Adipogénesis y osteoporosis

Rodríguez, Juan ́Pablo; Astudillo, Pablo; Rı́os, Susana; Seitz, Germán; Pino, Ana María

doi:10.4067/s0034-98872009000600015

Cited by 12 publications

(13 citation statements)

References 76 publications

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“…It is postulated therefore that a contributory factor in osteoporosis is a diversion of activated mesenchymal stem cells from osteogenesis into adipocytogenesis [16,17].…”

Section: Discussionmentioning

confidence: 99%

“…Adipocytes are the stromal components of bone marrow and in several instances their numbers increase in bone pathology [15][16][17]. Adipocytes and osteoblasts share a common precursor cell in the bone marrow stroma, termed the mesenchymal stem cell [16,[20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Adipocytes and osteoblasts share a common precursor cell in the bone marrow stroma, termed the mesenchymal stem cell [16,[20][21][22][23]. A switch of differentiation of stromal stem cells from an osteogenic lineage into adipocytogenesis impairs bone formation by reducing the number of bone forming cells [22].…”

Section: Discussionmentioning

confidence: 99%

“…There is an inverse correlation between bone loss and increment of marrow adipocyte content [15,16]. Also it has been shown that suppression of adipogenesis within bone marrow promotes bone formation [17].…”

Section: Introductionmentioning

confidence: 99%

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The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts

Włodarski¹,

Galus²,

Brodzikowska³

et al. 2012

Folia Histochem Cytobiol.

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Abstract:The relative proportion of adipocytes to hematopoietic elements in the marrow of heterotopically induced bone evaluated 4-42 weeks post implantation of demineralized murine incisors was estimated by histological analysis of hematoxylin-eosin stained tissue sections. Using computerized image analysis of microphotographs, the proportion of nuclear cells vs. adipocytes was ascertained. The percentage of adipocytes in marrow increases over time. Such an effect, the replacement of myelopoietic marrow by adipogenic (yellow) marrow and the resorption of induced bone, is observed in human osteoporosis. A decline in the non-adipogenic cell compartments of bone marrow accompanying induced bone begins in the fourth week of induction, gradually progresses until the 26 th week, and does not change after that. The luminosity, a parameter used in image analysis and proportional to the number of nuclear cells, was 124 ± 3 in hematopoietic femoral bone marrow, and that of bone marrow of the induced bone was of a similar value (117 ± 8) in the fourth week. An evident decline in luminosity of bone marrow filling the foci of heterotopic bone was observed in samples taken at nine weeks (82 ± 20). This process progressed until the 26 th week, reaching a luminosity of 70 ± 21. At the 42 nd week, the luminosity remained at the same level (71 ± 27). This indicates that the replacement of hematopoietic bone marrow of heterotopically induced bone by unilocular adipocytes begins relatively early (the fourth week) and is persistent.

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“…It is postulated therefore that a contributory factor in osteoporosis is a diversion of activated mesenchymal stem cells from osteogenesis into adipocytogenesis [16,17].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts

Włodarski¹,

Galus²,

Brodzikowska³

et al. 2012

Folia Histochem Cytobiol.

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“…The decline in estrogen levels associated with menopause causes bone loss in women. Estrogen deficiency increases differentiation in bone marrow adipose tissue (12) and attenuates the proliferation and differentiation of osteoprogenitors (13). Sex steroid hormones act on their target cells by binding to members of the nuclear hormone receptor superfamily: estrogens bind to estrogen receptor (ER) α or ERβ.…”

Section: Introductionmentioning

confidence: 99%

17-β-estradiol up-regulates apolipoprotein genes expression during osteoblast differentiation <i>in vitro </i>

Gui

Chu

Tang

et al. 2016

BST

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Treadmill training prevents bone loss by inhibition of PPARγ expression but not promoting of Runx2 expression in ovariectomized rats

Chen

Wang

et al. 2011

Eur J Appl Physiol

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Exercise training has been reported to prevent bone loss in ovariectomized (OVX) rats and postmenopausal women. We hypothesized that treadmill training inhibited adipogenesis and enhanced osteogenesis through the regulation of adipocyte differentiation factor peroxisome proliferators-activated receptor gamma (PPARγ) and the osteogenic factor runt-related transcription factor 2 (Runx2) in a model of OVX-induced osteoporosis. To test this hypothesis, 3-month-old female Sprague-Dawley rats were divided randomly into the following groups: Sham, OVX, OVX exercised (EX), and OVX estrogen replacement (E(2)). At the end of the experiment, the bone mineral density (BMD) was detected using DEXA and the morphology change of bone tissues and uterus was observed by HE staining. The protein expression for PPARγ and Runx2 were measured by immunohistochemistry and western blot and the bone triacylglycerol (TG) was extracted by methanol/chloroform. OVX dramatically increased the number of fat vacuoles, protein levels for PPARγ and Runx2 as well as the TG level in tibiae and lumbar vertebrate. In contrast, the serum level of E(2), the lumbar vertebrate BMD as well as the proximal and distal femur BMD was significantly decreased in the OVX group. All changes induced by OVX were significantly reversed by exercise treatment except for the protein expression level of Runx2. Moreover, exercise treatment produced no estrogenic effects on uterus as evidenced by the uterus wet weight and histology. Treadmill training could prevent bone loss induced by OVX through the inhibition of adipocyte differentiation factor PPARγ rather than promoting osteogenic factor Runx2.

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Adipogénesis y osteoporosis

Cited by 12 publications

References 76 publications

The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts

The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts

17-β-estradiol up-regulates apolipoprotein genes expression during osteoblast differentiation <i>in vitro </i>

Treadmill training prevents bone loss by inhibition of PPARγ expression but not promoting of Runx2 expression in ovariectomized rats

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