorio

Niskanen

et al. 2020

IJMS

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Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm.

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Adipogenesis Regulation and Endocrine Disruptors: Emerging Insights in Obesity

Cited by 45 publications

References 85 publications

Exposure to metals and morbidity at eight years follow-up in women of childbearing age

Exposure to metals and morbidity at eight years follow-up in women of childbearing age

Control of Adipose Cell Browning and Its Therapeutic Potential

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

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