Adipokine Levels in the Course of Mild Biliary Pancreatitis

Abstract

Objectives: Obesity markedly increases the risk of severe acute pancreatitis (AP). Several adipokines have been ascribed a role as a predictor of clinical severity in AP. Therefore, the aim of this study was to investigate a possible relationship between leptin and adiponectin and mild biliary AP. Methods: We included 24 consecutive patients with mild biliary AP and 24 consecutive healthy age- and sex-matched controls. Clinical severity was classified by the Ranson score. ELISA was used to assess leptin and adiponectin levels on admission and in remission. Complete blood cell counts and other laboratory tests were also performed at baseline and in remission. Results: Leptin, adiponectin, insulin and HOMA-IR measurements showed no difference in pancreatitis patients both on admission and in remission compared to the control group. No difference was found in leptin, insulin or HOMA-IR levels in the course of pancreatitis. However, adiponectin levels were higher in remission compared to admission. Conclusions: Increased adiponectin levels in remission may be an indication of improvement in this condition. Further studies are needed to determine whether adiponectin provides protection from AP.

Comparing the preventive effect of sodium hydrosulfide, leptin, and curcumin against L-arginine induced acute pancreatitis in rats: role of corticosterone and inducible nitric oxide synthase

“…This was accompanied with improvement of pancreatic histopathological changes which is in agreement with the data of Ghantous et al (2015). This can be explained by inhibition of pancreatic exocrine secretion through direct effect on pancreatic acini with subsequent reduction of intrapancreatic enzyme activity and attenuation of pancreatic damage in the course of AP, increase in the anti-inflammatory mediators with decrease in the release of pro-inflammatory cytokines, glucocorticoids release, decrease in inducible NO and increase in antioxidant level (Demirci et al 2012;Zhou et al 2016).…”

The effect of enteral nutrition on adipokines in patients with acute pancreatitis

“…Hence, it is conceivable that EN exerts its effect via a mechanism other than improvement in gut barrier function, at least in some patients. A possible alternative mechanism for the therapeutic benefit of EN is through adipokines – adipose tissue-derived cytokines ( 19 , 20 ) . A recent clinical study of sixteen patients with Crohn's disease found that patients who received exclusive EN for 4 weeks prior to ileal resection had lower leptin concentrations and higher adiponectin concentrations compared with those who received no specific nutrition therapy ( 21 ) .…”